Abstract:
:SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain tissues but reduced or absent in glioma tissues. However, the functions of SASH1 in normal astrocytes and the reasons for the reductions in SASH1 levels in glioma tissues are unclear. In this study, we found that in astrocytes, SASH1 functions in cell adhesion. We observed that knockdown of SASH1 expression in cultured astrocytes significantly decreased cell adhesion and increased invasion. Conversely, overexpression of SASH1 in C6 cells markedly promoted cell adhesion and decreased cell invasion. In addition, we found that the expression level of one member of the integrin family, integrin β8, was significantly reduced in SASH1-downregulated astrocytes and elevated in SASH1-upregulated C6 cells. Furthermore, the results of methylation and ChIP assays showed that the methylation level of the SASH1 gene was markedly higher in C6 cells than in astrocytes and that HMGB1 could bind to the CpG islands of the SASH1 gene. HMGB1 overexpression in astrocytes significantly increased the methylation level of the SASH1 gene. This study reveals, for the first time, that HMGB1 contributes to the methylation of the SASH1 gene, and our findings suggest that methylation downregulates the expression of the SASH1 gene and later reduces integrin β8 expression, thereby reducing cell adhesion and promoting cell migration.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Wu R,Yan Y,Ma C,Chen H,Dong Z,Wang Y,Liu Y,Liu M,Yang Ldoi
10.1038/s41419-019-1645-7subject
Has Abstractpub_date
2019-05-28 00:00:00pages
417issue
6issn
2041-4889pii
10.1038/s41419-019-1645-7journal_volume
10pub_type
杂志文章abstract::Glioma patients commonly suffer from epileptic seizures. However, the mechanisms of glioma-associated epilepsy are far to be completely understood. Using glioma-neurons co-cultures, we found that tumor cells are able to deeply influence neuronal chloride homeostasis, by depolarizing the reversal potential of γ-aminobu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.437
更新日期:2014-10-30 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-1722-y
更新日期:2019-06-17 00:00:00
abstract::CEMIP (for "Cell migration-inducing protein" also called KIAA1199 and Hybid for "Hyaluronan-binding protein") expression is increased in cancers and described as a regulator of cell survival, growth and invasion. In rheumatoid arthritis, CEMIP is referred to as an angiogenic marker and participates in hyaluronic acid ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1377-8
更新日期:2019-02-04 00:00:00
abstract::Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, whi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.486
更新日期:2013-12-12 00:00:00
abstract::The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.347
更新日期:2016-02-18 00:00:00
abstract::Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and acquired resistance remain a ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-021-03414-3
更新日期:2021-01-26 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative disease characterized by Lewy body formation and progressive dopaminergic neuron death in the substantia nigra (SN). Genetic susceptibility is a strong risk factor for PD. Previously, a rare gain-of-function variant of GLUD2 glutamate dehydrogenase (T1492G) was re...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03043-2
更新日期:2020-10-22 00:00:00
abstract::Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1306-x
更新日期:2019-01-25 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.417
更新日期:2014-10-09 00:00:00
abstract::Autophagy is a pivotal intracellular process by which cellular macromolecules are degraded upon various stimuli. A failure in the degradation of autophagic substrates such as impaired organelles and protein aggregates leads to their accumulations, which are characteristics of many neurodegenerative diseases. Pharmacol...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.501
更新日期:2017-10-05 00:00:00
abstract::Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2326-2
更新日期:2020-02-18 00:00:00
abstract::Hypertension-induced cardiac hypertrophy and attenuated cardiac function are the major characteristics of early stage heart failure. Cardiomyocyte death in pathological cardiac conditions is the primary cause of heart failure and mortality. Our previous studies found that heat shock factor 1 (HSF1) protected cardiomyo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.320
更新日期:2017-08-10 00:00:00
abstract::Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this study, we found that U...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1170-0
更新日期:2018-11-21 00:00:00
abstract::Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...
journal_title:Cell death & disease
pub_type: 杂志文章,收录出版
doi:10.1038/cddis.2016.268
更新日期:2016-10-13 00:00:00
abstract::Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4+ CD25+ Foxp3+ T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β1-adrenergic...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1209-2
更新日期:2019-02-15 00:00:00
abstract::Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of Leydig cells expose...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1728-5
更新日期:2019-06-20 00:00:00
abstract::Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2453-9
更新日期:2020-04-22 00:00:00
abstract::Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.164
更新日期:2016-06-09 00:00:00
abstract::Cancer cells have developed chemoresistance and have improved their survival through the upregulation of autophagic mechanisms that protect mitochondrial function. Here, we report that the traditional Chinese anticancer agent tubeimoside I (Tub), which is a potent inhibitor of autophagy, can promote mitochondria-assoc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02915-x
更新日期:2020-08-26 00:00:00
abstract::The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows that long noncoding RNAs (lncRNAs) play vital roles in cancer initiation and progression. However, the inherited...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02856-5
更新日期:2020-08-15 00:00:00
abstract::Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0204-3
更新日期:2018-02-07 00:00:00
abstract::Ionizing radiation (IR) response has been extensively investigated in BMSCs with an increasing consensus that this type of cells showed relative radiosensitivity in vitro analysis. However, the underlying mechanism of IR-induced injury of BMSCs has not been elucidated. In current study, the regulatory role of miR-22/R...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1373-z
更新日期:2019-03-07 00:00:00
abstract::Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2230-9
更新日期:2020-01-16 00:00:00
abstract::A cell-in-cell process refers to the invasion of one living cell into another homotypic or heterotypic cell. Different from non-apoptotic death processes of internalized cells termed entosis or cannibalism, we previously reported an apoptotic cell-in-cell death occurring during heterotypic cell-in-cell formation. In t...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.352
更新日期:2013-10-10 00:00:00
abstract::It is long established that tumour-initiating cancer stem cells (CSCs) possess chemoresistant properties. However, little is known of the mechanisms involved, particularly with respect to the organisation of CSCs as stem-progenitor-differentiated cell hierarchies. Here we aimed to elucidate the relationship between CS...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.379
更新日期:2017-10-19 00:00:00
abstract::The original version of this Article contained an error in Fig. 1, in which a number of incorrect fluorescence images were inadvertently incorporated into the panel. This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-1422-7
更新日期:2019-03-12 00:00:00
abstract::Correction to: NPG Asia Materials (2018) https://doi.org/10.1038/s41427-018-0014-9 published online on 16 April 2018. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-018-0639-1
更新日期:2018-05-24 00:00:00
abstract::The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have indicated that SLC15A3 transcripts are mainly expressed in the lymphatic system, however, its regulation and biological role in innate im...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0809-1
更新日期:2018-07-10 00:00:00
abstract::New spinal cord injury (SCI) cases are frequently due to non-traumatic causes, including vascular disorders. To develop mechanism-based neuroprotective strategies for acute SCI requires full understanding of the early pathophysiological changes to prevent disability and paralysis. The aim of our study was to identify ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.237
更新日期:2013-07-04 00:00:00
abstract::Podocyte damage is commonly accompanied by destabilization of the podocalyxin (PC)/ezrin complex. Serum- and glucocorticoid-inducible kinase 3 (SGK3) plays a role in the maintenance of podocyte function, but the details of this role are poorly understood. Herein we demonstrated that SGK3 and its downstream target prot...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1161-1
更新日期:2018-11-01 00:00:00