How cell death shapes cancer.

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

journal_title：Cell death & disease

authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

更新日期：2016-02-04 00:00:00

abstract：:Cornelia de Lange Syndrome is a severe genetic disorder characterized by malformations affecting multiple systems, with a common feature of severe mental retardation. Genetic variants within four genes (NIPBL (Nipped-B-like), SMC1A, SMC3, and HDAC8) are believed to be responsible for the majority of cases; all these g...

journal_title：Cell death & disease

authors： Pistocchi A,Fazio G,Cereda A,Ferrari L,Bettini LR,Messina G,Cotelli F,Biondi A,Selicorni A,Massa V

更新日期：2013-10-17 00:00:00

abstract：:P300/CBP-associated factor (PCAF), a histone acetyltransferase (HAT), has been found to regulate numerous cell signaling pathways controlling cell fate by acetylating both histone and non-histone proteins. We previously reported that PCAF upregulates cell apoptosis by inactivating Serine/Threonine Protein Kinase 1 (AK...

journal_title：Cell death & disease

authors： Gai X,Tu K,Li C,Lu Z,Roberts LR,Zheng X

更新日期：2015-04-09 00:00:00

abstract：:In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor hydroxychloroquine (HCQ), we identified that it reduces the in vitro survival c...

journal_title：Cell death & disease

authors： Ruiz A,Rockfield S,Taran N,Haller E,Engelman RW,Flores I,Panina-Bordignon P,Nanjundan M

更新日期：2016-01-14 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...

journal_title：Cell death & disease

authors： Geismann C,Grohmann F,Sebens S,Wirths G,Dreher A,Häsler R,Rosenstiel P,Hauser C,Egberts JH,Trauzold A,Schneider G,Sipos B,Zeissig S,Schreiber S,Schäfer H,Arlt A

更新日期：2014-10-09 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer cells (NK)-mediated elimination of tumor cells is mostly dependent on Granzyme B apoptotic pathway, which is regulated by the wild type (wt) p53 protein. Because TP53 inactivating mutations, frequently found in human tumors, could interfere with Granzyme B-mediated cell...

journal_title：Cell death & disease

authors： Chollat-Namy M,Ben Safta-Saadoun T,Haferssas D,Meurice G,Chouaib S,Thiery J

更新日期：2019-09-20 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN) regulates apoptosis and axonal growth in the developing and adult central nervous system (CNS). Here, we show that human PTEN C-terminal PDZ interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic CNS injury and stroke, highlighted by the find...

journal_title：Cell death & disease

authors： Shabanzadeh AP,D'Onofrio PM,Magharious M,Choi KAB,Monnier PP,Koeberle PD

更新日期：2019-07-29 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are conserved protein kinases that regulate a variety of important cellular signaling pathways. Among them, c-Jun N-terminal kinases (JNK) are known to be activated by various environmental stresses including virus infections. Previously, activation of the JNK pathway has been...

journal_title：Cell death & disease

authors： Fung TS,Liu DX

更新日期：2017-12-13 00:00:00

abstract：:We have previously shown that the combination of statins and taxanes was a powerful trigger of HGT-1 human gastric cancer cells' apoptosis1. Importantly, several genes involved in the "Central carbon metabolism pathway in cancer", as reported in the Kyoto Encyclopedia of Genes and Genomes, were either up- (ACLY, ERBB2...

journal_title：Cell death & disease

authors： Goulitquer S,Croyal M,Lalande J,Royer AL,Guitton Y,Arzur D,Durand S,Le Jossic-Corcos C,Bouchereau A,Potin P,Akoka S,Antignac JP,Krempf M,Ferchaud-Roucher V,Giraudeau P,Corcos L

更新日期：2018-07-03 00:00:00

abstract：:Dalbergia odorifera has been traditionally used as a medicine to treat many diseases. However, the role of 2,4,5-trimethoxyldalbergiquinol (TMDQ) isolated and extracted from D. odorifera in osteoblast function and the underlying molecular mechanisms remain poorly understood. The aim of this study was to investigate th...

journal_title：Cell death & disease

authors： Yun HM,Park KR,Quang TH,Oh H,Hong JT,Kim YC,Kim EC

更新日期：2015-07-16 00:00:00

abstract：:Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...

journal_title：Cell death & disease

authors： Li Y,Zhang L,Qu T,Tang X,Li L,Zhang G

更新日期：2017-07-06 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

journal_title：Cell death & disease

authors： Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

更新日期：2011-06-02 00:00:00

abstract：:Cannabinoids exert antiproliferative effects in a wide range of tumoral cells, including hepatocellular carcinoma (HCC) cells. In this study, we examined whether the PPARγ-activated pathway contributed to the antitumor effect of two cannabinoids, Δ9-tetrahydrocannabinol (THC) and JWH-015, against HepG2 and HUH-7 HCC c...

journal_title：Cell death & disease

authors： Vara D,Morell C,Rodríguez-Henche N,Diaz-Laviada I

更新日期：2013-05-02 00:00:00

abstract：:Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condens...

journal_title：Cell death & disease

authors： Messner B,Frotschnig S,Steinacher-Nigisch A,Winter B,Eichmair E,Gebetsberger J,Schwaiger S,Ploner C,Laufer G,Bernhard D

更新日期：2012-11-15 00:00:00

abstract：:Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated by accelerated ost...

journal_title：Cell death & disease

authors： Chen TH,Swarnkar G,Mbalaviele G,Abu-Amer Y

更新日期：2015-04-16 00:00:00

abstract：:Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 (CK2) induces aberrant NF-κB activation and as we observed elevated CK2 levels in GBM tumors, we investigated the potential of CK2 inhibitors (CK2...

journal_title：Cell death & disease

authors： Dixit D,Sharma V,Ghosh S,Mehta VS,Sen E

更新日期：2012-02-09 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:Although it is becoming increasingly evident that maternal starvation during pregnancy can have permanent effects on a range of physiological processes in the offspring, scant information is available about the consequence of such condition for oogenesis and hence for lifetime reproductive success of progeny in mammal...

journal_title：Cell death & disease

authors： Wang JJ,Yu XW,Wu RY,Sun XF,Cheng SF,Ge W,Liu JC,Li YP,Liu J,Zou SH,De Felici M,Shen W

更新日期：2018-05-01 00:00:00

abstract：:Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

journal_title：Cell death & disease

authors： Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

更新日期：2011-12-08 00:00:00

abstract：:Cellular acetylation homeostasis is a kinetic balance precisely controlled by histone acetyl-transferase (HAT) and histone deacetylase (HDAC) activities. The loss of the counterbalancing function of basal HAT activity alters the precious HAT:HDAC balance towards enhanced histone deacetylation, resulting in a loss of a...

journal_title：Cell death & disease

authors： Wu Y,Ma S,Xia Y,Lu Y,Xiao S,Cao Y,Zhuang S,Tan X,Fu Q,Xie L,Li Z,Yuan Z

更新日期：2017-01-26 00:00:00

abstract：:The 37/67 kDa laminin receptor (LAMR) is a multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly. LAMR is important for cell viability; however, it is unclear which of its functions are essential. We developed a silent mutant...

journal_title：Cell death & disease

authors： Scheiman J,Jamieson KV,Ziello J,Tseng JC,Meruelo D

更新日期：2010-01-01 00:00:00

abstract：:SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain tissues but reduced or absent in glioma tissues. Howev...

journal_title：Cell death & disease

authors： Wu R,Yan Y,Ma C,Chen H,Dong Z,Wang Y,Liu Y,Liu M,Yang L

更新日期：2019-05-28 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

journal_title：Cell death & disease

authors： Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

更新日期：2020-01-16 00:00:00

abstract：:It is largely recognized that fibroblast activation protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) of many human carcinomas. Furthermore, FAP was recently also reported to be expressed in carcinoma cells of the breast, stomach, pancreatic ductal adenocarcinoma, colorectum, and uterine cervix. The c...

journal_title：Cell death & disease

authors： Wang H,Wu Q,Liu Z,Luo X,Fan Y,Liu Y,Zhang Y,Hua S,Fu Q,Zhao M,Chen Y,Fang W,Lv X

更新日期：2014-04-10 00:00:00

abstract：:The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have indicated that SLC15A3 transcripts are mainly expressed in the lymphatic system, however, its regulation and biological role in innate im...

journal_title：Cell death & disease

authors： Song F,Yi Y,Li C,Hu Y,Wang J,Smith DE,Jiang H

更新日期：2018-07-10 00:00:00

abstract：:Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure...

journal_title：Cell death & disease

authors： Wang L,Gundelach JH,Bram RJ

更新日期：2017-05-18 00:00:00

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:An increasing interest in liver cancer stemness arises owing to its aggressive behavior and poor prognosis. CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. Thus, exploring the regulatory mechanism of CD133 expression is significant. In the present ...

journal_title：Cell death & disease

authors： Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y

更新日期：2019-06-13 00:00:00