Axotomy induces axonogenesis in hippocampal neurons through STAT3.

Abstract:

:After axotomy of embryonic hippocampal neurons in vitro, some of the axotomized axons lose their identity, and new axons arise and grow. This axotomy-induced axonogenesis requires importin, suggesting that some injury-induced signals are transported via axons to elicit axonogenesis after axotomy. In this study, we show that STAT3 is activated in response to axotomy. Because STAT3 was co-immunoprecipitated with importin β in the axotomized neurons, we suggest that STAT3 is retrogradely transported as molecular cargo of importin α/β heterodimers. Indeed, inhibition of importin α binding with STAT3 resulted in the attenuation of axonogenesis. Silencing STAT3 blocked the axonogenesis, demonstrating that STAT3 is necessary for axotomy-induced axonogenesis. Furthermore, the overexpression of STAT3 enhanced axotomy-induced axonogenesis. Taken together, these results demonstrate that activation and retrograde transport of STAT3 in injured axons have key roles in the axotomy-induced axonogenesis of hippocampal neurons.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Ohara R,Fujita Y,Hata K,Nakagawa M,Yamashita T

doi

10.1038/cddis.2011.59

subject

Has Abstract

pub_date

2011-06-23 00:00:00

pages

e175

issn

2041-4889

pii

cddis201159

journal_volume

2

pub_type

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