Abstract:
:Mounting evidence has revealed that impaired spiral artery remodeling, placental dysfunction, and inadequate trophoblast invasion are closely correlated with the etiology and pathogenesis of pre-eclampsia (PE). Moreover, defective trophoblast invasion may trigger poor maternal-fetal circulation and placental hypoxia, leading to PE. However, the detailed molecular pathology of PE remains unclear. Although circRNAs, as a new type of stable and abundant endogenous noncoding RNA, have been proven to be essential to the pathogenesis of various diseases, their role in PE requires further verification. In this context, it is necessary to unveil the roles of circRNAs in regulating the migration and invasion of extravillous trophoblasts. In this study, using quantitative real-time PCR, we confirmed that hsa_circ_0111277 was upregulated in PE placentas relative to the level in normal pregnancy placentas. In addition, positive correlations between hsa_circ_0111277 expression and PE-related factors (proteinuria level at 24 h and placental weight) were identified by Pearson's analysis based on the clinical data of 25 PE patients. Moreover, fluorescence in situ hybridization analysis illustrated that circ_0111277 was preferentially localized within the cytoplasm. Mechanistically, circ_0111277 sponged hsa-miR-494-3p in trophoblast cells to attenuate the latter's repression by regulating HTRA1/Notch-1 expression. In conclusion, trophoblast cell migration and invasion were shown to be promoted and modulated by the hsa_circ_0111277/miR-494-3p/HTRA1/Notch-1 axis, which provides useful insight for exploring a new therapeutic approach for PE.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Ou Y,Zhu L,Wei X,Bai S,Chen M,Chen H,Zhang Jdoi
10.1038/s41419-020-2679-6subject
Has Abstractpub_date
2020-06-25 00:00:00pages
479issue
6issn
2041-4889pii
10.1038/s41419-020-2679-6journal_volume
11pub_type
杂志文章abstract::Podocyte apoptosis is a major mechanism that leads to proteinuria in many chronic kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. The Rho family of small GTPases has been shown to be required in maintaining podocyte structure and functio...
journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1116-6
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1420-9
更新日期:2019-02-15 00:00:00
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journal_title:Cell death & disease
pub_type: 已发布勘误
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2376-5
更新日期:2020-03-13 00:00:00
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pub_type: 杂志文章
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更新日期:2020-10-28 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2014-03-27 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2295-5
更新日期:2020-02-06 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
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abstract:: ...
journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2018-10-22 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1700-4
更新日期:2019-06-12 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章,评审
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更新日期:2014-05-29 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1006-y
更新日期:2018-10-15 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2525-x
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journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.120
更新日期:2014-04-10 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2018-01-22 00:00:00
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journal_title:Cell death & disease
pub_type: 杂志文章
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更新日期:2016-11-03 00:00:00