POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway.

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

journal_title：Cell death & disease

authors： He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

更新日期：2014-01-16 00:00:00

abstract：:Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axon...

journal_title：Cell death & disease

authors： Catenaccio A,Llavero Hurtado M,Diaz P,Lamont DJ,Wishart TM,Court FA

更新日期：2017-11-09 00:00:00

abstract：:Melatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial...

journal_title：Cell death & disease

authors： Lee SJ,Lee HJ,Jung YH,Kim JS,Choi SH,Han HJ

更新日期：2018-01-19 00:00:00

abstract：:Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how Lon regulates apoptosis through its chaperone activity. Accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria an...

journal_title：Cell death & disease

authors： Sung YJ,Kao TY,Kuo CL,Fan CC,Cheng AN,Fang WC,Chou HY,Lo YK,Chen CH,Jiang SS,Chang IS,Hsu CH,Lee JC,Lee AY

更新日期：2018-06-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...

journal_title：Cell death & disease

authors： Zhang Y,Li D,Jiang Q,Cao S,Sun H,Chai Y,Li X,Ren T,Yang R,Feng F,Li BA,Zhao Q

更新日期：2018-07-03 00:00:00

abstract：:Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to produce 1-methylnicotinamide (MeN). We have previously shown that NNMT expression protected against neurotoxin-mediated cell death by increasing Complex I (CxI) activity, resulting in increased ATP synthesis. This was mediated via prote...

journal_title：Cell death & disease

authors： Thomas MG,Saldanha M,Mistry RJ,Dexter DT,Ramsden DB,Parsons RB

更新日期：2013-06-13 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...

journal_title：Cell death & disease

authors： Kuo CJ,Wang ST,Lin CM,Chiu HC,Huang CR,Lee DY,Chang GD,Chou TC,Chen JW,Chen CS

更新日期：2018-03-07 00:00:00

abstract：:Paracetamol (acetaminophen, APAP) is a universally used analgesic and antipyretic agent. Considered safe at therapeutic doses, overdoses cause acute liver damage characterized by centrilobular hepatic necrosis. One of the major clinical problems of paracetamol-induced liver disease is the development of hemorrhagic al...

journal_title：Cell death & disease

authors： Badmann A,Langsch S,Keogh A,Brunner T,Kaufmann T,Corazza N

更新日期：2012-12-20 00:00:00

abstract：:Elongation factor Tu GTP binding domain containing 2 (EFTUD2), a spliceosomal GTPase, plays a pivotal role in multiple organ development and innate immune. It has been reported that EFTUD2 is a new host factor with activity against HCV infection. However, the role of EFTUD2 in solid tumors, including hepatocellular ca...

journal_title：Cell death & disease

authors： Tu M,He L,You Y,Li J,Yao N,Qu C,Huang W,Xu L,Luo R,Hong J

更新日期：2020-10-06 00:00:00

abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

journal_title：Cell death & disease

authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

更新日期：2016-02-04 00:00:00

abstract：:SOX4, a member of the SOX (sex-determining region Y-related HMG box) transcription factor family, has been reported to be abnormally expressed in a wide variety of cancers, and to exert a pleiotropic function. However, its function in progression of cervical cancer (CC) remains unknown. In this study, we found that SO...

journal_title：Cell death & disease

authors： Sun R,Jiang B,Qi H,Zhang X,Yang J,Duan J,Li Y,Li G

更新日期：2015-11-19 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:Drug resistance is one of the major hurdles for cancer treatment. However, the underlying mechanisms are still largely unknown and therapeutic options remain limited. In this study, we show that microRNA (miR)-587 confers resistance to 5-fluorouracil (5-FU)-induced apoptosis in vitro and reduces the potency of 5-FU in...

journal_title：Cell death & disease

authors： Zhang Y,Talmon G,Wang J

更新日期：2015-08-06 00:00:00

abstract：:Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones. However, over the years, a number of studies pointed ...

journal_title：Cell death & disease

authors： Labi V,Erlacher M

更新日期：2015-03-05 00:00:00

abstract：:Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho GTPase-activating protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed in glioma and pancreatic ductal adenocarcinoma. The present study explored the expression in colorectal cance...

journal_title：Cell death & disease

authors： Pan S,Deng Y,Fu J,Zhang Y,Zhang Z,Ru X,Qin X

更新日期：2018-06-04 00:00:00

abstract：:A proper number of oligodendrocytes in the nerve system is essential for neuronal functions. In the olfactory bulb (OB), enriched oligodendrocytes are crucial for olfactory information processing. However, how the precise number of oligodendrocytes in the OB is regulated remains elusive. Here we identified that the tr...

journal_title：Cell death & disease

authors： Zhang Y,Cai Y,Wang Y,Deng X,Zhao Y,Zhang Y,Xie Y

更新日期：2021-01-18 00:00:00

abstract：:Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...

journal_title：Cell death & disease

authors： Li TT,Jia LX,Zhang WM,Li XY,Zhang J,Li YL,Li HH,Qi YF,Du J

更新日期：2016-06-09 00:00:00

abstract：:Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas an...

journal_title：Cell death & disease

authors： Li C,Liu X,Liu Y,Liu X,Wang R,Liao J,Wu S,Fan J,Peng Z,Li B,Wang Z

更新日期：2018-09-27 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

journal_title：Cell death & disease

authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

更新日期：2013-10-24 00:00:00

abstract：:The emergence of drug resistant tumours that are able to escape cell death pose a major problem in the treatment of cancers. Tumours develop resistance to DNA-damaging chemotherapeutic agents by acquiring the ability to repair their DNA. Combination therapies that induce DNA damage and disrupt the DNA damage repair pr...

journal_title：Cell death & disease

authors： Wansleben S,Davis E,Peres J,Prince S

更新日期：2013-10-10 00:00:00

abstract：:Recent findings demonstrate that aberrant downregulation of the iron-exporter protein, ferroportin (FPN1), is associated with poor prognosis and osteoclast differentiation in multiple myeloma (MM). Here, we show that FPN1 was downregulated in MM and that clustered regularly interspaced short palindromic repeat (CRISPR...

journal_title：Cell death & disease

authors： Kong Y,Hu L,Lu K,Wang Y,Xie Y,Gao L,Yang G,Xie B,He W,Chen G,Wu H,Wu X,Zhan F,Shi J

更新日期：2019-08-19 00:00:00

abstract：:Enhanced Myd88 expression has been found in various parenchymal tumors especially in hepatocellular carcinoma with little mechanism of its upregulation known. A lot of long non-coding RNAs are reported to regulate the protein-coding genes which have location association through various mechanisms. In our study we conf...

journal_title：Cell death & disease

authors： Xu X,Yin Y,Tang J,Xie Y,Han Z,Zhang X,Liu Q,Qin X,Huang X,Sun B

更新日期：2017-10-12 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of glioma...

journal_title：Cell death & disease

authors： Fan Z,Zheng J,Xue Y,Liu X,Wang D,Yang C,Ma J,Liu L,Ruan X,Wang Z,Liu Y

更新日期：2018-12-05 00:00:00

abstract：:Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...

journal_title：Cell death & disease

authors： Ma Y,Yang Q,Zhong Z,Liang W,Zhang L,Yang Y,Ding G

更新日期：2018-02-07 00:00:00

abstract：:The original version of this Article contained an error in Fig. 1, in which a number of incorrect fluorescence images were inadvertently incorporated into the panel. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Cell death & disease

authors： Jones VC,Atkinson-Dell R,Verkhratsky A,Mohamet L

更新日期：2019-03-12 00:00:00

abstract：:The voltage-gated K+ channel has key roles in the vasculature and in atrial excitability and contributes to apoptosis in various tissues. In this study, we have explored its regulation by carbon monoxide (CO), a product of the cytoprotective heme oxygenase enzymes, and a recognized toxin. CO inhibited recombinant Kv1....

journal_title：Cell death & disease

authors： Al-Owais MM,Hettiarachchi NT,Boyle JP,Scragg JL,Elies J,Dallas ML,Lippiat JD,Steele DS,Peers C

更新日期：2017-11-02 00:00:00

abstract：:Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been e...

journal_title：Cell death & disease

authors： Wu C,Li Z,Ding X,Guo X,Sun Y,Wang X,Hu Y,Li T,La X,Li J,Li JA,Li W,Xue L

更新日期：2019-11-26 00:00:00