Ferroportin downregulation promotes cell proliferation by modulating the Nrf2-miR-17-5p axis in multiple myeloma.

abstract：:The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...

journal_title：Cell death & disease

authors： Fearn A,Situmorang GR,Fox C,Oakley F,Howarth R,Wilson CL,Kiosia A,Robson MG,Mann DA,Moles A,Sheerin NS

更新日期：2017-06-15 00:00:00

abstract：:Therapeutic resistance of neoplasms is mainly attributed to gradual evolution of mutational profile1. Here, we demonstrate a microRNA-mediated mechanism that effectively improves fitness of SKBR3 mammary carcinoma cells by cytoplasmic reprogramming. The reprogramming is triggered by endogenous miR4673 transcribed from...

journal_title：Cell death & disease

authors： Dökümcü K,Simonian M,Farahani RM

更新日期：2018-10-19 00:00:00

abstract：:A major hallmark of Parkinson's disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necroptosis is a regulated process of cell death triggered by RIPK1. Although the pathophysiology of PD has been st...

journal_title：Cell death & disease

authors： Hu YB,Zhang YF,Wang H,Ren RJ,Cui HL,Huang WY,Cheng Q,Chen HZ,Wang G

更新日期：2019-08-05 00:00:00

abstract：:Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8+ cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OVA-specific CD8+ CTLs ...

journal_title：Cell death & disease

authors： Wakabayashi A,Shimizu M,Shinya E,Takahashi H

更新日期：2018-05-24 00:00:00

abstract：:It has been recognized that myocardial apoptosis is one major factor in the development of heart dysfunction and autophagy has been shown to influence the apoptosis. In previous studies, we reported that anti-β1-adrenergic receptor autoantibodies (β1-AABs) decreased myocardial autophagy, but the role of decreased auto...

journal_title：Cell death & disease

authors： Wang L,Li Y,Ning N,Wang J,Yan Z,Zhang S,Jiao X,Wang X,Liu H

更新日期：2018-03-14 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:The positive results of the apatinib phase III trial have cast new light on treatment for patients with advanced gastric cancer (GC). However, in terms of safety, apatinib toxicities may lead to a dose modification or treatment interruption. Therefore, proper intervention is urgently needed to help patients benefit fr...

journal_title：Cell death & disease

authors： Ma L,Wang Z,Xie M,Quan Y,Zhu W,Yang F,Zhao C,Fan Y,Fang N,Jiang H,Wang Q,Wang S,Zhou J,Chen X,Shu Y

更新日期：2020-03-05 00:00:00

abstract：:Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) protei...

journal_title：Cell death & disease

authors： Yang C,Hu Y,Zhou B,Bao Y,Li Z,Gong C,Yang H,Wang S,Xiao Y

更新日期：2020-11-08 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

journal_title：Cell death & disease

authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

更新日期：2020-08-21 00:00:00

abstract：:We have recently found that primary rat embryonic fibroblasts (REFs) could be immortalized by overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2). A derived cell line, designated 18IM, expressed the embryonic stem cell markers SSEA-1 and Sox2. Upon inoculation into severe combined immunodefici...

journal_title：Cell death & disease

authors： Yenamandra SP,Darekar SD,Kashuba V,Matskova L,Klein G,Kashuba E

更新日期：2012-01-19 00:00:00

abstract：:Aggregatibacter (Actinobacillus) actinomycetemcomitans is a facultative anaerobic gram-negative bacterium associated with severe forms of periodontitis. A leukotoxin, which belongs to the repeats-in-toxin family, is believed to be one of its virulence factors and to have an important role in the bacterium's pathogenic...

journal_title：Cell death & disease

authors： Kelk P,Abd H,Claesson R,Sandström G,Sjöstedt A,Johansson A

更新日期：2011-03-10 00:00:00

abstract：:Chemotherapy is a standard treatment for non-small-cell lung cancer (NSCLC). However, the dose-limiting toxicity of drugs and the development of chemoresistance are major clinical challenges to successful management of NSCLC. Asian traditional medicine is gaining global attention as a non-toxic alternative to chemothe...

journal_title：Cell death & disease

authors： Kwon T,Chandimali N,Huynh DL,Zhang JJ,Kim N,Bak Y,Yoon DY,Yu DY,Lee JC,Gera M,Ghosh M,Park YH,Jeong DK

更新日期：2018-02-14 00:00:00

abstract：:HFM1 (helicase for meiosis 1) is widely recognized as an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. HFM1 is a candidate gene of premature ovarian failure (POF), hence it is also known as POF9. However, the roles of HFM1 in mammalian oocytes remain uncertain. To investigate the functions of ...

journal_title：Cell death & disease

authors： Wang H,Zhong C,Yang R,Yin Y,Tan R,Gao L,Gao C,Cui Y,Pu D,Wu J

更新日期：2020-06-30 00:00:00

abstract：:We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and dist...

journal_title：Cell death & disease

authors： Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ

更新日期：2015-10-15 00:00:00

abstract：:Breast cancer is the worldwide leading cause of cancer mortality in women. The majority of deaths from breast cancer arise from metastasis of local tumors. Cancer cells support their rapid proliferation by diverting metabolites into anabolic pathways, but during cancer metastasis, the proliferative program of invasive...

journal_title：Cell death & disease

authors： Lou C,Xiao M,Cheng S,Lu X,Jia S,Ren Y,Li Z

更新日期：2016-03-24 00:00:00

abstract：:The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets remain unknown. In this...

journal_title：Cell death & disease

authors： Polier G,Ding J,Konkimalla BV,Eick D,Ribeiro N,Köhler R,Giaisi M,Efferth T,Desaubry L,Krammer PH,Li-Weber M

更新日期：2011-07-21 00:00:00

abstract：:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...

journal_title：Cell death & disease

authors： Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJ

更新日期：2015-05-07 00:00:00

abstract：:Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

journal_title：Cell death & disease

authors： He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

更新日期：2014-01-16 00:00:00

abstract：:The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

journal_title：Cell death & disease

authors： Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

更新日期：2013-12-05 00:00:00

abstract：:Gastric cancer (GC) is one of the most frequent malignancies, and increasing evidence supports the contribution of microRNA (miRNAs) to cancer progression. miR-1254 has been confirmed to participate in the regulation of various cancers, while the function of miR-1254 in GC remains unknown. In this study, we investigat...

journal_title：Cell death & disease

authors： Jiang M,Shi L,Yang C,Ge Y,Lin L,Fan H,He Y,Zhang D,Miao Y,Yang L

更新日期：2019-01-10 00:00:00

abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

journal_title：Cell death & disease

authors： Gao Y,Ge W

更新日期：2018-01-18 00:00:00

abstract：:Hepatocyte transplantation as a substitute strategy of orthotopic liver transplantation is being studied for treating end-stage liver diseases. Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocyte...

journal_title：Cell death & disease

authors： Xiang D,Liu CC,Wang MJ,Li JX,Chen F,Yao H,Yu B,Lu L,Borjigin U,Chen YX,Zhong L,Wangensteen KJ,He ZY,Wang X,Hu YP

更新日期：2014-05-22 00:00:00

abstract：:DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the molecular and cellular functions of this transmembrane protein remain poorly understood. Previously, we have propo...

journal_title：Cell death & disease

authors： Zhang R,Varela M,Forn-Cuní G,Torraca V,van der Vaart M,Meijer AH

更新日期：2020-04-24 00:00:00

abstract：:Epithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial role in endometrial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63α is associated with fibrosis process and epithelial dysfunction in endometria of patients with intrauterine a...

journal_title：Cell death & disease

authors： Zhao G,Li R,Cao Y,Song M,Jiang P,Wu Q,Zhou Z,Zhu H,Wang H,Dai C,Liu D,Yao S,Lv H,Wang L,Dai J,Zhou Y,Hu Y

更新日期：2020-06-11 00:00:00

abstract：:Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown. Here we systematically screened for potent PAC-1 targets using 29 enhanced green fluorescent protein-labeled reporter cell lines and identified hypoxia-inducib...

journal_title：Cell death & disease

authors： Li F,Wei A,Bu L,Long L,Chen W,Wang C,Zhao C,Wang L

更新日期：2018-10-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest and apoptosis in hum...

journal_title：Cell death & disease

authors： Liao YJ,Bai HY,Li ZH,Zou J,Chen JW,Zheng F,Zhang JX,Mai SJ,Zeng MS,Sun HD,Pu JX,Xie D

更新日期：2014-03-20 00:00:00

abstract：:A cell-in-cell process refers to the invasion of one living cell into another homotypic or heterotypic cell. Different from non-apoptotic death processes of internalized cells termed entosis or cannibalism, we previously reported an apoptotic cell-in-cell death occurring during heterotypic cell-in-cell formation. In t...

journal_title：Cell death & disease

authors： Wang S,He MF,Chen YH,Wang MY,Yu XM,Bai J,Zhu HY,Wang YY,Zhao H,Mei Q,Nie J,Ma J,Wang JF,Wen Q,Ma L,Wang Y,Wang XN

更新日期：2013-10-10 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has the highest incidence of cancer-related death worldwide and a high medical need for more effective therapies. Small-molecule inhibitors of the bromodomain and extra terminal domain (BET) family such as JQ1, I-BET762 and OTX-015 are active in a wide range of different cancer types...

journal_title：Cell death & disease

authors： Klingbeil O,Lesche R,Gelato KA,Haendler B,Lejeune P

更新日期：2016-09-08 00:00:00

abstract：:Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recen...

journal_title：Cell death & disease

authors： Xu Y,Ge Z,Zhang E,Zuo Q,Huang S,Yang N,Wu D,Zhang Y,Chen Y,Xu H,Huang H,Jiang Z,Sun L

更新日期：2017-10-12 00:00:00