HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling.

abstract：:The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metabolism proteins, inclu...

journal_title：Cell death & disease

authors： Zhao P,Qian C,Chen YJ,Sheng Y,Ke Y,Qian ZM

更新日期：2019-09-24 00:00:00

abstract：:The role of autophagy in cancer onset and progression appears still controversial. On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. In addition, autophagy interpheres with cell cycle pr...

journal_title：Cell death & disease

authors： Buccarelli M,Marconi M,Pacioni S,De Pascalis I,D'Alessandris QG,Martini M,Ascione B,Malorni W,Larocca LM,Pallini R,Ricci-Vitiani L,Matarrese P

更新日期：2018-08-06 00:00:00

abstract：:Reactive oxygen species (ROS) accumulation are involved in noise- and ototoxic drug-induced hair cell loss, which is the major cause of hearing loss. Bmi1 is a member of the Polycomb protein family and has been reported to regulate mitochondrial function and ROS level in thymocytes and neurons. In this study, we repor...

journal_title：Cell death & disease

authors： Chen Y,Li L,Ni W,Zhang Y,Sun S,Miao D,Chai R,Li H

更新日期：2015-01-22 00:00:00

abstract：:Tumor metastasis leads to high mortality; therefore, understanding the mechanisms that underlie tumor metastasis is crucial. Generally seen as a secretory protein, osteopontin (OPN) is involved in multifarious pathophysiological events. Here, we present a novel pro-metastatic role of OPN during metastatic colonization...

journal_title：Cell death & disease

authors： Jia R,Liang Y,Chen R,Liu G,Wang H,Tang M,Zhou X,Wang H,Yang Y,Wei H,Li B,Song Y,Zhao J

更新日期：2016-12-29 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00

abstract：:An increasing interest in liver cancer stemness arises owing to its aggressive behavior and poor prognosis. CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. Thus, exploring the regulatory mechanism of CD133 expression is significant. In the present ...

journal_title：Cell death & disease

authors： Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y

更新日期：2019-06-13 00:00:00

abstract：:Type 2 diabetes is a chronic metabolic disorder, where failure to maintain normal glucose homoeostasis is associated with, and exacerbated by, obesity and the concomitant-elevated free fatty acid concentrations typically found in these patients. Hyperglycaemia and hyperlipidaemia together contribute to a decline in in...

journal_title：Cell death & disease

authors： Bagnati M,Ogunkolade BW,Marshall C,Tucci C,Hanna K,Jones TA,Bugliani M,Nedjai B,Caton PW,Kieswich J,Yaqoob MM,Ball GR,Marchetti P,Hitman GA,Turner MD

更新日期：2016-08-11 00:00:00

abstract：:Redox imbalance generates multiple cellular damages leading to oxidative stress-mediated pathological conditions such as neurodegenerative diseases and cancer progression. Therefore, maintenance of reactive oxygen species (ROS) homeostasis is most important that involves well-defined antioxidant machinery. In the pres...

journal_title：Cell death & disease

authors： Srivastava S,Sinha D,Saha PP,Marthala H,D'Silva P

更新日期：2014-08-28 00:00:00

abstract：:Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of Leydig cells expose...

journal_title：Cell death & disease

authors： Li MY,Zhu XL,Zhao BX,Shi L,Wang W,Hu W,Qin SL,Chen BH,Zhou PH,Qiu B,Gao Y,Liu BL

更新日期：2019-06-20 00:00:00

abstract：:Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

journal_title：Cell death & disease

authors： Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

更新日期：2020-01-30 00:00:00

abstract：:The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...

journal_title：Cell death & disease

authors： Kuo CJ,Wang ST,Lin CM,Chiu HC,Huang CR,Lee DY,Chang GD,Chou TC,Chen JW,Chen CS

更新日期：2018-03-07 00:00:00

abstract：:Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells and vascular endoth...

journal_title：Cell death & disease

authors： Jalili-Firoozinezhad S,Prantil-Baun R,Jiang A,Potla R,Mammoto T,Weaver JC,Ferrante TC,Kim HJ,Cabral JMS,Levy O,Ingber DE

更新日期：2018-02-14 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most prevalent form of malignant brain tumor. Amlexanox, a novel compound, has been shown to have anti-cancer potential. In this study, the anti-tumoral effects and the underlying mechanisms of amlexanox were investigated. Amlexanox significantly suppressed proliferation and invasi...

journal_title：Cell death & disease

authors： Liu Y,Lu J,Zhang Z,Zhu L,Dong S,Guo G,Li R,Nan Y,Yu K,Zhong Y,Huang Q

更新日期：2017-08-31 00:00:00

abstract：:Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...

journal_title：Cell death & disease

authors： Li TT,Jia LX,Zhang WM,Li XY,Zhang J,Li YL,Li HH,Qi YF,Du J

更新日期：2016-06-09 00:00:00

abstract：:Cornelia de Lange Syndrome is a severe genetic disorder characterized by malformations affecting multiple systems, with a common feature of severe mental retardation. Genetic variants within four genes (NIPBL (Nipped-B-like), SMC1A, SMC3, and HDAC8) are believed to be responsible for the majority of cases; all these g...

journal_title：Cell death & disease

authors： Pistocchi A,Fazio G,Cereda A,Ferrari L,Bettini LR,Messina G,Cotelli F,Biondi A,Selicorni A,Massa V

更新日期：2013-10-17 00:00:00

abstract：:The pressure towards innovation and creation of new model systems in regenerative medicine and cancer research has fostered the development of novel potential therapeutic applications. Kidney injuries provoke a high request of organ transplants making it the most demanding system in the field of regenerative medicine....

journal_title：Cell death & disease

authors： Grassi L,Alfonsi R,Francescangeli F,Signore M,De Angelis ML,Addario A,Costantini M,Flex E,Ciolfi A,Pizzi S,Bruselles A,Pallocca M,Simone G,Haoui M,Falchi M,Milella M,Sentinelli S,Di Matteo P,Stellacci E,Gallucci M,

更新日期：2019-02-27 00:00:00

abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

journal_title：Cell death & disease

authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

更新日期：2014-11-20 00:00:00

abstract：:The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron t...

journal_title：Cell death & disease

authors： Sreedhar A,Aguilera-Aguirre L,Singh KK

更新日期：2020-06-09 00:00:00

abstract：:BMP2 expression is spatiotemporally correlated with embryo implantation and is crucial for endometrial decidualization and fertility in mice. BMP2 has been reported to increase the mesenchymal adhesion molecule N-cadherin and enhance cell invasion in cancer cells; moreover, studies suggest that N-cadherin promotes pla...

journal_title：Cell death & disease

authors： Zhao HJ,Klausen C,Li Y,Zhu H,Wang YL,Leung PCK

更新日期：2018-02-07 00:00:00

abstract：:Cognitive aging is a leading public health concern with the increasing aging population, but there is still lack of specific interventions directed against it. Recent studies have shown that cognitive function is intimately affected by systemic milieu in aging brain, and improvement of systemic environment in aging br...

journal_title：Cell death & disease

authors： Cao N,Liao T,Liu J,Fan Z,Zeng Q,Zhou J,Pei H,Xi J,He L,Chen L,Nan X,Jia Y,Yue W,Pei X

更新日期：2017-08-10 00:00:00

abstract：:Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocation from mitochondr...

journal_title：Cell death & disease

authors： Wang C,He C,Lu S,Wang X,Wang L,Liang S,Wang X,Piao M,Cui J,Chi G,Ge P

更新日期：2020-08-14 00:00:00

abstract：:Epidermal keratinocyte differentiation on the body surface is a carefully choreographed process that leads to assembly of a barrier that is essential for life. Perturbation of keratinocyte differentiation leads to disease. Activator protein 1 (AP1) transcription factors are key controllers of this process. We have sho...

journal_title：Cell death & disease

authors： Rorke EA,Adhikary G,Young CA,Rice RH,Elias PM,Crumrine D,Meyer J,Blumenberg M,Eckert RL

更新日期：2015-02-19 00:00:00

abstract：:The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

journal_title：Cell death & disease

authors： Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

更新日期：2016-10-27 00:00:00

abstract：:ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechan...

journal_title：Cell death & disease

authors： Chen Z,Wu C,Liu Y,Li H,Zhu Y,Huang C,Lin H,Qiao Q,Huang M,Zhu Q,Wang L

更新日期：2020-08-22 00:00:00

abstract：:The PDF and HTML versions of the article have been updated to include the Creative Commons Attribution 4.0 International License information. ...

journal_title：Cell death & disease

authors： Jiang Q,Wang F,Shi L,Zhao X,Gong M,Liu W,Song C,Li Q,Chen Y,Wu H,Han D

更新日期：2018-07-16 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Erythropoietin (EPO) is an evolutionarily conserved hormone well documented for its erythropoietic role via binding the homodimeric EPO receptor (EPOR)2. In past decades, evidence has proved that EPO acts far beyond erythropoiesis. By binding the tissue-protective receptor (TPR), EPO suppresses proinflammatory cytokin...

journal_title：Cell death & disease

authors： Peng B,Kong G,Yang C,Ming Y

更新日期：2020-02-03 00:00:00

abstract：:As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

journal_title：Cell death & disease

authors： He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

更新日期：2020-06-05 00:00:00

abstract：:Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer's disease, catabolises heme to biliverdin, Fe2+ and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K+ efflux as an early step in the apoptotic cascade. Sin...

journal_title：Cell death & disease

authors： Hettiarachchi N,Dallas M,Al-Owais M,Griffiths H,Hooper N,Scragg J,Boyle J,Peers C

更新日期：2014-12-11 00:00:00

abstract：:Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the β-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated β-catenin supports T. gondii multiplication which is arres...

journal_title：Cell death & disease

authors： Majumdar T,Sharma S,Kumar M,Hussain MA,Chauhan N,Kalia I,Sahu AK,Rana VS,Bharti R,Haldar AK,Singh AP,Mazumder S

更新日期：2019-02-15 00:00:00