Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease.

abstract：:We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...

journal_title：Cell death & disease

authors： Van de Casteele M,Leuckx G,Baeyens L,Cai Y,Yuchi Y,Coppens V,De Groef S,Eriksson M,Svensson C,Ahlgren U,Ahnfelt-Rønne J,Madsen OD,Waisman A,Dor Y,Jensen JN,Heimberg H

更新日期：2013-03-07 00:00:00

abstract：:Following the publication of this article, the authors realized there was an error in Figure 6H in which two versions of the figure appear.This does not impact the conclusions of the article. ...

journal_title：Cell death & disease

authors： Liu J,An P,Xue Y,Che D,Liu X,Zheng J,Liu Y,Yang C,Li Z,Yu B

更新日期：2019-08-21 00:00:00

abstract：:Proinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase tumor progression l...

journal_title：Cell death & disease

authors： Varin EM,Wojtusciszyn A,Broca C,Muller D,Ravier MA,Ceppo F,Renard E,Tanti JF,Dalle S

更新日期：2016-01-21 00:00:00

abstract：:Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that have the potency of inhibiting collagen synthesis and thus attenuating organ fibrosis. In this study, we found that flavones with 5, 7, 3', 4' hydroxy substituti...

journal_title：Cell death & disease

authors： Zhang Y,Wang J,Zhou S,Xie Z,Wang C,Gao Y,Zhou J,Zhang X,Li Q

更新日期：2019-02-11 00:00:00

abstract：:Many types of tumor cell are devoid of the extracellular matrix proteoglycan osteoglycin (Ogn), but its role in tumor biology is poorly studied. Here we show that RNAi of Ogn attenuates stress-triggered cell death, whereas its overexpression increases cell death. We found that the transcription factor C/EBPβ regulates...

journal_title：Cell death & disease

authors： Wassermann-Dozorets R,Rubinstein M

更新日期：2017-04-06 00:00:00

abstract：:Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology and pathogenesis of pre-eclampsia (PE). Moreover, defective trophoblast invasion may trigger poor maternal-fetal circulation and placental hypoxia, ...

journal_title：Cell death & disease

authors： Ou Y,Zhu L,Wei X,Bai S,Chen M,Chen H,Zhang J

更新日期：2020-06-25 00:00:00

abstract：:Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. To further explore, mic...

journal_title：Cell death & disease

authors： Zhao CC,Jiao Y,Zhang YY,Ning J,Zhang YR,Xu J,Wei W,Kang-Sheng G

更新日期：2019-03-15 00:00:00

abstract：:Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor...

journal_title：Cell death & disease

authors： Dong L,Pu Y,Zhang L,Qi Q,Xu L,Li W,Wei C,Wang X,Zhou S,Zhu J,Wang X,Liu F,Chen X,Su C

更新日期：2018-02-13 00:00:00

abstract：: ...

journal_title：Cell death & disease

authors： Gatie MI,Assabgui AR,Kelly GM

更新日期：2018-10-22 00:00:00

abstract：:Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits ...

journal_title：Cell death & disease

authors： Yu F,Zhang W,Yan C,Yan D,Zhou M,Chen J,Zhao X,Zhu A,Zhou J,Liu H,Sun H,Fu Y

更新日期：2020-08-12 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix producti...

journal_title：Cell death & disease

authors： Chen X,Shi C,Cao H,Chen L,Hou J,Xiang Z,Hu K,Han X

更新日期：2018-05-29 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both in patients and transgenic mouse models, which prompted us to investigate whether disease-specific...

journal_title：Cell death & disease

authors： L'Episcopo F,Drouin-Ouellet J,Tirolo C,Pulvirenti A,Giugno R,Testa N,Caniglia S,Serapide MF,Cisbani G,Barker RA,Cicchetti F,Marchetti B

更新日期：2016-04-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur ...

journal_title：Cell death & disease

authors： Wang P,Song X,Cao D,Cui K,Wang J,Utpatel K,Shang R,Wang H,Che L,Evert M,Zhao K,Calvisi DF,Chen X

更新日期：2020-02-04 00:00:00

abstract：:During reproductive life, the mammary epithelium undergoes consecutive cycles of proliferation, differentiation and apoptosis. Doing so relies on the retained proliferative capacity, prolonged lifespan and developmental potency of mammary stem cells (MaSCs). ΔNp63α, the predominant TP63 isoform in mammary epithelia, i...

journal_title：Cell death & disease

authors： DeCastro AJ,Dunphy KA,Hutchinson J,Balboni AL,Cherukuri P,Jerry DJ,DiRenzo J

更新日期：2013-02-28 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular degeneration of the retinal pigment epithelium (RPE) and photoreceptors, and the RPE oxidative damage/dystrophy is at the core of the disease. Recent population/patients-based stud...

journal_title：Cell death & disease

authors： Ma H,Yang F,Ding XQ

更新日期：2020-01-13 00:00:00

abstract：:MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

journal_title：Cell death & disease

authors： Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

更新日期：2015-11-26 00:00:00

abstract：:Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) protei...

journal_title：Cell death & disease

authors： Yang C,Hu Y,Zhou B,Bao Y,Li Z,Gong C,Yang H,Wang S,Xiao Y

更新日期：2020-11-08 00:00:00

abstract：:HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (Exp-t) pathway sugg...

journal_title：Cell death & disease

authors： Abbas W,Khan KA,Tripathy MK,Dichamp I,Keita M,Rohr O,Herbein G

更新日期：2012-04-05 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...

journal_title：Cell death & disease

authors： Su Y,Yuan J,Zhang F,Lei Q,Zhang T,Li K,Guo J,Hong Y,Bu G,Lv X,Liang S,Ou J,Zhou J,Luo B,Shang J

更新日期：2019-05-07 00:00:00

abstract：:Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...

journal_title：Cell death & disease

authors： Mao YX,Cai WJ,Sun XY,Dai PP,Li XM,Wang Q,Huang XL,He B,Wang PP,Wu G,Ma JF,Huang SB

更新日期：2018-06-04 00:00:00

abstract：:The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inh...

journal_title：Cell death & disease

authors： Fearn A,Situmorang GR,Fox C,Oakley F,Howarth R,Wilson CL,Kiosia A,Robson MG,Mann DA,Moles A,Sheerin NS

更新日期：2017-06-15 00:00:00

abstract：:Calcium ions play a critical role in neuronal cell death. Pigment epithelium-derived factor (PEDF) is a promising neuroprotective protein for photoreceptor cells but the mechanisms mediating its effects against retinal degeneration are still not well characterized. We addressed this question in the rd1 degenerating mo...

journal_title：Cell death & disease

authors： Comitato A,Subramanian P,Turchiano G,Montanari M,Becerra SP,Marigo V

更新日期：2018-05-01 00:00:00

abstract：:Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell deat...

journal_title：Cell death & disease

authors： Kleih M,Böpple K,Dong M,Gaißler A,Heine S,Olayioye MA,Aulitzky WE,Essmann F

更新日期：2019-11-07 00:00:00

abstract：:Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular carcinoma (HCC) is still not fully understood. In this study, we aimed to investigate the expression pattern and function roles of SPATS2 i...

journal_title：Cell death & disease

authors： Dong G,Zhang S,Shen S,Sun L,Wang X,Wang H,Wu J,Liu T,Wang C,Wang H,Lu T,Rao B,Ren Z

更新日期：2020-10-09 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance...

journal_title：Cell death & disease

authors： Wei L,Ye H,Li G,Lu Y,Zhou Q,Zheng S,Lin Q,Liu Y,Li Z,Chen R

更新日期：2018-10-18 00:00:00

abstract：:Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-se...

journal_title：Cell death & disease

authors： Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ

更新日期：2015-02-26 00:00:00

abstract：:The role of autophagy in cancer onset and progression appears still controversial. On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. In addition, autophagy interpheres with cell cycle pr...

journal_title：Cell death & disease

authors： Buccarelli M,Marconi M,Pacioni S,De Pascalis I,D'Alessandris QG,Martini M,Ascione B,Malorni W,Larocca LM,Pallini R,Ricci-Vitiani L,Matarrese P

更新日期：2018-08-06 00:00:00

abstract：:Highly conserved microRNA-9 (miR-9) has a critical role in various cellular processes including neurogenesis. However, its regulation by neurotropins that are known to mediate neurogenesis remains poorly defined. In this study, we identify platelet-derived growth factor-BB (PDGF-BB)-mediated upregulation of miR-9, whi...

journal_title：Cell death & disease

authors： Yang L,Chao J,Kook YH,Gao Y,Yao H,Buch SJ

更新日期：2013-12-12 00:00:00

abstract：:Glioma patients commonly suffer from epileptic seizures. However, the mechanisms of glioma-associated epilepsy are far to be completely understood. Using glioma-neurons co-cultures, we found that tumor cells are able to deeply influence neuronal chloride homeostasis, by depolarizing the reversal potential of γ-aminobu...

journal_title：Cell death & disease

authors： Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D

更新日期：2014-10-30 00:00:00