Abstract:
:Since publication of this paper, the authors have noticed that there were errors in Fig. 2A (the GAPDH of Mel-CV, Mel-CV.S, Mel-RMu and Mel-RMu.S), Fig. 2C (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3F (the GAPDH of Mel-CV.S and Mel-RMu.S), Fig. 3J(the GAPDH of Mel-RMu.S), Fig. 5C (the ERK1/2 of patient#3(post)), and Fig. 5F (the RIP1 of Mel-CV.S and Mel-RMu.S, the GAPDH of Mel-CV and Mel-RMu). As a result of the misfiling of the data during preparation of figures, incorrect images were inadvertently inserted in these figures. The correct figures are given below. The corrections do not alter the conclusions of the paper.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XDdoi
10.1038/s41419-019-1301-2subject
Has Abstractpub_date
2019-03-05 00:00:00pages
225issue
3issn
2041-4889pii
10.1038/s41419-019-1301-2journal_volume
10pub_type
已发布勘误abstract::MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression by binding to the three untranslated regions of their target mRNAs. Deregulations of miRs were shown to play pivotal roles in tumorigenesis and progression. Recent research efforts have been devoted to translating these basic discoverie...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2014.270
更新日期:2014-07-17 00:00:00
abstract::Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.24
更新日期:2017-02-09 00:00:00
abstract::Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA1). Additionally, a...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02743-z
更新日期:2020-07-16 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor survival. It is urgent to search for new efficient drugs with good stability and safety for clinical therapy. This study aims to identify potential anticancer drugs from a compound library consisting of 429 natural products....
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2730-7
更新日期:2020-07-13 00:00:00
abstract::Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of Leydig cells expose...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1728-5
更新日期:2019-06-20 00:00:00
abstract::In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and to exhibit anticancer effects. Graviola tree is an evergreen tree with its extracts (leafs and see...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0772-x
更新日期:2018-07-09 00:00:00
abstract::Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.533
更新日期:2014-01-16 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targeted therapies for pat...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.391
更新日期:2014-10-02 00:00:00
abstract::Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.299
更新日期:2013-08-15 00:00:00
abstract::The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin-proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated degradation of E6/E7 ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.477
更新日期:2014-11-13 00:00:00
abstract::Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected temporal dynamic of gene c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02860-9
更新日期:2020-08-14 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) pathway has been shown to be involved in both neurodevelopment and neurodegeneration. c-Jun N-terminal kinase (JNK), a MAPK important in retinal development and after optic nerve crush injury, is regulated by two upstream kinases: MKK4 and MKK7. The specific requirements of ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1079-7
更新日期:2018-10-26 00:00:00
abstract::Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection that leads to uncontrolled inflammatory response followed by immunosuppression. However, despite the high mortality rate, no specific treatment modality or drugs with high efficacy is available for sepsis to date....
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/s41419-019-2015-1
更新日期:2019-10-14 00:00:00
abstract::Phosphatase and tensin homolog (PTEN) regulates apoptosis and axonal growth in the developing and adult central nervous system (CNS). Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, highlighted by the find...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1802-z
更新日期:2019-07-29 00:00:00
abstract::Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.230
更新日期:2015-09-17 00:00:00
abstract::β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.439
更新日期:2014-10-16 00:00:00
abstract::Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8+ cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OVA-specific CD8+ CTLs ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0665-z
更新日期:2018-05-24 00:00:00
abstract::The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington's disease (HD), a neurodegenerative disorder caused by neural death due to expa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02754-w
更新日期:2020-07-18 00:00:00
abstract::The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02856-5
更新日期:2020-08-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0804-6
更新日期:2018-07-03 00:00:00
abstract::Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02845-8
更新日期:2020-08-13 00:00:00
abstract::Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1241-2
更新日期:2019-01-10 00:00:00
abstract::The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metabolism proteins, inclu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1951-0
更新日期:2019-09-24 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2289-3
更新日期:2020-02-04 00:00:00
abstract::Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially of the lead compound Triapine. During the last years, a novel subclass of anticancer thiosemicarbazones has attracted substantial interest ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1102-z
更新日期:2018-10-15 00:00:00
abstract::Bu-Shen-Ning-Xin Decoction (BSNXD) administration has alleviated the early pathologic damage of atherosclerosis by inhibiting the adhesion molecule expression and upregulating the estrogen receptor (ER) β expression in endothelial cells, and increasing the serum nitric oxide (NO) level without any effect on serum lipi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.66
更新日期:2013-03-21 00:00:00
abstract::The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate. The Notch pathway arises from the interaction of one of the Notch receptors (Notch1-4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, D...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/cddis.2016.408
更新日期:2016-12-08 00:00:00
abstract::STAT1, which carries tumor suppressor functions in several models, consists of two isoforms, namely STAT1α and STAT1β. The biological function and significance of STAT1β has never been examined in human cancer. We examined STAT1β function in esophageal squamous cell carcinoma (ESCC) by transfecting a STAT1β gene into ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.481
更新日期:2017-10-05 00:00:00
abstract::Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) poses a serious threat to the world's public health yet without a cure. Certain JEV-infected neural cells express a subset of previously identified intrinsic antiviral interferon stimulated genes (ISGs), indicating brain cells retain autonomous ant...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0763-y
更新日期:2018-06-18 00:00:00
abstract::The incidence of malignant melanoma has continued to rise during the past decades. However, in the last few years, treatment protocols have significantly been improved thanks to a better understanding of the key oncogenes and signaling pathways involved in its pathogenesis and progression. Anticancer therapy would eit...
journal_title:Cell death & disease
pub_type: 杂志文章,评审
doi:10.1038/s41419-017-0059-7
更新日期:2018-01-25 00:00:00