Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity.

abstract：:p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (transactivation domain (TA)p63 and amino terminal truncated protein(ΔN)...

journal_title：Cell death & disease

authors： Celardo I,Grespi F,Antonov A,Bernassola F,Garabadgiu AV,Melino G,Amelio I

更新日期：2013-05-23 00:00:00

abstract：:Cytokinesis is the last step of cell division and is concluded by the abscission of the intercellular bridge that connects two daughter cells. The tight regulation of cytokinesis completion is essential because cytokinesis failure is associated with various human diseases. Here, we report that iASPP, a member of the a...

journal_title：Cell death & disease

authors： Gao K,Zhang Y,Shi Q,Zhang J,Zhang L,Sun H,Jiao D,Zhao X,Tao H,Wei Y,Wang Y,Saiyin H,Zhao SM,Li Y,Zhang P,Wang C

更新日期：2018-05-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor survival. It is urgent to search for new efficient drugs with good stability and safety for clinical therapy. This study aims to identify potential anticancer drugs from a compound library consisting of 429 natural products....

journal_title：Cell death & disease

authors： Hong P,Liu QW,Xie Y,Zhang QH,Liao L,He QY,Li B,Xu WW

更新日期：2020-07-13 00:00:00

abstract：:MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Here, by us...

journal_title：Cell death & disease

authors： Iosue I,Quaranta R,Masciarelli S,Fontemaggi G,Batassa EM,Bertolami C,Ottone T,Divona M,Salvatori B,Padula F,Fatica A,Lo-Coco F,Nervi C,Fazi F

更新日期：2013-11-21 00:00:00

abstract：:Soluble Axl (sAxl) was recently shown to be strongly released into the blood during liver fibrogenesis and hepatocellular carcinoma suggesting sAxl as a biomarker of liver diseases. In this study we are the first to evaluate sAxl in human serum in comparison to Enhanced Liver Fibrosis (ELF) test and transient elastogr...

journal_title：Cell death & disease

authors： Staufer K,Dengler M,Huber H,Marculescu R,Stauber R,Lackner C,Dienes HP,Kivaranovic D,Schachner C,Zeitlinger M,Wulkersdorfer B,Rauch P,Prager G,Trauner M,Mikulits W

更新日期：2017-10-26 00:00:00

abstract：:Hypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause of heart failure and mortality. Our previous studies found that heat shock factor 1 (HSF1) protected cardiomyo...

journal_title：Cell death & disease

authors： Huang CY,Pai PY,Kuo CH,Ho TJ,Lin JY,Lin DY,Tsai FJ,Padma VV,Kuo WW,Huang CY

更新日期：2017-08-10 00:00:00

abstract：:Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to release and cell dea...

journal_title：Cell death & disease

authors： Hänggi K,Vasilikos L,Valls AF,Yerbes R,Knop J,Spilgies LM,Rieck K,Misra T,Bertin J,Gough PJ,Schmidt T,de Almodòvar CR,Wong WW

更新日期：2017-02-02 00:00:00

abstract：:The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells. The serine/threonine kinase casein kinase 2 (CK2) has a well-reported role in prostate cancer resistance to apoptotic agents or anticancer drugs. However, the mechanistic understanding on how CK2 suppo...

journal_title：Cell death & disease

authors： de Thonel A,Hazoumé A,Kochin V,Isoniemi K,Jego G,Fourmaux E,Hammann A,Mjahed H,Filhol O,Micheau O,Rocchi P,Mezger V,Eriksson JE,Rangnekar VM,Garrido C

更新日期：2014-01-23 00:00:00

abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

journal_title：Cell death & disease

authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

更新日期：2018-09-26 00:00:00

abstract：:Although increasing evidence indicated that deregulation of microRNAs (miRNAs) contributed to tumor initiation and progression, but little is known about the biological role of miR-340 in ovarian cancer (OC). In this study, we found that miR-340 expression was downregulated in OC tissues compared with its expression i...

journal_title：Cell death & disease

authors： Huang Z,Li Q,Luo K,Zhang Q,Geng J,Zhou X,Xu Y,Qian M,Zhang JA,Ji L,Wu J

更新日期：2019-05-08 00:00:00

abstract：:The voltage-gated K+ channel has key roles in the vasculature and in atrial excitability and contributes to apoptosis in various tissues. In this study, we have explored its regulation by carbon monoxide (CO), a product of the cytoprotective heme oxygenase enzymes, and a recognized toxin. CO inhibited recombinant Kv1....

journal_title：Cell death & disease

authors： Al-Owais MM,Hettiarachchi NT,Boyle JP,Scragg JL,Elies J,Dallas ML,Lippiat JD,Steele DS,Peers C

更新日期：2017-11-02 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:Calcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF) is a promising neuroprotective protein for photoreceptor cells but the mechanisms mediating its effects against retinal degeneration are still not well characterized. We addressed this question in the rd1 degenerating mo...

journal_title：Cell death & disease

authors： Comitato A,Subramanian P,Turchiano G,Montanari M,Becerra SP,Marigo V

更新日期：2018-05-01 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Primary cells respond to irradiation by activation of the DNA damage response and cell cycle arrest, which eventually leads to senescence or apoptosis. It is not clear in detail which signaling pathways or networks regulate the induction of either apoptosis or senescence. Primary human fibroblasts are able to withstan...

journal_title：Cell death & disease

authors： Bluwstein A,Kumar N,Léger K,Traenkle J,Oostrum Jv,Rehrauer H,Baudis M,Hottiger MO

更新日期：2013-02-14 00:00:00

abstract：:The WWOX tumor suppressor is a WW domain-containing protein. Its function in the cell has been shown to be mediated, in part, by interacting with its partners through its first WW (WW1) domain. Here, we demonstrated that WWOX via WW1 domain interacts with p53 homolog, ΔNp63α. This protein-protein interaction stabilize...

journal_title：Cell death & disease

authors： Salah Z,Bar-mag T,Kohn Y,Pichiorri F,Palumbo T,Melino G,Aqeilan RI

更新日期：2013-01-31 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the m...

journal_title：Cell death & disease

authors： Zhu S,Zhang J,Xu F,Xu E,Ruan W,Ma Y,Huang Q,Lai M

更新日期：2015-03-19 00:00:00

abstract：:Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations. Patients with Costello syndrome present craniofacial abnormalities, cardiac defects, and cancer predisposition, as well as skin abnormalities, including papillomas, keratosis pilaris, and eczematous dermatitis. However, the ...

journal_title：Cell death & disease

authors： Katata Y,Inoue SI,Asao A,Kobayashi S,Terui H,Inoue-Shibui A,Abe T,Niihori T,Aiba S,Ishii N,Kure S,Aoki Y

更新日期：2020-08-13 00:00:00

abstract：:Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening diseases that are associated with high mortality rates due to treatment limitations. Neutrophils play key roles in the pathogenesis of ALI/ARDS by promoting the inflammation and injury of the alveolar mic...

journal_title：Cell death & disease

authors： Zhang Y,Liu H,Yao J,Huang Y,Qin S,Sun Z,Xu Y,Wan S,Cheng H,Li C,Zhang X,Ke Y

更新日期：2016-11-10 00:00:00

abstract：:Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for the initiation of ...

journal_title：Cell death & disease

authors： Athwal T,Huang W,Mukherjee R,Latawiec D,Chvanov M,Clarke R,Smith K,Campbell F,Merriman C,Criddle D,Sutton R,Neoptolemos J,Vlatković N

更新日期：2014-04-10 00:00:00

abstract：:Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite cells (SSCs) drive skeletal muscle regeneration. Increased autophagy can reduce the proliferative capacity of SS...

journal_title：Cell death & disease

authors： Song KY,Guo XM,Wang HQ,Zhang L,Huang SY,Huo YC,Zhang G,Feng JZ,Zhang RR,Ma Y,Hu QZ,Qin XY

更新日期：2020-07-18 00:00:00

abstract：:Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of glioma...

journal_title：Cell death & disease

authors： Fan Z,Zheng J,Xue Y,Liu X,Wang D,Yang C,Ma J,Liu L,Ruan X,Wang Z,Liu Y

更新日期：2018-12-05 00:00:00

abstract：:Although it is becoming increasingly evident that maternal starvation during pregnancy can have permanent effects on a range of physiological processes in the offspring, scant information is available about the consequence of such condition for oogenesis and hence for lifetime reproductive success of progeny in mammal...

journal_title：Cell death & disease

authors： Wang JJ,Yu XW,Wu RY,Sun XF,Cheng SF,Ge W,Liu JC,Li YP,Liu J,Zou SH,De Felici M,Shen W

更新日期：2018-05-01 00:00:00

abstract：:Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems. As Hipk2(-/-) mice show behavioral abnormalities consistent with cerebellar dysfunction, we investigated...

journal_title：Cell death & disease

authors： Anzilotti S,Tornincasa M,Gerlini R,Conte A,Brancaccio P,Cuomo O,Bianco G,Fusco A,Annunziato L,Pignataro G,Pierantoni GM

更新日期：2015-12-03 00:00:00

abstract：:Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...

journal_title：Cell death & disease

authors： Mao YX,Cai WJ,Sun XY,Dai PP,Li XM,Wang Q,Huang XL,He B,Wang PP,Wu G,Ma JF,Huang SB

更新日期：2018-06-04 00:00:00

abstract：:Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has ...

journal_title：Cell death & disease

authors： Vasileva EA,Shuvalov OU,Garabadgiu AV,Melino G,Barlev NA

更新日期：2015-07-23 00:00:00

abstract：:The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence of KIFC1, cell cycle kinetics decrease significa...

journal_title：Cell death & disease

authors： Wei YL,Yang WX

更新日期：2019-05-24 00:00:00

abstract：:The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

journal_title：Cell death & disease

authors： Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

更新日期：2020-03-18 00:00:00

abstract：:STAT1, which carries tumor suppressor functions in several models, consists of two isoforms, namely STAT1α and STAT1β. The biological function and significance of STAT1β has never been examined in human cancer. We examined STAT1β function in esophageal squamous cell carcinoma (ESCC) by transfecting a STAT1β gene into ...

journal_title：Cell death & disease

authors： Zhang Y,Chen Y,Yun H,Liu Z,Su M,Lai R

更新日期：2017-10-05 00:00:00

abstract：:The incidence of malignant melanoma has continued to rise during the past decades. However, in the last few years, treatment protocols have significantly been improved thanks to a better understanding of the key oncogenes and signaling pathways involved in its pathogenesis and progression. Anticancer therapy would eit...

journal_title：Cell death & disease

authors： Mattia G,Puglisi R,Ascione B,Malorni W,Carè A,Matarrese P

更新日期：2018-01-25 00:00:00