Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy.

abstract：:Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...

journal_title：Cell death & disease

authors： Zhou J,Lei B,Li H,Zhu L,Wang L,Tao H,Mei S,Li F

更新日期：2017-02-09 00:00:00

abstract：:Effective management of breast cancer depends on early diagnosis and proper monitoring of patients' response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years...

journal_title：Cell death & disease

authors： Hamam R,Hamam D,Alsaleh KA,Kassem M,Zaher W,Alfayez M,Aldahmash A,Alajez NM

更新日期：2017-09-07 00:00:00

abstract：:Chromatin conformation plays a key role in regulating gene expression and controlling cell differentiation. However, the whole-genome chromatin conformation changes that occur during leukemia cell differentiation are poorly understood. Here, we characterized the changes in chromatin conformation, histone states, chrom...

journal_title：Cell death & disease

authors： Li Y,He Y,Liang Z,Wang Y,Chen F,Djekidel MN,Li G,Zhang X,Xiang S,Wang Z,Gao J,Zhang MQ,Chen Y

更新日期：2018-02-08 00:00:00

abstract：:This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl4) in a murine model and the underlying molecular mechanisms. Ninety-six mice were randomly divided into the control (n = 8), CQ (n = 8), CCl4 (n = 40), and CCl4 + CQ (n = 40) treatment gro...

journal_title：Cell death & disease

authors： Dai C,Xiao X,Li D,Tun S,Wang Y,Velkov T,Tang S

更新日期：2018-11-26 00:00:00

abstract：:Chemoresistance is one of the leading causes that contributes to tumor relapse and poor patient outcome after several rounds of drug therapy. The causes of chemoresistance are multi-factorial. Ultimately, it is the balance of pro- and anti-apoptotic activities in the cells. We have previously reported links between PO...

journal_title：Cell death & disease

authors： Weng T,Koh CG

更新日期：2017-09-14 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...

journal_title：Cell death & disease

authors： Kim JY,Shin KK,Lee AL,Kim YS,Park HJ,Park YK,Bae YC,Jung JS

更新日期：2014-08-21 00:00:00

abstract：:Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+...

journal_title：Cell death & disease

authors： Ousingsawat J,Wanitchakool P,Schreiber R,Kunzelmann K

更新日期：2018-02-20 00:00:00

abstract：:The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...

journal_title：Cell death & disease

authors： Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

更新日期：2018-07-16 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...

journal_title：Cell death & disease

authors： Gatta V,D'Aurora M,Granzotto A,Stuppia L,Sensi SL

更新日期：2014-02-13 00:00:00

abstract：:It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1-adrenergic receptor autoantibodies (β1-AABs) decreased myocardial autophagy, but the role of decreased auto...

journal_title：Cell death & disease

authors： Wang L,Li Y,Ning N,Wang J,Yan Z,Zhang S,Jiao X,Wang X,Liu H

更新日期：2018-03-14 00:00:00

abstract：:Mechanisms underlying the generation of induced pluripotent stem cells (iPSC) and keeping iPSC stability remain to be further defined. Accumulated evidences showed that iPSC reprogramming may be controlled by the cell-division-rate-dependent model. Here we reported effects of absence of mouse p27 or p18 on iPSC genera...

journal_title：Cell death & disease

authors： Zhan Z,Song L,Zhang W,Gu H,Cheng H,Zhang Y,Yang Y,Ji G,Feng H,Cheng T,Li Y

更新日期：2019-03-20 00:00:00

abstract：:Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly reduced infarct size, decreased troponin T levels and improved cardiac...

journal_title：Cell death & disease

authors： Wu QF,Qian C,Zhao N,Dong Q,Li J,Wang BB,Chen L,Yu L,Han B,Du YM,Liao YH

更新日期：2017-05-25 00:00:00

abstract：:The incidence of malignant melanoma has continued to rise during the past decades. However, in the last few years, treatment protocols have significantly been improved thanks to a better understanding of the key oncogenes and signaling pathways involved in its pathogenesis and progression. Anticancer therapy would eit...

journal_title：Cell death & disease

authors： Mattia G,Puglisi R,Ascione B,Malorni W,Carè A,Matarrese P

更新日期：2018-01-25 00:00:00

abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

journal_title：Cell death & disease

authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

更新日期：2013-09-12 00:00:00

abstract：:UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine production in keratinocytes. However, the downstream protein target(s) that link UV radiation to the activation of signaling pathways responsible for cytokine expression have not been fully elucidated. In this study, we report...

journal_title：Cell death & disease

authors： Lee SJ,Lee KB,Son YH,Shin J,Lee JH,Kim HJ,Hong AY,Bae HW,Kwon MA,Lee WJ,Kim JH,Lee DH,Jeong EM,Kim IG

更新日期：2017-10-26 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:The voltage-gated K+ channel has key roles in the vasculature and in atrial excitability and contributes to apoptosis in various tissues. In this study, we have explored its regulation by carbon monoxide (CO), a product of the cytoprotective heme oxygenase enzymes, and a recognized toxin. CO inhibited recombinant Kv1....

journal_title：Cell death & disease

authors： Al-Owais MM,Hettiarachchi NT,Boyle JP,Scragg JL,Elies J,Dallas ML,Lippiat JD,Steele DS,Peers C

更新日期：2017-11-02 00:00:00

abstract：:Methamphetamine (METH), a commonly used controlled substance, is known to exacerbate neuropathological dysfunction in HIV-infected individuals. The neuropathological manifestation results from cell death or dysfunction in the central nervous system (CNS) wherein autophagy is expected to have an important role. Autopha...

journal_title：Cell death & disease

authors： Cao L,Fu M,Kumar S,Kumar A

更新日期：2016-10-20 00:00:00

abstract：:MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our st...

journal_title：Cell death & disease

authors： Chen X,Zeng K,Xu M,Liu X,Hu X,Xu T,He B,Pan Y,Sun H,Wang S

更新日期：2019-02-12 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are conserved protein kinases that regulate a variety of important cellular signaling pathways. Among them, c-Jun N-terminal kinases (JNK) are known to be activated by various environmental stresses including virus infections. Previously, activation of the JNK pathway has been...

journal_title：Cell death & disease

authors： Fung TS,Liu DX

更新日期：2017-12-13 00:00:00

abstract：:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction ...

journal_title：Cell death & disease

authors： Park B,Chang S,Lee GJ,Kang B,Kim JK,Park H

更新日期：2019-01-08 00:00:00

abstract：:Thioredoxin-interacting protein (TXNIP) is involved in oxidative stress and apoptosis in diabetic retinopathy. However, the role of TXNIP in the removal of damaged mitochondria (MT) via mitophagy, a process of macroautophagy, remains unexplored. Here we investigate the associated cellular and molecular mechanisms unde...

journal_title：Cell death & disease

authors： Devi TS,Somayajulu M,Kowluru RA,Singh LP

更新日期：2017-05-11 00:00:00

abstract：:The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion o...

journal_title：Cell death & disease

authors： Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J

更新日期：2018-02-14 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While studies have been conducted in these research areas, the pathogenesis and mechanisms of MetS remain debatable. Lines of evidence show that ph...

journal_title：Cell death & disease

authors： Menikdiwela KR,Ramalingam L,Rasha F,Wang S,Dufour JM,Kalupahana NS,Sunahara KKS,Martins JO,Moustaid-Moussa N

更新日期：2020-02-03 00:00:00

abstract：:Many recent studies have uncovered the necessary role for the receptor-interacting protein kinase 1 (RIP1) in regulating apoptosis and necrosis that cells undergo in response to various cellular stresses. However, the functional significance of RIP1 in promoting cancer cells survival remains poorly understood. Here, w...

journal_title：Cell death & disease

authors： Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XD

更新日期：2018-06-07 00:00:00

abstract：:SOX4, a member of the SOX (sex-determining region Y-related HMG box) transcription factor family, has been reported to be abnormally expressed in a wide variety of cancers, and to exert a pleiotropic function. However, its function in progression of cervical cancer (CC) remains unknown. In this study, we found that SO...

journal_title：Cell death & disease

authors： Sun R,Jiang B,Qi H,Zhang X,Yang J,Duan J,Li Y,Li G

更新日期：2015-11-19 00:00:00

abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

journal_title：Cell death & disease

authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

更新日期：2020-10-14 00:00:00

abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

journal_title：Cell death & disease

authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

更新日期：2016-09-22 00:00:00

abstract：:Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...

journal_title：Cell death & disease

authors： Shen X,Xu F,Li M,Wu S,Zhang J,Wang A,Xu L,Liu Y,Zhu G

更新日期：2020-10-22 00:00:00

abstract：:Autophagy is a pivotal intracellular process by which cellular macromolecules are degraded upon various stimuli. A failure in the degradation of autophagic substrates such as impaired organelles and protein aggregates leads to their accumulations, which are characteristics of many neurodegenerative diseases. Pharmacol...

journal_title：Cell death & disease

authors： Yoon YS,Cho ED,Jung Ahn W,Won Lee K,Lee SJ,Lee HJ

更新日期：2017-10-05 00:00:00