Abstract:
:We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone, or in combination, on cellular apoptosis and proliferation were analyzed and it was confirmed that LBP promotes 125I-induced apoptosis and inhibition of proliferation of HCC. Furthermore, isobaric tag for relative and absolute quantification labeling analyses suggested that 125I promoted the apoptosis and inhibition of proliferation of HCC cells by upregulating the expression of PERK-eIF2α-ATF4-CHOP pathway, a well-known apoptosis-related pathway. Moreover, LBP was found to boost the 125I-induced upregulation of this pathway and increase the apoptosis. Our data indicate that LBP promotes the apoptotic and anti-proliferative effects of 125I and provide a firm foundation for better clinical application of this combination therapy.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Li D,Wang WJ,Wang YZ,Wang YB,Li YLdoi
10.1038/s41419-019-1918-1subject
Has Abstractpub_date
2019-10-03 00:00:00pages
744issue
10issn
2041-4889pii
10.1038/s41419-019-1918-1journal_volume
10pub_type
杂志文章abstract::Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...
journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 已发布勘误
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journal_title:Cell death & disease
pub_type: 杂志文章,评审
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.20
更新日期:2013-02-21 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2016.408
更新日期:2016-12-08 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2013-05-23 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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更新日期:2014-02-13 00:00:00
abstract::Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...
journal_title:Cell death & disease
pub_type: 杂志文章
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abstract::Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
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更新日期:2017-09-07 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章,评审
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更新日期:2014-02-20 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2010-11-04 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2020-03-30 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2019-01-10 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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