Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.

abstract：:Granzyme B (GZMB) is a proapoptotic serine protease that is released by cytotoxic lymphocytes. However, GZMB can also be produced by other cell types and is capable of cleaving extracellular matrix (ECM) proteins. GZMB contributes to abdominal aortic aneurysm (AAA) through an extracellular, perforin-independent mechan...

journal_title：Cell death & disease

authors： Ang LS,Boivin WA,Williams SJ,Zhao H,Abraham T,Carmine-Simmen K,McManus BM,Bleackley RC,Granville DJ

更新日期：2011-09-08 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, we show that the spe...

journal_title：Cell death & disease

authors： Schüll S,Günther SD,Brodesser S,Seeger JM,Tosetti B,Wiegmann K,Pongratz C,Diaz F,Witt A,Andree M,Brinkmann K,Krönke M,Wiesner RJ,Kashkar H

更新日期：2015-03-12 00:00:00

abstract：:Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 and mannose-6-phosphate (M6P)-tagged...

journal_title：Cell death & disease

authors： Takeda T,Komatsu M,Chiwaki F,Komatsuzaki R,Nakamura K,Tsuji K,Kobayashi Y,Tominaga E,Ono M,Banno K,Aoki D,Sasaki H

更新日期：2019-11-20 00:00:00

abstract：:The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of apoptogenic factors such as cytochrome-c, which promote activation of the caspase cascade and cellular demolit...

journal_title：Cell death & disease

authors： Ke F,Bouillet P,Kaufmann T,Strasser A,Kerr J,Voss AK

更新日期：2013-06-06 00:00:00

abstract：:Chemotherapy is a standard treatment for non-small-cell lung cancer (NSCLC). However, the dose-limiting toxicity of drugs and the development of chemoresistance are major clinical challenges to successful management of NSCLC. Asian traditional medicine is gaining global attention as a non-toxic alternative to chemothe...

journal_title：Cell death & disease

authors： Kwon T,Chandimali N,Huynh DL,Zhang JJ,Kim N,Bak Y,Yoon DY,Yu DY,Lee JC,Gera M,Ghosh M,Park YH,Jeong DK

更新日期：2018-02-14 00:00:00

abstract：:Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergize...

journal_title：Cell death & disease

authors： Su Z,Yang R,Zhang W,Xu L,Zhong Y,Yin Y,Cen J,DeWitt JP,Wei Q

更新日期：2015-05-07 00:00:00

abstract：:In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamyci...

journal_title：Cell death & disease

authors： Blagosklonny MV

更新日期：2014-12-04 00:00:00

abstract：:Aberrantly expressed miRNAs play a crucial role in the development of multiple cancer types, including chordoma. However, the detailed molecular mechanisms are unclear and need to be elucidated. In this study, miRNAs were screened by miRNA array analysis and then confirmed by real-time PCR analysis. We found that miR-...

journal_title：Cell death & disease

authors： Zhang H,Yang K,Ren T,Huang Y,Tang X,Guo W

更新日期：2018-06-07 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Proinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase tumor progression l...

journal_title：Cell death & disease

authors： Varin EM,Wojtusciszyn A,Broca C,Muller D,Ravier MA,Ceppo F,Renard E,Tanti JF,Dalle S

更新日期：2016-01-21 00:00:00

abstract：:Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes l...

journal_title：Cell death & disease

authors： Huang X,Xiao S,Zhu X,Yu Y,Cao M,Zhang X,Li S,Zhu W,Wu F,Zheng X,Jin L,Xie C,Huang X,Zou P,Li X,Cui R

更新日期：2020-09-22 00:00:00

abstract：:BMP2 expression is spatiotemporally correlated with embryo implantation and is crucial for endometrial decidualization and fertility in mice. BMP2 has been reported to increase the mesenchymal adhesion molecule N-cadherin and enhance cell invasion in cancer cells; moreover, studies suggest that N-cadherin promotes pla...

journal_title：Cell death & disease

authors： Zhao HJ,Klausen C,Li Y,Zhu H,Wang YL,Leung PCK

更新日期：2018-02-07 00:00:00

abstract：:MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Here, by us...

journal_title：Cell death & disease

authors： Iosue I,Quaranta R,Masciarelli S,Fontemaggi G,Batassa EM,Bertolami C,Ottone T,Divona M,Salvatori B,Padula F,Fatica A,Lo-Coco F,Nervi C,Fazi F

更新日期：2013-11-21 00:00:00

abstract：:A cell-in-cell process refers to the invasion of one living cell into another homotypic or heterotypic cell. Different from non-apoptotic death processes of internalized cells termed entosis or cannibalism, we previously reported an apoptotic cell-in-cell death occurring during heterotypic cell-in-cell formation. In t...

journal_title：Cell death & disease

authors： Wang S,He MF,Chen YH,Wang MY,Yu XM,Bai J,Zhu HY,Wang YY,Zhao H,Mei Q,Nie J,Ma J,Wang JF,Wen Q,Ma L,Wang Y,Wang XN

更新日期：2013-10-10 00:00:00

abstract：:The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion o...

journal_title：Cell death & disease

authors： Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J

更新日期：2018-02-14 00:00:00

abstract：:Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer cells ECA109 and Kyse150. We then found that Wnt signaling activity was higher in radioresistant cel...

journal_title：Cell death & disease

authors： Zhao Y,Yi J,Tao L,Huang G,Chu X,Song H,Chen L

更新日期：2018-04-01 00:00:00

abstract：:The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

journal_title：Cell death & disease

authors： Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

更新日期：2020-03-18 00:00:00

abstract：:The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...

journal_title：Cell death & disease

authors： Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

更新日期：2018-07-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Sun S,Zhang Y,Zheng J,Duan B,Cui J,Chen Y,Deng W,Ye B,Liu L,Chen Y,Du J,Gu L

更新日期：2019-08-22 00:00:00

abstract：:Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...

journal_title：Cell death & disease

authors： Wassermann-Dozorets R,Rubinstein M

更新日期：2017-04-06 00:00:00

abstract：:Cell migration plays pivotal roles in many biological processes; however, its underlying mechanism remains unclear. Here, we find that NudC-like protein 2 (NudCL2), a cochaperone of heat shock protein 90 (Hsp90), modulates cell migration by stabilizing both myosin-9 and lissencephaly protein 1 (LIS1). Either knockdown...

journal_title：Cell death & disease

authors： Chen W,Wang W,Sun X,Xie S,Xu X,Liu M,Yang C,Li M,Zhang W,Liu W,Wang L,Zhou T,Yang Y

更新日期：2020-07-14 00:00:00

abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

journal_title：Cell death & disease

authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

更新日期：2020-10-14 00:00:00

abstract：:Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and acquired resistance remain a ...

journal_title：Cell death & disease

authors： Eyermann CE,Haley JD,Alexandrova EM

更新日期：2021-01-26 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1α and HIF-2α, emerging evidence suggests differences between both molecules in terms of transcriptiona...

journal_title：Cell death & disease

authors： Zhao J,Du F,Shen G,Zheng F,Xu B

更新日期：2015-01-15 00:00:00

abstract：:The glutamate-induced excitotoxicity pathway has been reported in several neurodegenerative diseases. Molecules that inhibit the release of glutamate or cause the overactivation of glutamate receptors can minimize neuronal cell death in these diseases. Osmotin, a homolog of mammalian adiponectin, is a plant protein fr...

journal_title：Cell death & disease

authors： Shah SA,Lee HY,Bressan RA,Yun DJ,Kim MO

更新日期：2014-01-30 00:00:00

abstract：:Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant soluble TNF-related apoptosis inducing ligand (TRAIL) necessitate novel reagents with improved apoptotic activity/tumor selectivity. Apoptosis induction by a single-c...

journal_title：Cell death & disease

authors： Siegemund M,Pollak N,Seifert O,Wahl K,Hanak K,Vogel A,Nussler AK,Göttsch D,Münkel S,Bantel H,Kontermann RE,Pfizenmaier K

更新日期：2012-04-12 00:00:00

abstract：:Protein-coding genes account for only ~2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs). A growing volume of literature has proposed that lncRNAs are important factors in cancer. Colon cancer-associated transcript-1 (CCAT1), an lncRNA, which ...

journal_title：Cell death & disease

authors： Ma MZ,Chu BF,Zhang Y,Weng MZ,Qin YY,Gong W,Quan ZW

更新日期：2015-01-08 00:00:00

abstract：:The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...

journal_title：Cell death & disease

authors： Yao M,Shi X,Li Y,Xiao Y,Butler W,Huang Y,Du L,Wu T,Bian X,Shi G,Ye D,Fu G,Wang J,Ren S

更新日期：2020-08-15 00:00:00