Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury.

abstract：:Serum deprivation or withdrawal induces apoptosis in endothelial cells, resulting in endothelial cell dysfunction that is associated with cardiovascular disease. However, there is still limited information on the role of miRNA in serum deprivation-induced apoptosis. Here we found that serum deprivation increased caspa...

journal_title：Cell death & disease

authors： Kim JH,Lee DK,Kim J,Choi S,Park W,Ha KS,Kim TH,Choe J,Won MH,Kwon YG,Kim YM

更新日期：2017-05-18 00:00:00

abstract：:Cancer cells have developed chemoresistance and have improved their survival through the upregulation of autophagic mechanisms that protect mitochondrial function. Here, we report that the traditional Chinese anticancer agent tubeimoside I (Tub), which is a potent inhibitor of autophagy, can promote mitochondria-assoc...

journal_title：Cell death & disease

authors： Wang K,Zhan Y,Chen B,Lu Y,Yin T,Zhou S,Zhang W,Liu X,Du B,Wei X,Xiao J

更新日期：2020-08-26 00:00:00

abstract：:Extremely reduced oxygen (O2) levels are detrimental to myogenic differentiation and multinucleated myotube formation, and chronic exposure to high-altitude hypoxia has been reported to be an important factor in skeletal muscle atrophy. However, how chronic hypoxia causes muscle dysfunction remains unknown. In the pre...

journal_title：Cell death & disease

authors： Zhang Z,Zhang L,Zhou Y,Li L,Zhao J,Qin W,Jin Z,Liu W

更新日期：2019-07-18 00:00:00

abstract：:The aim of the present report was to investigate whether, in the mammalian spinal cord, cell death induced by transient excitotoxic stress could trigger activation and proliferation of endogenous neuroprogenitor cells as a potential source of a lesion repair process and the underlying time course. Because it is diffic...

journal_title：Cell death & disease

authors： Mazzone GL,Mladinic M,Nistri A

更新日期：2013-10-31 00:00:00

abstract：:Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...

journal_title：Cell death & disease

authors： Wassermann-Dozorets R,Rubinstein M

更新日期：2017-04-06 00:00:00

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function and ROS level in thymocytes and neurons. In this study, we repor...

journal_title：Cell death & disease

authors： Chen Y,Li L,Ni W,Zhang Y,Sun S,Miao D,Chai R,Li H

更新日期：2015-01-22 00:00:00

abstract：:Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has a fundamental role in cancer growth and metastasis. Even though PPP blockade has been pointed out as a very promising strategy against cancer, effective anti-PPP agents are not still available in the clinical setting. Here we demonstrate ...

journal_title：Cell death & disease

authors： Mele L,Paino F,Papaccio F,Regad T,Boocock D,Stiuso P,Lombardi A,Liccardo D,Aquino G,Barbieri A,Arra C,Coveney C,La Noce M,Papaccio G,Caraglia M,Tirino V,Desiderio V

更新日期：2018-05-01 00:00:00

abstract：:We have recently found that primary rat embryonic fibroblasts (REFs) could be immortalized by overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2). A derived cell line, designated 18IM, expressed the embryonic stem cell markers SSEA-1 and Sox2. Upon inoculation into severe combined immunodefici...

journal_title：Cell death & disease

authors： Yenamandra SP,Darekar SD,Kashuba V,Matskova L,Klein G,Kashuba E

更新日期：2012-01-19 00:00:00

abstract：:We previously reported that marchantin M (Mar) is an active agent to induce apoptosis in human prostate cancer (PCa), but the molecular mechanisms of action remain largely unknown. Here, we demonstrate that Mar potently inhibited chymotrypsin-like and peptidyl-glutamyl peptide-hydrolyzing activities of 20S proteasome ...

journal_title：Cell death & disease

authors： Jiang H,Sun J,Xu Q,Liu Y,Wei J,Young CY,Yuan H,Lou H

更新日期：2013-08-08 00:00:00

abstract：:Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1α and HIF-2α, emerging evidence suggests differences between both molecules in terms of transcriptiona...

journal_title：Cell death & disease

authors： Zhao J,Du F,Shen G,Zheng F,Xu B

更新日期：2015-01-15 00:00:00

abstract：:We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone...

journal_title：Cell death & disease

authors： Li D,Wang WJ,Wang YZ,Wang YB,Li YL

更新日期：2019-10-03 00:00:00

abstract：:This corrects the article DOI: 10.1038/cddis.2017.172. ...

journal_title：Cell death & disease

authors： Rodrigues PM,Afonso MB,Simão AL,Carvalho CC,Trindade A,Duarte A,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM,Castro RE

更新日期：2017-05-25 00:00:00

abstract：:Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...

journal_title：Cell death & disease

authors： Chen G,Shi Y,Liu M,Sun J

更新日期：2018-02-07 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest and apoptosis in hum...

journal_title：Cell death & disease

authors： Liao YJ,Bai HY,Li ZH,Zou J,Chen JW,Zheng F,Zhang JX,Mai SJ,Zeng MS,Sun HD,Pu JX,Xie D

更新日期：2014-03-20 00:00:00

abstract：:Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been e...

journal_title：Cell death & disease

authors： Wu C,Li Z,Ding X,Guo X,Sun Y,Wang X,Hu Y,Li T,La X,Li J,Li JA,Li W,Xue L

更新日期：2019-11-26 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:The biological clock is an endogenous biological timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled in livers. However, how the clock genes respond to toxins and influence toxicity keeps unclear. We identified t...

journal_title：Cell death & disease

authors： Ge W,Wang T,Zhao Y,Yang Y,Sun Q,Yang X,Gao Y,Xu X,Zhang J

更新日期：2021-01-12 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...

journal_title：Cell death & disease

authors： Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

更新日期：2017-01-05 00:00:00

abstract：:Mast cells are prominent components of solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, their precise mechanism of communication in gastric cancer remains largely unclear. Here, we found that patients with GC showed a significantly higher mast cell infiltration in tumors. Mas...

journal_title：Cell death & disease

authors： Lv YP,Peng LS,Wang QH,Chen N,Teng YS,Wang TT,Mao FY,Zhang JY,Cheng P,Liu YG,Kong H,Wu XL,Hao CJ,Chen W,Zhu J,Han B,Ma Q,Li K,Zou Q,Zhuang Y

更新日期：2018-10-10 00:00:00

abstract：:Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty acid (n-3 PUFA), which is largely contained in fish or fish oil, has been reported to promote cell viab...

journal_title：Cell death & disease

authors： Gao B,Han YH,Wang L,Lin YJ,Sun Z,Lu WG,Hu YQ,Li JQ,Lin XS,Liu BH,Jie Q,Yang L,Luo ZJ

更新日期：2016-05-26 00:00:00

abstract：:Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer (CRC) patients. The role of the differentially expressed lncRNAs in 5-Fluorouracil chemoresistance has not fully explained. Here, we observed lncRNA H19 was associated with the 5-Fu resistance in CRC. Quantitative analysis in...

journal_title：Cell death & disease

authors： Wang M,Han D,Yuan Z,Hu H,Zhao Z,Yang R,Jin Y,Zou C,Chen Y,Wang G,Gao X,Wang X

更新日期：2018-11-19 00:00:00

abstract：:Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that have the potency of inhibiting collagen synthesis and thus attenuating organ fibrosis. In this study, we found that flavones with 5, 7, 3', 4' hydroxy substituti...

journal_title：Cell death & disease

authors： Zhang Y,Wang J,Zhou S,Xie Z,Wang C,Gao Y,Zhou J,Zhang X,Li Q

更新日期：2019-02-11 00:00:00

abstract：:Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial membrane potential an...

journal_title：Cell death & disease

authors： Mollinedo F,Fernández M,Hornillos V,Delgado J,Amat-Guerri F,Acuña AU,Nieto-Miguel T,Villa-Pulgarín JA,González-García C,Ceña V,Gajate C

更新日期：2011-05-19 00:00:00

abstract：:Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure...

journal_title：Cell death & disease

authors： Wang L,Gundelach JH,Bram RJ

更新日期：2017-05-18 00:00:00

abstract：:Dihydroartemisinin (DHA) and its analogs are reported to possess selective anticancer activity. Here, we reported a novel DHA derivative DHA-37 that exhibited more potent anticancer activity on the cells tested. Distinct from DHA-induced apoptosis, DHA-37 triggered excessive autophagic cell death, and became the main ...

journal_title：Cell death & disease

authors： Liu X,Wu J,Fan M,Shen C,Dai W,Bao Y,Liu JH,Yu BY

更新日期：2018-10-15 00:00:00

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's diseas...

journal_title：Cell death & disease

authors： Gradzka S,Thomas OS,Kretz O,Haimovici A,Vasilikos L,Wong WW,Häcker G,Gentle IE

更新日期：2018-05-01 00:00:00