Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment.

abstract：:Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the ...

journal_title：Cell death & disease

authors： Katata Y,Inoue SI,Asao A,Kobayashi S,Terui H,Inoue-Shibui A,Abe T,Niihori T,Aiba S,Ishii N,Kure S,Aoki Y

更新日期：2020-08-13 00:00:00

abstract：:A major hallmark of Parkinson's disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necroptosis is a regulated process of cell death triggered by RIPK1. Although the pathophysiology of PD has been st...

journal_title：Cell death & disease

authors： Hu YB,Zhang YF,Wang H,Ren RJ,Cui HL,Huang WY,Cheng Q,Chen HZ,Wang G

更新日期：2019-08-05 00:00:00

abstract：:Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it may enhance anti-tumor and antiviral effects of CD8 T cells. Here we investigate the mechanisms by which IFNγ mediates CD8 T-cell cytotoxic f...

journal_title：Cell death & disease

authors： Bhat P,Leggatt G,Waterhouse N,Frazer IH

更新日期：2017-06-01 00:00:00

abstract：:Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2-knockout or -overexpressing primary proliferating...

journal_title：Cell death & disease

authors： Bean C,Verma NK,Yamamoto DL,Chemello F,Cenni V,Filomena MC,Chen J,Bang ML,Lanfranchi G

更新日期：2014-01-16 00:00:00

abstract：:Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of several toxic and damaging molecules. These are necessary to figh...

journal_title：Cell death & disease

authors： Cauwels A,Rogge E,Vandendriessche B,Shiva S,Brouckaert P

更新日期：2014-03-06 00:00:00

abstract：:Since publication of this paper, the authors have noticed that there were errors in Fig. 2A (the GAPDH of Mel-CV, Mel-CV.S, Mel-RMu and Mel-RMu.S), Fig. 2C (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3F (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3J(the GAPDH of Mel-RMu.S), Fig. 5C (the ERK1/2 of patient#3(post)), and...

journal_title：Cell death & disease

authors： Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XD

更新日期：2019-03-05 00:00:00

abstract：:Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still controversial and th...

journal_title：Cell death & disease

authors： Park E,Chung SW

更新日期：2019-10-28 00:00:00

abstract：:Following publication of this article, it was brought to our attention that there was a typo in the References (reference number 43) whereby the first author's name was misspelled. The correct citation is provided below. We apologize for the inconvenience. ...

journal_title：Cell death & disease

authors： Wang LH,Baker NE

更新日期：2019-10-22 00:00:00

abstract：:Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor micr...

journal_title：Cell death & disease

authors： Wang G,Wang Q,Liang N,Xue H,Yang T,Chen X,Qiu Z,Zeng C,Sun T,Yuan W,Liu C,Chen Z,He X

更新日期：2020-05-04 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...

journal_title：Cell death & disease

authors： Ma Y,Yang Q,Zhong Z,Liang W,Zhang L,Yang Y,Ding G

更新日期：2018-02-07 00:00:00

abstract：:Mammalian female fertility is limited by the number and quality of oocytes in the ovarian reserve. The number of oocytes is finite since all germ cells cease proliferation to become oocytes in fetal life. Moreover, 70-80% of the initial oocyte population is eliminated during fetal and neonatal development, restricting...

journal_title：Cell death & disease

authors： Liu X,Castle V,Taketo T

更新日期：2019-10-17 00:00:00

abstract：:New bone anabolic agents for the effective treatment of bone metabolic diseases like osteoporosis are of high clinical demand. In the present study, we reveal the function of salt-inducible kinase 1 (SIK1) in regulating osteoblast differentiation. Gene knockdown of SIK1 but not of SIK2 or SIK3 expression in primary pr...

journal_title：Cell death & disease

authors： Kim MK,Kwon JO,Song MK,Kim B,Kim H,Lee ZH,Koo SH,Kim HH

更新日期：2019-10-31 00:00:00

abstract：:Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

journal_title：Cell death & disease

authors： Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

更新日期：2011-12-08 00:00:00

abstract：:Long non-coding RNA (lncRNA) plays an important role in the development of human malignant tumours. Recently, an increasing number of lncRNAs have been identified and investigated in a variety of tumours. However, the expression pattern and biological function of lncRNAs in cervical cancer still remain largely unexplo...

journal_title：Cell death & disease

authors： Rui X,Xu Y,Jiang X,Ye W,Huang Y,Jiang J

更新日期：2018-12-05 00:00:00

abstract：:Estrogen-dependent breast cancer is often treated with the aromatase inhibitors or estrogen receptor (ER) antagonists. Tamoxifen as a major ER antagonist is usually used to treat those patients with ERα-positive breast cancer. However, a majority of patients with ERα positive fail to respond to tamoxifen due to the pr...

journal_title：Cell death & disease

authors： Zhu J,Zou Z,Nie P,Kou X,Wu B,Wang S,Song Z,He J

更新日期：2016-11-03 00:00:00

abstract：:Disrupting microtubule dynamics with spindle poisons activates the spindle-assembly checkpoint (SAC) and induces mitotic cell death. However, mitotic exit can occur prematurely without proper chromosomal segregation or cytokinesis by a process termed mitotic slippage. It remains controversial whether mitotic slippage ...

journal_title：Cell death & disease

authors： Zeng X,Xu WK,Lok TM,Ma HT,Poon RYC

更新日期：2019-04-05 00:00:00

abstract：:Metastasis is the leading cause of death for colorectal cancer (CRC). However, the protein transport process involved in CRC metastasis remains unclear. In this report, we use whole-exome sequencing and bioinformatics analysis to identify somatic mutations in CRC samples and found mutations of the protein transport ge...

journal_title：Cell death & disease

authors： Yang C,Chen N,Li X,Lu D,Hou Z,Li Y,Jin Y,Gu J,Yin Y

更新日期：2020-03-02 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

journal_title：Cell death & disease

authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

更新日期：2016-02-04 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence in Situ Hybridization and dual luciferase rep...

journal_title：Cell death & disease

authors： Jin X,Gao J,Zheng R,Yu M,Ren Y,Yan T,Huang Y,Li Y

更新日期：2020-02-13 00:00:00

abstract：:ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechan...

journal_title：Cell death & disease

authors： Chen Z,Wu C,Liu Y,Li H,Zhu Y,Huang C,Lin H,Qiao Q,Huang M,Zhu Q,Wang L

更新日期：2020-08-22 00:00:00

abstract：:Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8+ cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OVA-specific CD8+ CTLs ...

journal_title：Cell death & disease

authors： Wakabayashi A,Shimizu M,Shinya E,Takahashi H

更新日期：2018-05-24 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas, and participate in the formation of the tumor microenvironment. They have recently been isolated from colorectal cancer tissues, and are implicated in the growth, invasion, and metastasis of cancer cells. However, the roles and deta...

journal_title：Cell death & disease

authors： Zhang X,Hu F,Li G,Li G,Yang X,Liu L,Zhang R,Zhang B,Feng Y

更新日期：2018-01-18 00:00:00

abstract：:Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase-dependent pathway involving cytosolic acidification and alkalinization of tumour pH. In this paper, we further investigated the mechanisms of ESOM-induc...

journal_title：Cell death & disease

authors： Marino ML,Fais S,Djavaheri-Mergny M,Villa A,Meschini S,Lozupone F,Venturi G,Della Mina P,Pattingre S,Rivoltini L,Codogno P,De Milito A

更新日期：2010-10-21 00:00:00

abstract：:Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chrom...

journal_title：Cell death & disease

authors： Li Y,He Y,Liang Z,Wang Y,Chen F,Djekidel MN,Li G,Zhang X,Xiang S,Wang Z,Gao J,Zhang MQ,Chen Y

更新日期：2018-02-08 00:00:00

abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems. As Hipk2(-/-) mice show behavioral abnormalities consistent with cerebellar dysfunction, we investigated...

journal_title：Cell death & disease

authors： Anzilotti S,Tornincasa M,Gerlini R,Conte A,Brancaccio P,Cuomo O,Bianco G,Fusco A,Annunziato L,Pignataro G,Pierantoni GM

更新日期：2015-12-03 00:00:00

abstract：:The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...

journal_title：Cell death & disease

authors： Yao M,Shi X,Li Y,Xiao Y,Butler W,Huang Y,Du L,Wu T,Bian X,Shi G,Ye D,Fu G,Wang J,Ren S

更新日期：2020-08-15 00:00:00

abstract：:Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a preconditioning strateg...

journal_title：Cell death & disease

authors： Francis KR,Wei L

更新日期：2010-01-01 00:00:00