Abstract:
:Chemotherapy is a standard treatment for non-small-cell lung cancer (NSCLC). However, the dose-limiting toxicity of drugs and the development of chemoresistance are major clinical challenges to successful management of NSCLC. Asian traditional medicine is gaining global attention as a non-toxic alternative to chemotherapy. BRM270 is an extract formulated from seven Asian medicinal plants that has been shown to inhibit tumor cell proliferation in diverse cancer types. We previously demonstrated that BRM270 suppresses tumorigenesis by negatively regulating nuclear factor-κB signaling in multidrug-resistant cancer stem cells (CSCs). In this study we report that the growth, migration, and invasion of normal human lung adenocarcinoma cells and their chemoresistant derivatives was inhibited by BRM270 treatment. Notably, BRM270 was found to modulate CSC self-renewal and tumor-initiating capacity via positive regulation of the miRNA-128. Thus, combination therapy with miRNA-128 and BRM270 may be an effective treatment strategy for chemoresistant NSCLC.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Kwon T,Chandimali N,Huynh DL,Zhang JJ,Kim N,Bak Y,Yoon DY,Yu DY,Lee JC,Gera M,Ghosh M,Park YH,Jeong DKdoi
10.1038/s41419-018-0277-7subject
Has Abstractpub_date
2018-02-14 00:00:00pages
244issue
2issn
2041-4889pii
10.1038/s41419-018-0277-7journal_volume
9pub_type
杂志文章abstract::Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol (RSV) possesses a variety of cardioprotective activities, however, little is known regarding the effects of RSV on mtROS homeostasis in en...
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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