Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.

abstract：:Kidney aging leads to an increased incidence of end-stage renal disease (ESRD) in the elderly, and aging is a complex biological process controlled by signaling pathways and transcription factors. Podocyte senescence plays a central role in injury resulting from kidney aging. Here, we demonstrated the critical role of...

journal_title：Cell death & disease

authors： Zhang L,Zhou F,Yu X,Zhu Y,Zhou Y,Liu J,Liu Y,Ma Q,Zhang Y,Wang W,Chen N

更新日期：2019-09-17 00:00:00

abstract：:Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to release and cell dea...

journal_title：Cell death & disease

authors： Hänggi K,Vasilikos L,Valls AF,Yerbes R,Knop J,Spilgies LM,Rieck K,Misra T,Bertin J,Gough PJ,Schmidt T,de Almodòvar CR,Wong WW

更新日期：2017-02-02 00:00:00

abstract：:miRNAs have emerged as a pivotal component of gene regulatory networks, mediating cytokines secretion, cell cycle, and differentiation regulation. However, how miRNAs collaborate with transcription factors and downstream effector proteins that determine the fate of ovarian cancer cells remains to be understood, especi...

journal_title：Cell death & disease

authors： Wu B,Zhang L,Yu Y,Lu T,Zhang Y,Zhu W,Song Q,Lv C,Guo J,Tian Y,Deng N

更新日期：2020-05-11 00:00:00

abstract：:The positive results of the apatinib phase III trial have cast new light on treatment for patients with advanced gastric cancer (GC). However, in terms of safety, apatinib toxicities may lead to a dose modification or treatment interruption. Therefore, proper intervention is urgently needed to help patients benefit fr...

journal_title：Cell death & disease

authors： Ma L,Wang Z,Xie M,Quan Y,Zhu W,Yang F,Zhao C,Fan Y,Fang N,Jiang H,Wang Q,Wang S,Zhou J,Chen X,Shu Y

更新日期：2020-03-05 00:00:00

abstract：:Cytokinesis is the last step of cell division and is concluded by the abscission of the intercellular bridge that connects two daughter cells. The tight regulation of cytokinesis completion is essential because cytokinesis failure is associated with various human diseases. Here, we report that iASPP, a member of the a...

journal_title：Cell death & disease

authors： Gao K,Zhang Y,Shi Q,Zhang J,Zhang L,Sun H,Jiao D,Zhao X,Tao H,Wei Y,Wang Y,Saiyin H,Zhao SM,Li Y,Zhang P,Wang C

更新日期：2018-05-01 00:00:00

abstract：:We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in terms of biological and gene expression responses. SRT501 and SRT2183 induced growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and r...

journal_title：Cell death & disease

authors： Scuto A,Kirschbaum M,Buettner R,Kujawski M,Cermak JM,Atadja P,Jove R

更新日期：2013-05-16 00:00:00

abstract：:In renal cell carcinoma, transglutaminase 2 (TGase 2) crosslinks p53 in autophagosomes, resulting in p53 depletion and the tumor's evasion of apoptosis. Inhibition of TGase 2 stabilizes p53 and induces tumor cells to enter apoptosis. This study explored the mechanism of TGase 2-dependent p53 degradation. We found that...

journal_title：Cell death & disease

authors： Kang JH,Lee JS,Hong D,Lee SH,Kim N,Lee WK,Sung TW,Gong YD,Kim SY

更新日期：2016-03-31 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...

journal_title：Cell death & disease

authors： Xiao K,He W,Guan W,Hou F,Yan P,Xu J,Zhou T,Liu Y,Xie L

更新日期：2020-10-15 00:00:00

abstract：:Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions in cerebral ischemia remain largely unknown. Through an lncRNA array analysis in a rat model of focal cerebral ischemia/reperfusion (I/R), we have identified CAMK2D-associ...

journal_title：Cell death & disease

authors： Xu Q,Deng F,Xing Z,Wu Z,Cen B,Xu S,Zhao Z,Nepomuceno R,Bhuiyan MI,Sun D,Wang QJ,Ji A

更新日期：2016-03-31 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, whi...

journal_title：Cell death & disease

authors： Yang L,Chao J,Kook YH,Gao Y,Yao H,Buch SJ

更新日期：2013-12-12 00:00:00

abstract：:Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this study, we found that U...

journal_title：Cell death & disease

authors： Gong P,Qiao F,Wu H,Cui H,Li Y,Zheng Y,Zhou M,Fan H

更新日期：2018-11-21 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Epigenetic alteration of tumor suppression gene is one of the most significant indicators in human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel ESCC hypermethylation biomarker ZNF132 by integrative computational analysis to comprehensive genome-wide DNA methylation microarray dataset...

journal_title：Cell death & disease

authors： Jiang D,He Z,Wang C,Zhou Y,Li F,Pu W,Zhang X,Feng X,Zhang M,Yecheng X,Xu Y,Jin L,Guo S,Wang J,Wang M

更新日期：2018-12-18 00:00:00

abstract：:ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechan...

journal_title：Cell death & disease

authors： Chen Z,Wu C,Liu Y,Li H,Zhu Y,Huang C,Lin H,Qiao Q,Huang M,Zhu Q,Wang L

更新日期：2020-08-22 00:00:00

abstract：:Current preclinical models in tumor biology are limited in their ability to recapitulate relevant (patho-) physiological processes, including autophagy. Three-dimensional (3D) growth cultures have frequently been proposed to overcome the lack of correlation between two-dimensional (2D) monolayer cell cultures and huma...

journal_title：Cell death & disease

authors： Bingel C,Koeneke E,Ridinger J,Bittmann A,Sill M,Peterziel H,Wrobel JK,Rettig I,Milde T,Fernekorn U,Weise F,Schober A,Witt O,Oehme I

更新日期：2017-08-24 00:00:00

abstract：:Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage liver diseases as hepatocellular carcinoma and cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation and liver fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The...

journal_title：Cell death & disease

authors： Li Z,Chen B,Dong W,Kong M,Fan Z,Yu L,Wu D,Lu J,Xu Y

更新日期：2019-11-27 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are frequently found near pancreatic cancer cells, but it is uncertain whether they are involved in pancreatic cancer progression and the Warburg effect. Here, we show that CCL18 secreted by TAMs facilitates malignant progression and induced a glycolytic phenotype in pancreatic canc...

journal_title：Cell death & disease

authors： Ye H,Zhou Q,Zheng S,Li G,Lin Q,Wei L,Fu Z,Zhang B,Liu Y,Li Z,Chen R

更新日期：2018-05-01 00:00:00

abstract：:We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone...

journal_title：Cell death & disease

authors： Li D,Wang WJ,Wang YZ,Wang YB,Li YL

更新日期：2019-10-03 00:00:00

abstract：:Cancer cells including glioblastoma have typically evolved multiple mechanisms to escape programmed cell death in order to maintain their survival. Defects in cell death mechanisms not only facilitate tumorigenesis but also ensure resistance to current anticancer therapies. This emphasizes that targeting cell death pa...

journal_title：Cell death & disease

authors： Fulda S

更新日期：2018-01-25 00:00:00

abstract：:Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were therefore investig...

journal_title：Cell death & disease

authors： Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet AG,Oates M,Slupsky JR,Pettitt AR

更新日期：2012-08-16 00:00:00

abstract：:The selenoprotein thioredoxin reductase 1 (TrxR1) has several key roles in cellular redox systems and reductive pathways. Here we discovered that an evolutionarily conserved and surface-exposed tryptophan residue of the enzyme (Trp114) is excessively reactive to oxidation and exerts regulatory functions. The results i...

journal_title：Cell death & disease

authors： Xu J,Eriksson SE,Cebula M,Sandalova T,Hedström E,Pader I,Cheng Q,Myers CR,Antholine WE,Nagy P,Hellman U,Selivanova G,Lindqvist Y,Arnér ES

更新日期：2015-01-22 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix producti...

journal_title：Cell death & disease

authors： Chen X,Shi C,Cao H,Chen L,Hou J,Xiang Z,Hu K,Han X

更新日期：2018-05-29 00:00:00

abstract：:Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...

journal_title：Cell death & disease

authors： Huang RL,Sun Y,Ho CK,Liu K,Tang QQ,Xie Y,Li Q

更新日期：2018-02-02 00:00:00

abstract：:SHP2 participates in multiple signaling events by mediating T-cell development and function, and regulates cytokine-dependent granulopoiesis. To explore whether and how SHP2 can regulate bone-marrow eosinophil differentiation, we investigate the contribution of SHP2 in the bone-marrow eosinophil development in allergi...

journal_title：Cell death & disease

authors： Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH

更新日期：2016-04-07 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report...

journal_title：Cell death & disease

authors： Lee SJ,Lee KB,Son YH,Shin J,Lee JH,Kim HJ,Hong AY,Bae HW,Kwon MA,Lee WJ,Kim JH,Lee DH,Jeong EM,Kim IG

更新日期：2017-10-26 00:00:00

abstract：:We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...

journal_title：Cell death & disease

authors： Van de Casteele M,Leuckx G,Baeyens L,Cai Y,Yuchi Y,Coppens V,De Groef S,Eriksson M,Svensson C,Ahlgren U,Ahnfelt-Rønne J,Madsen OD,Waisman A,Dor Y,Jensen JN,Heimberg H

更新日期：2013-03-07 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:We previously reported that marchantin M (Mar) is an active agent to induce apoptosis in human prostate cancer (PCa), but the molecular mechanisms of action remain largely unknown. Here, we demonstrate that Mar potently inhibited chymotrypsin-like and peptidyl-glutamyl peptide-hydrolyzing activities of 20S proteasome ...

journal_title：Cell death & disease

authors： Jiang H,Sun J,Xu Q,Liu Y,Wei J,Young CY,Yuan H,Lou H

更新日期：2013-08-08 00:00:00