Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling.

abstract：:The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression of hepatocellular carcinoma (HCC). However, regulation of the DOR in HCC remains poorly defined. We found that miR-874 was identified as a negative regulator of the DOR, which is a direct and functional target o...

journal_title：Cell death & disease

authors： Zhang Y,Wei Y,Li X,Liang X,Wang L,Song J,Zhang X,Zhang C,Niu J,Zhang P,Ren Z,Tang B

更新日期：2018-01-26 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

journal_title：Cell death & disease

authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

更新日期：2020-10-22 00:00:00

abstract：:Despite successful antiretroviral drug therapy, a subset of human immunodeficiency virus-1 (HIV)-positive individuals still display synaptodendritic simplifications and functional cognitive impairments referred to as HIV-associated neurocognitive disorders (HANDs). The neurological damage observed in HAND subjects can...

journal_title：Cell death & disease

authors： Wenzel ED,Speidell A,Flowers SA,Wu C,Avdoshina V,Mocchetti I

更新日期：2019-09-12 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is an important mitotic kinase and its expression is tightly regulated in the cell cycle and in the DNA damage response. PLK1 expression is previously shown to be suppressed by p53 and/or p21. Here, we demonstrate that the CCAAT box in the PLK1 promoter is pivotal for p53/p21-mediated PLK1 re...

journal_title：Cell death & disease

authors： Lin YC,Chen YN,Lin KF,Wang FF,Chou TY,Chen MY

更新日期：2014-01-09 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been identified as potential prognostic tools and therapeutic biomarkers for a variety of human cancers. However, the functional roles and underlying mechanisms of key lncRNAs affecting laryngeal squamous cell carcinomas (LSCCs) are largely unknown. Here, we adopted a novel subpathwa...

journal_title：Cell death & disease

authors： Li X,Xu F,Meng Q,Gong N,Teng Z,Xu R,Zhao M,Xia M

更新日期：2020-06-18 00:00:00

abstract：:Soluble Axl (sAxl) was recently shown to be strongly released into the blood during liver fibrogenesis and hepatocellular carcinoma suggesting sAxl as a biomarker of liver diseases. In this study we are the first to evaluate sAxl in human serum in comparison to Enhanced Liver Fibrosis (ELF) test and transient elastogr...

journal_title：Cell death & disease

authors： Staufer K,Dengler M,Huber H,Marculescu R,Stauber R,Lackner C,Dienes HP,Kivaranovic D,Schachner C,Zeitlinger M,Wulkersdorfer B,Rauch P,Prager G,Trauner M,Mikulits W

更新日期：2017-10-26 00:00:00

abstract：:This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...

journal_title：Cell death & disease

authors： Li L,Liu J,Xu M,Yu H,Lv C,Cao F,Wang Z,Fu Y,Zhang M,Meng H,Zhang X,Kang L,Zhang Z,Li J,Feng J,Lian X,Yu L,Zhou J

更新日期：2020-03-30 00:00:00

abstract：:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction ...

journal_title：Cell death & disease

authors： Park B,Chang S,Lee GJ,Kang B,Kim JK,Park H

更新日期：2019-01-08 00:00:00

abstract：:The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metabolism proteins, inclu...

journal_title：Cell death & disease

authors： Zhao P,Qian C,Chen YJ,Sheng Y,Ke Y,Qian ZM

更新日期：2019-09-24 00:00:00

abstract：:Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood. The purpose of current study was to investigate the role of Mas receptor in lipid-induced kidney injury. In mice fed with high-fat diet (HFD), the protein abu...

journal_title：Cell death & disease

authors： Kong Y,Zhao X,Qiu M,Lin Y,Feng P,Li S,Liang B,Zhu Q,Huang H,Li C,Wang W

更新日期：2021-01-21 00:00:00

abstract：:Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes l...

journal_title：Cell death & disease

authors： Huang X,Xiao S,Zhu X,Yu Y,Cao M,Zhang X,Li S,Zhu W,Wu F,Zheng X,Jin L,Xie C,Huang X,Zou P,Li X,Cui R

更新日期：2020-09-22 00:00:00

abstract：:The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was pos...

journal_title：Cell death & disease

authors： Yu Y,Zhao D,Li K,Cai Y,Xu P,Li R,Li J,Chen X,Chen P,Cui G

更新日期：2020-04-24 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...

journal_title：Cell death & disease

authors： Zhao K,Hao H,Liu J,Tong C,Cheng Y,Xie Z,Zang L,Mu Y,Han W

更新日期：2015-09-17 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) of podocytes had been reported to be involved in the glomerular fibrosis in diabetic kidney diseases, which was regulated by TGFβ and NFκB pathways. And apelin, an adipokine which is upregulated in diabetic kidney diseases, was reported to be negatively correlated to TGFβ in...

journal_title：Cell death & disease

authors： Yin J,Wang Y,Chang J,Li B,Zhang J,Liu Y,Lai S,Jiang Y,Li H,Zeng X

更新日期：2018-10-09 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent ...

journal_title：Cell death & disease

authors： Cao YY,Yu J,Liu TT,Yang KX,Yang LY,Chen Q,Shi F,Hao JJ,Cai Y,Wang MR,Lu WH,Zhang Y

更新日期：2018-01-16 00:00:00

abstract：:Enhanced SNHG1 (small nucleolar RNA host gene 1) expression has been found to play a critical role in the initiation and progression of hepatocellular carcinoma (HCC) with its detailed mechanism largely unknown. In this study, we show that SNHG1 promotes the HCC progression through epigenetically silencing CDKN1A and ...

journal_title：Cell death & disease

authors： Li B,Li A,You Z,Xu J,Zhu S

更新日期：2020-10-02 00:00:00

abstract：:Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T cells associated with chronic infection by human T-cell lymphotropic virus type-1 (HTLV-1). ATLL patients with aggressive subtypes have dismal outcomes. We demonstrate that ATLL cells co-opt an early checkpoint within the tumor necrosis factor receptor ...

journal_title：Cell death & disease

authors： Xu X,Kalac M,Markson M,Chan M,Brody JD,Bhagat G,Ang RL,Legarda D,Justus SJ,Liu F,Li Q,Xiong H,Ting AT

更新日期：2020-02-05 00:00:00

abstract：:The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes...

journal_title：Cell death & disease

authors： Yang J,Kim KS,Iyirhiaro GO,Marcogliese PC,Callaghan SM,Qu D,Kim WJ,Slack RS,Park DS

更新日期：2019-02-12 00:00:00

abstract：:Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...

journal_title：Cell death & disease

authors： Rocchi A,Sacchetti S,De Fusco A,Giovedi S,Parisi B,Cesca F,Höltje M,Ruprecht K,Ahnert-Hilger G,Benfenati F

更新日期：2019-11-14 00:00:00

abstract：:Gastric epithelial cells (GECs) provide the first point of contact of the host by Helicobacter pylori (H. pylori), and the interaction between H. pylori and GECs plays a critical role in H. pylori-associated diseases. Aberrant expression of transcription factors (TFs) contributes to the pathogenesis of inflammatory di...

journal_title：Cell death & disease

authors： Teng Y,Cang B,Mao F,Chen W,Cheng P,Peng L,Luo P,Lu D,You N,Zou Q,Zhuang Y

更新日期：2020-07-01 00:00:00

abstract：:Interleukin-17 receptor B (IL-17RB), a member of the IL-17 receptor family activated by IL-17B/IL-17E, has been shown to be involved in inflammatory diseases. However, the regulation and function of IL-17RB in Helicobacter pylori (H. pylori) infection, especially in the early-phase is still unknown. Here, we found tha...

journal_title：Cell death & disease

authors： Teng YS,Liu YG,Chen XH,Wang TT,Cheng P,Lv YP,Kong H,Mao FY,Hao CJ,Yang SM,Chen W,Zhang JY,Peng LS,Han B,Ma Q,Han J,Zou QM,Zhuang Y

更新日期：2019-01-28 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:We explored the activity of SIRT1 activators (SRT501 and SRT2183) alone and in combination with panobinostat in a panel of malignant lymphoid cell lines in terms of biological and gene expression responses. SRT501 and SRT2183 induced growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and r...

journal_title：Cell death & disease

authors： Scuto A,Kirschbaum M,Buettner R,Kujawski M,Cermak JM,Atadja P,Jove R

更新日期：2013-05-16 00:00:00

abstract：:DEP-domain containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, has essential roles in several processes, including cell growth, metabolism, apoptosis, and immunity. DEPTOR expression has been shown to be diversely controlled at transcriptional levels in cell- and context-specific manners. However, ...

journal_title：Cell death & disease

authors： Cui D,Dai X,Gong L,Chen X,Wang L,Xiong X,Zhao Y

更新日期：2020-11-12 00:00:00

abstract：:Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dependent on BCL-2 ass...

journal_title：Cell death & disease

authors： McCoy F,Hurwitz J,McTavish N,Paul I,Barnes C,O'Hagan B,Odrzywol K,Murray J,Longley D,McKerr G,Fennell DA

更新日期：2010-12-16 00:00:00

abstract：:In this study, the roles of p53 in impaired spermatogenic male germ cells of p53-deficient medaka were investigated by analyzing histological changes, and gene expressions of 42Sp50, Oct 4 and vitellogenin (VTG2) by RT-PCR or in situ hybridization in the testes. We found that a small number of oocyte-like cells (testi...

journal_title：Cell death & disease

authors： Yasuda T,Oda S,Li Z,Kimori Y,Kamei Y,Ishikawa T,Todo T,Mitani H

更新日期：2012-10-04 00:00:00

abstract：:Vascular endothelial growth factor receptor (VEGFR) and neuropilins (NRPs), a co-receptor of VEGF, play a key role in the formation and development of blood vessels and in tumour growth and metastasis. However, whether VEGFR1/2 and NRP1 are regulated by the same upstream mechanism is unclear, especially in gastric can...

journal_title：Cell death & disease

authors： Mei B,Chen J,Yang N,Peng Y

更新日期：2020-04-17 00:00:00

abstract：:The majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicl...

journal_title：Cell death & disease

authors： Denton D,Xu T,Dayan S,Nicolson S,Kumar S

更新日期：2019-02-08 00:00:00

abstract：:Obesity has been associated with increased incidence and mortality of a wide variety of human cancers including colorectal cancer. However, the molecular mechanism by which adipocytes regulate the metabolism of colon cancer cells remains elusive. In this study, we showed that adipocytes isolated from adipose tissues o...

journal_title：Cell death & disease

authors： Wen YA,Xing X,Harris JW,Zaytseva YY,Mitov MI,Napier DL,Weiss HL,Mark Evers B,Gao T

更新日期：2017-02-02 00:00:00