Abstract:
:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy and cancer continue to remain an enigma. Why does autophagy have either pro-survival (oncogenic) or pro-death (tumor suppressive) role at different cancer stages, including cancer stem cell, initiation and progression, invasion and metastasis, as well as dormancy? How does autophagy modulate a series of oncogenic and/or tumor suppressive pathways, implicated in microRNA (miRNA) involvement? Whether would targeting the oncogenic and tumor suppressive autophagic network be a novel strategy for drug discovery? To address these problems, we focus on summarizing the dynamic oncogenic and tumor suppressive roles of autophagy and their relevant small-molecule drugs, which would provide a new clue to elucidate the oncosuppressive (survival or death) autophagic network as a potential therapeutic target.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Liu B,Wen X,Cheng Ydoi
10.1038/cddis.2013.422subject
Has Abstractpub_date
2013-10-31 00:00:00pages
e892issn
2041-4889pii
cddis2013422journal_volume
4pub_type
杂志文章,评审abstract::The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand bindi...
journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.170
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2010.21
更新日期:2010-05-20 00:00:00
abstract::The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate. The Notch pathway arises from the interaction of one of the Notch receptors (Notch1-4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, D...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
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更新日期:2016-12-08 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2014-05-22 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.489
更新日期:2017-11-09 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1417-4
更新日期:2019-02-20 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2016-08-04 00:00:00
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pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2018-08-28 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02845-8
更新日期:2020-08-13 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2013-09-12 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2015-12-10 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2017-04-13 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章,收录出版
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更新日期:2012-04-05 00:00:00