Erythropoietin and its derivatives: from tissue protection to immune regulation.

abstract：:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...

journal_title：Cell death & disease

authors： Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJ

更新日期：2015-05-07 00:00:00

abstract：:Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocation from mitochondr...

journal_title：Cell death & disease

authors： Wang C,He C,Lu S,Wang X,Wang L,Liang S,Wang X,Piao M,Cui J,Chi G,Ge P

更新日期：2020-08-14 00:00:00

abstract：:Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, we show that the spe...

journal_title：Cell death & disease

authors： Schüll S,Günther SD,Brodesser S,Seeger JM,Tosetti B,Wiegmann K,Pongratz C,Diaz F,Witt A,Andree M,Brinkmann K,Krönke M,Wiesner RJ,Kashkar H

更新日期：2015-03-12 00:00:00

abstract：:HFM1 (helicase for meiosis 1) is widely recognized as an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. HFM1 is a candidate gene of premature ovarian failure (POF), hence it is also known as POF9. However, the roles of HFM1 in mammalian oocytes remain uncertain. To investigate the functions of ...

journal_title：Cell death & disease

authors： Wang H,Zhong C,Yang R,Yin Y,Tan R,Gao L,Gao C,Cui Y,Pu D,Wu J

更新日期：2020-06-30 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27. EZH2 is overexpressed in metastatic prostate cancer and has been shown to promote cell proliferation and metastasis. Here we show that EZH2 ...

journal_title：Cell death & disease

authors： Zhang Q,Padi SK,Tindall DJ,Guo B

更新日期：2014-10-23 00:00:00

abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

journal_title：Cell death & disease

authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

更新日期：2017-06-29 00:00:00

abstract：:Mitochondrial dysfunction and synaptic damage are critical early features of Alzheimer's disease (AD) associated with amyloid β (Aβ) and τ. We previously reported that the scaffolding protein RanBP9, which is overall increased in AD, simultaneously promotes Aβ generation and focal adhesion disruption by accelerating t...

journal_title：Cell death & disease

authors： Liu T,Roh SE,Woo JA,Ryu H,Kang DE

更新日期：2013-01-24 00:00:00

abstract：:Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1α and HIF-2α, emerging evidence suggests differences between both molecules in terms of transcriptiona...

journal_title：Cell death & disease

authors： Zhao J,Du F,Shen G,Zheng F,Xu B

更新日期：2015-01-15 00:00:00

abstract：:The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

journal_title：Cell death & disease

authors： Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

更新日期：2013-12-05 00:00:00

abstract：:Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor...

journal_title：Cell death & disease

authors： Dong L,Pu Y,Zhang L,Qi Q,Xu L,Li W,Wei C,Wang X,Zhou S,Zhu J,Wang X,Liu F,Chen X,Su C

更新日期：2018-02-13 00:00:00

abstract：:Thyroid hormone (TH) plays a crucial role in neurodevelopment, but its function and specific mechanisms remain unclear after traumatic brain injury (TBI). Here we found that treatment with triiodothyronine (T3) ameliorated the progression of neurological deficits in mice subjected to TBI. The data showed that T3 reduc...

journal_title：Cell death & disease

authors： Lin C,Li N,Chang H,Shen Y,Li Z,Wei W,Chen H,Lu H,Ji J,Liu N

更新日期：2020-08-09 00:00:00

abstract：:The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast cancer samples, could promote cell proliferation and tumorigenesis. However, whether TSP50 also has a key role i...

journal_title：Cell death & disease

authors： Song ZB,Ni JS,Wu P,Bao YL,Liu T,Li M,Fan C,Zhang WJ,Sun LG,Huang YX,Li YX

更新日期：2015-03-26 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. Phosphorylation of the receptor's ligand-binding domain at serine 273 has been shown to change the expression of a large number of genes implicated in obesity. The d...

journal_title：Cell death & disease

authors： Jurkowski W,Roomp K,Crespo I,Schneider JG,Del Sol A

更新日期：2011-08-11 00:00:00

abstract：:Circular RNAs (circRNAs) have been shown to play critical roles in cancer biology, but their functions in nonalcoholic steatohepatitis (NASH) remain unexplored. Full length of circRNA_002581 was amplified and sequenced, followed by RNA immunoprecipitation, RNA-Fluorescence in Situ Hybridization and dual luciferase rep...

journal_title：Cell death & disease

authors： Jin X,Gao J,Zheng R,Yu M,Ren Y,Yan T,Huang Y,Li Y

更新日期：2020-02-13 00:00:00

abstract：:Recent evidence indicates that long noncoding RNAs (lncRNAs) have a critical role in the regulation of cellular processes such as differentiation, proliferation, and metastasis. These lncRNAs are dysregulated in a variety of cancers and many function as tumor suppressors; however, the regulatory factors involved in si...

journal_title：Cell death & disease

authors： Sun M,Liu XH,Lu KH,Nie FQ,Xia R,Kong R,Yang JS,Xu TP,Liu YW,Zou YF,Lu BB,Yin R,Zhang EB,Xu L,De W,Wang ZX

更新日期：2014-06-26 00:00:00

abstract：:High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated...

journal_title：Cell death & disease

authors： Peng Y,Yang C,Shi X,Li L,Dong H,Liu C,Fang Z,Wang Z,Ming S,Liu M,Xie B,Gao X,Sun Y

更新日期：2019-01-15 00:00:00

abstract：:Unloading-induced bone loss is a threat to human health and can eventually result in osteoporotic fractures. Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identifi...

journal_title：Cell death & disease

authors： Wang K,Wang Y,Hu Z,Zhang L,Li G,Dang L,Tan Y,Cao X,Shi F,Zhang S,Zhang G

更新日期：2020-05-19 00:00:00

abstract：:New spinal cord injury (SCI) cases are frequently due to non-traumatic causes, including vascular disorders. To develop mechanism-based neuroprotective strategies for acute SCI requires full understanding of the early pathophysiological changes to prevent disability and paralysis. The aim of our study was to identify ...

journal_title：Cell death & disease

authors： Bianchetti E,Mladinic M,Nistri A

更新日期：2013-07-04 00:00:00

abstract：:Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly reduced infarct size, decreased troponin T levels and improved cardiac...

journal_title：Cell death & disease

authors： Wu QF,Qian C,Zhao N,Dong Q,Li J,Wang BB,Chen L,Yu L,Han B,Du YM,Liao YH

更新日期：2017-05-25 00:00:00

abstract：:β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

journal_title：Cell death & disease

authors： Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

更新日期：2014-10-16 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...

journal_title：Cell death & disease

authors： Xiao K,He W,Guan W,Hou F,Yan P,Xu J,Zhou T,Liu Y,Xie L

更新日期：2020-10-15 00:00:00

abstract：:Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin ...

journal_title：Cell death & disease

authors： Chen SS,Tang CH,Chie MJ,Tsai CH,Fong YC,Lu YC,Chen WC,Lai CT,Wei CY,Tai HC,Chou WY,Wang SW

更新日期：2019-01-10 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

journal_title：Cell death & disease

authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

更新日期：2013-10-24 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

journal_title：Cell death & disease

authors： Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

更新日期：2020-01-16 00:00:00

abstract：:Erythropoietin (EPO) has been well known as a hematopoietic cytokine over the past decades. However, recent reports have demonstrated that EPO plays a neuroprotective role in the central nervous system, and EPO has been considered as a therapeutic target in neurodegenerative diseases such as ischemic stroke. Despite t...

journal_title：Cell death & disease

authors： Yoo SJ,Cho B,Lee D,Son G,Lee YB,Soo Han H,Kim E,Moon C,Moon C

更新日期：2017-08-17 00:00:00

abstract：:Homeostatic chemokines, such as CXCL12, can affect neuronal activity by the regulation of inhibitory and excitatory neurotransmission, but the mechanisms involved are still undefined. Our previous studies have shown that CXCL12 protects cortical neurons from excitotoxicity by promoting the function of the gene-repress...

journal_title：Cell death & disease

authors： Nicolai J,Burbassi S,Rubin J,Meucci O

更新日期：2010-04-01 00:00:00

abstract：:Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty acid (n-3 PUFA), which is largely contained in fish or fish oil, has been reported to promote cell viab...

journal_title：Cell death & disease

authors： Gao B,Han YH,Wang L,Lin YJ,Sun Z,Lu WG,Hu YQ,Li JQ,Lin XS,Liu BH,Jie Q,Yang L,Luo ZJ

更新日期：2016-05-26 00:00:00

abstract：:HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions ...

journal_title：Cell death & disease

authors： Ma HM,Cui N,Zheng PS

更新日期：2020-06-04 00:00:00

abstract：:Plant-derived dietary antioxidants have attracted considerable interest in recent past for their chemopreventive and cancer therapeutic abilities in animal models. Thymoquinone (TQ) is the major bioactive constituent of volatile oil of Nigella sativa and has been shown to exert various pharmacological properties, such...

journal_title：Cell death & disease

authors： Zubair H,Khan HY,Sohail A,Azim S,Ullah MF,Ahmad A,Sarkar FH,Hadi SM

更新日期：2013-06-06 00:00:00

abstract：:Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that specifically recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif. The Pin1-mediated structural transformation posttranslationally regulates the biofunctions of multiple proteins. Pin1 is involved in many cel...

journal_title：Cell death & disease

authors： Chen Y,Wu YR,Yang HY,Li XZ,Jie MM,Hu CJ,Wu YY,Yang SM,Yang YB

更新日期：2018-08-29 00:00:00