HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

abstract：:Despite successful antiretroviral drug therapy, a subset of human immunodeficiency virus-1 (HIV)-positive individuals still display synaptodendritic simplifications and functional cognitive impairments referred to as HIV-associated neurocognitive disorders (HANDs). The neurological damage observed in HAND subjects can...

journal_title：Cell death & disease

authors： Wenzel ED,Speidell A,Flowers SA,Wu C,Avdoshina V,Mocchetti I

更新日期：2019-09-12 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targeted therapies for pat...

journal_title：Cell death & disease

authors： Dielschneider RF,Xiao W,Yoon JY,Noh E,Banerji V,Li H,Marshall AJ,Johnston JB,Gibson SB

更新日期：2014-10-02 00:00:00

abstract：:Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes l...

journal_title：Cell death & disease

authors： Huang X,Xiao S,Zhu X,Yu Y,Cao M,Zhang X,Li S,Zhu W,Wu F,Zheng X,Jin L,Xie C,Huang X,Zou P,Li X,Cui R

更新日期：2020-09-22 00:00:00

abstract：:The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly. LAMR is important for cell viability; however, it is unclear which of its functions are essential. We developed a silent mutant...

journal_title：Cell death & disease

authors： Scheiman J,Jamieson KV,Ziello J,Tseng JC,Meruelo D

更新日期：2010-01-01 00:00:00

abstract：:Growing evidence indicates that cell adhesion to extracellular matrix (ECM) plays an important role in cancer chemoresistance. Leukemic T cells express several adhesion receptors of the β1 integrin subfamily with which they interact with ECM. However, the role of β1 integrins in chemoresistance of T-cell acute lymphob...

journal_title：Cell death & disease

authors： Berrazouane S,Boisvert M,Salti S,Mourad W,Al-Daccak R,Barabé F,Aoudjit F

更新日期：2019-05-01 00:00:00

abstract：:The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was pos...

journal_title：Cell death & disease

authors： Yu Y,Zhao D,Li K,Cai Y,Xu P,Li R,Li J,Chen X,Chen P,Cui G

更新日期：2020-04-24 00:00:00

abstract：:Urethral hypoplasia, including failure of urethral tube closure, is one of the common phenotypes observed in hereditary human disorders, the mechanism of which remains unclear. The present study was thus designed to study the expression, functions, and related mechanisms of the LIM homeobox transcription factor Isl1 t...

journal_title：Cell death & disease

authors： Su T,Liu H,Zhang D,Xu G,Liu J,Evans SM,Pan J,Cui S

更新日期：2019-09-26 00:00:00

abstract：:Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits ...

journal_title：Cell death & disease

authors： Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

更新日期：2020-08-12 00:00:00

abstract：:Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...

journal_title：Cell death & disease

authors： Cheteh EH,Augsten M,Rundqvist H,Bianchi J,Sarne V,Egevad L,Bykov VJ,Östman A,Wiman KG

更新日期：2017-06-01 00:00:00

abstract：:Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+...

journal_title：Cell death & disease

authors： Ousingsawat J,Wanitchakool P,Schreiber R,Kunzelmann K

更新日期：2018-02-20 00:00:00

abstract：:Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty acid (n-3 PUFA), which is largely contained in fish or fish oil, has been reported to promote cell viab...

journal_title：Cell death & disease

authors： Gao B,Han YH,Wang L,Lin YJ,Sun Z,Lu WG,Hu YQ,Li JQ,Lin XS,Liu BH,Jie Q,Yang L,Luo ZJ

更新日期：2016-05-26 00:00:00

abstract：:miRNA let-7e is involved in stem cell differentiation, and metalloproteinases are among its potential target genes. We hypothesized that the inhibitory action of let-7e on regulation of MMP9 expression could represent a crucial mechanism during differentiation of adipose-derived stem cells (ASCs). ASCs were differenti...

journal_title：Cell death & disease

authors： Ventayol M,Viñas JL,Sola A,Jung M,Brüne B,Pi F,Mastora C,Hotter G

更新日期：2014-02-06 00:00:00

abstract：:The glutamate-induced excitotoxicity pathway has been reported in several neurodegenerative diseases. Molecules that inhibit the release of glutamate or cause the overactivation of glutamate receptors can minimize neuronal cell death in these diseases. Osmotin, a homolog of mammalian adiponectin, is a plant protein fr...

journal_title：Cell death & disease

authors： Shah SA,Lee HY,Bressan RA,Yun DJ,Kim MO

更新日期：2014-01-30 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00

abstract：:Melatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial...

journal_title：Cell death & disease

authors： Lee SJ,Lee HJ,Jung YH,Kim JS,Choi SH,Han HJ

更新日期：2018-01-19 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the m...

journal_title：Cell death & disease

authors： Zhu S,Zhang J,Xu F,Xu E,Ruan W,Ma Y,Huang Q,Lai M

更新日期：2015-03-19 00:00:00

abstract：:A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell...

journal_title：Cell death & disease

authors： Angioni R,Sánchez-Rodríguez R,Munari F,Bertoldi N,Arcidiacono D,Cavinato S,Marturano D,Zaramella A,Realdon S,Cattelan A,Viola A,Molon B

更新日期：2020-11-06 00:00:00

abstract：:MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our st...

journal_title：Cell death & disease

authors： Chen X,Zeng K,Xu M,Liu X,Hu X,Xu T,He B,Pan Y,Sun H,Wang S

更新日期：2019-02-12 00:00:00

abstract：:Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...

journal_title：Cell death & disease

authors： Javaheri T,Kazemi Z,Pencik J,Pham HT,Kauer M,Noorizadeh R,Sax B,Nivarthi H,Schlederer M,Maurer B,Hofbauer M,Aryee DN,Wiedner M,Tomazou EM,Logan M,Hartmann C,Tuckermann JP,Kenner L,Mikula M,Dolznig H,Üren A,Richt

更新日期：2016-10-13 00:00:00

abstract：:Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation o...

journal_title：Cell death & disease

authors： Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

更新日期：2020-04-16 00:00:00

abstract：:Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or ...

journal_title：Cell death & disease

authors： Chen H,Zhang H,Zheng Y,Min X,Luo Y,Zhou W,Ma F,Li J,Lu Q,Zhang C,Cai H,Sha W

更新日期：2020-03-16 00:00:00

abstract：:We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and dist...

journal_title：Cell death & disease

authors： Tsenkina Y,Ricard J,Runko E,Quiala-Acosta MM,Mier J,Liebl DJ

更新日期：2015-10-15 00:00:00

abstract：:Monoglyceride lipase (MGL) is a recently discovered cancer-related protein. The role of MGL in tumorigenesis remains to be fully elucidated. We have previously shown that MGL expression was reduced or absent in multiple human malignancies, and overexpression of MGL inhibited cancer cell growth. Here, we have generated...

journal_title：Cell death & disease

authors： Liu R,Wang X,Curtiss C,Landas S,Rong R,Sheikh MS,Huang Y

更新日期：2018-01-18 00:00:00

abstract：:Hepatic myofibroblasts, activated hepatic stellate cells (HSCs), are the main cell type of extracellular matrix (ECM) deposition during hepatic fibrosis. Aberrant DNA methylation-regulated HSCs activation in liver fibrogenesis has been reported, but the functional roles and mechanisms of DNA methylation in hepatic fib...

journal_title：Cell death & disease

authors： Chen X,Li WX,Chen Y,Li XF,Li HD,Huang HM,Bu FT,Pan XY,Yang Y,Huang C,Meng XM,Li J

更新日期：2018-10-03 00:00:00

abstract：:As a common female malignancy, triple-negative breast cancer (TNBC) is the most serious subtype in breast cancer (BC). BAALC binder of MAP3K1 and KLF4 (BAALC) is a common oncogene in acute myelocytic leukemia (AML). We sought to explore the role of BAALC in TNBC. In this study, BAALC was significantly upregulated in T...

journal_title：Cell death & disease

authors： Li S,Wu D,Jia H,Zhang Z

更新日期：2020-08-18 00:00:00

abstract：:Estrogen receptor-alpha positive (ER(+)) breast cancers comprise the majority of human breast cancers, but molecular mechanisms underlying this subtype of breast cancers remain poorly understood. Here, we show that ER(+) mammary luminal tumors arising in Tip30(-/-)MMTV-Neu mice exhibited increased enrichment of lumina...

journal_title：Cell death & disease

authors： Chen F,Li A,Gao S,Hollern D,Williams M,Liu F,VanSickle EA,Andrechek E,Zhang C,Yang C,Luo R,Xiao H

更新日期：2014-05-22 00:00:00

abstract：:Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improv...

journal_title：Cell death & disease

authors： Yadav SK,Kambis TN,Kar S,Park SY,Mishra PK

更新日期：2020-03-13 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN) regulates apoptosis and axonal growth in the developing and adult central nervous system (CNS). Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, highlighted by the find...

journal_title：Cell death & disease

authors： Shabanzadeh AP,D'Onofrio PM,Magharious M,Choi KAB,Monnier PP,Koeberle PD

更新日期：2019-07-29 00:00:00

abstract：:The growing number of studies suggested that inhibition of autophagy enhances the efficacy of Akt kinase inhibitors in cancer therapy. Here, we provide evidence that ML-9, a widely used inhibitor of Akt kinase, myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1), represents the 'two-in-one' com...

journal_title：Cell death & disease

authors： Kondratskyi A,Yassine M,Slomianny C,Kondratska K,Gordienko D,Dewailly E,Lehen'kyi V,Skryma R,Prevarskaya N

更新日期：2014-04-24 00:00:00

abstract：:High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated...

journal_title：Cell death & disease

authors： Peng Y,Yang C,Shi X,Li L,Dong H,Liu C,Fang Z,Wang Z,Ming S,Liu M,Xie B,Gao X,Sun Y

更新日期：2019-01-15 00:00:00