Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma.

abstract：:Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression and intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin. The role of autophagy ...

journal_title：Cell death & disease

authors： Zhuang H,Wu F,Wei W,Dang Y,Yang B,Ma X,Han F,Li Y

更新日期：2019-02-25 00:00:00

abstract：:The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known as the electron t...

journal_title：Cell death & disease

authors： Sreedhar A,Aguilera-Aguirre L,Singh KK

更新日期：2020-06-09 00:00:00

abstract：:Anaplastic Thyroid Cancer (ATC) is an aggressive malignancy with limited therapeutic options and dismal patient survival. We have previously shown MADD to be differentially overexpressed in multiple cancer histologies and to contribute to tumor cell growth and survival. Therefore, we targeted MADD by gene silencing, e...

journal_title：Cell death & disease

authors： Saini S,Sripada L,Tulla K,Kumar P,Yue F,Kunda N,Maker AV,Prabhakar BS

更新日期：2019-02-13 00:00:00

abstract：:Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in a genetically induc...

journal_title：Cell death & disease

authors： Lodola F,Morone D,Denegri M,Bongianino R,Nakahama H,Rutigliano L,Gosetti R,Rizzo G,Vollero A,Buonocore M,Napolitano C,Condorelli G,Priori SG,Di Pasquale E

更新日期：2016-10-06 00:00:00

abstract：:Gastric cancer (GC) is one of the most frequent malignancies, and increasing evidence supports the contribution of microRNA (miRNAs) to cancer progression. miR-1254 has been confirmed to participate in the regulation of various cancers, while the function of miR-1254 in GC remains unknown. In this study, we investigat...

journal_title：Cell death & disease

authors： Jiang M,Shi L,Yang C,Ge Y,Lin L,Fan H,He Y,Zhang D,Miao Y,Yang L

更新日期：2019-01-10 00:00:00

abstract：:Macrophages are involved in tumor growth and progression. They infiltrate into tumors and cause inflammation, which creates a microenvironment favoring tumor growth and metastasis. However, certain stimuli may induce macrophages to act as tumor terminators. Here we report that the calcineurin B subunit (CnB) synergize...

journal_title：Cell death & disease

authors： Su Z,Yang R,Zhang W,Xu L,Zhong Y,Yin Y,Cen J,DeWitt JP,Wei Q

更新日期：2015-05-07 00:00:00

abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

journal_title：Cell death & disease

authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

更新日期：2017-06-29 00:00:00

abstract：:Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently ...

journal_title：Cell death & disease

authors： Luo W,Wu H,Ye Y,Li Z,Hao S,Kong L,Zheng X,Lin S,Nie Q,Zhang X

更新日期：2014-07-17 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Dry AMD is characterized by a progressive macular degeneration of the retinal pigment epithelium (RPE) and photoreceptors, and the RPE oxidative damage/dystrophy is at the core of the disease. Recent population/patients-based stud...

journal_title：Cell death & disease

authors： Ma H,Yang F,Ding XQ

更新日期：2020-01-13 00:00:00

abstract：:The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

journal_title：Cell death & disease

authors： Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

更新日期：2016-10-27 00:00:00

abstract：:Epidemiological studies show obvious gender differences in the incidence and the prognosis of bladder cancer (BCa). Estrogen receptor alpha (ERα) was recently shown to play a protective role in BCa. However, the mechanisms by which ERα mediates BCa progression need to be further elucidated. In the present study, we ex...

journal_title：Cell death & disease

authors： Wu L,Zhang M,Qi L,Zu X,Li Y,Liu L,Chen M,Li Y,He W,Hu X,Mo M,Ou Z,Wang L

更新日期：2019-08-27 00:00:00

abstract：:Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism is rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer cells ECA109 and Kyse150. We then found that Wnt signaling activity was higher in radioresistant cel...

journal_title：Cell death & disease

authors： Zhao Y,Yi J,Tao L,Huang G,Chu X,Song H,Chen L

更新日期：2018-04-01 00:00:00

abstract：:Proinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase tumor progression l...

journal_title：Cell death & disease

authors： Varin EM,Wojtusciszyn A,Broca C,Muller D,Ravier MA,Ceppo F,Renard E,Tanti JF,Dalle S

更新日期：2016-01-21 00:00:00

abstract：:The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology over time, but the m...

journal_title：Cell death & disease

authors： Parker A,Vaux L,Patterson AM,Modasia A,Muraro D,Fletcher AG,Byrne HM,Maini PK,Watson AJM,Pin C

更新日期：2019-02-06 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:Dalbergia odorifera has been traditionally used as a medicine to treat many diseases. However, the role of 2,4,5-trimethoxyldalbergiquinol (TMDQ) isolated and extracted from D. odorifera in osteoblast function and the underlying molecular mechanisms remain poorly understood. The aim of this study was to investigate th...

journal_title：Cell death & disease

authors： Yun HM,Park KR,Quang TH,Oh H,Hong JT,Kim YC,Kim EC

更新日期：2015-07-16 00:00:00

abstract：:The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). The purpose of the present study was to explore the clinical significance and underlying mechanisms of a significantly dysregulated lncRNA (NEAT1) in HGSOC. Our...

journal_title：Cell death & disease

authors： Yong W,Yu D,Jun Z,Yachen D,Weiwei W,Midie X,Xingzhu J,Xiaohua W

更新日期：2018-08-28 00:00:00

abstract：:The glutamate-induced excitotoxicity pathway has been reported in several neurodegenerative diseases. Molecules that inhibit the release of glutamate or cause the overactivation of glutamate receptors can minimize neuronal cell death in these diseases. Osmotin, a homolog of mammalian adiponectin, is a plant protein fr...

journal_title：Cell death & disease

authors： Shah SA,Lee HY,Bressan RA,Yun DJ,Kim MO

更新日期：2014-01-30 00:00:00

abstract：:Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant o...

journal_title：Cell death & disease

authors： Lei WW,Zhang KH,Pan XC,Wang DM,Hu Y,Yang YN,Song JG

更新日期：2010-05-20 00:00:00

abstract：:Bidirectional non-protein-coding RNAs are ubiquitously transcribed from the genome. Convergent sense and antisense transcripts may regulate each other. Here, we examined the convergent cis-noncoding rRNAs (nc-rRNAs) in A5 and E9 lung cancer models. Sense nc-rRNAs extending from rDNA intergenic region to internal trans...

journal_title：Cell death & disease

authors： Gee M,Gu Y,Fields JR,Shiao YH

更新日期：2012-03-15 00:00:00

abstract：:Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin ...

journal_title：Cell death & disease

authors： Chen SS,Tang CH,Chie MJ,Tsai CH,Fong YC,Lu YC,Chen WC,Lai CT,Wei CY,Tai HC,Chou WY,Wang SW

更新日期：2019-01-10 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been reported to be involved in a variety of human diseases, including cancers. However, their mechanisms have not yet been fully elucidated. We investigated lncRNA changes that may be associated with pancreatic cancer (PC) by analyzing published microarray data, and identified AGAP2...

journal_title：Cell death & disease

authors： Hui B,Ji H,Xu Y,Wang J,Ma Z,Zhang C,Wang K,Zhou Y

更新日期：2019-02-27 00:00:00

abstract：:The biological clock is an endogenous biological timing system, which controls metabolic functions in almost all organs. Nutrient metabolism, substrate processing, and detoxification are circadian controlled in livers. However, how the clock genes respond to toxins and influence toxicity keeps unclear. We identified t...

journal_title：Cell death & disease

authors： Ge W,Wang T,Zhao Y,Yang Y,Sun Q,Yang X,Gao Y,Xu X,Zhang J

更新日期：2021-01-12 00:00:00

abstract：:ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple ...

journal_title：Cell death & disease

authors： Li L,Su N,Zhou T,Zheng D,Wang Z,Chen H,Yuan S,Li W

更新日期：2018-02-02 00:00:00

abstract：:Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...

journal_title：Cell death & disease

authors： Hou S,Tian T,Qi D,Sun K,Yuan Q,Wang Z,Qin Z,Wu Z,Chen Z,Zhang J

更新日期：2018-02-15 00:00:00

abstract：:MicroRNAs (miRNAs) are important class of functional regulators involved in human cancers development, including colorectal cancer (CRC). Exploring aberrantly expressed miRNAs may provide us with new insights into the initiation and development of CRC by functioning as oncogenes or tumor suppressors. The aim of our st...

journal_title：Cell death & disease

authors： Chen X,Zeng K,Xu M,Liu X,Hu X,Xu T,He B,Pan Y,Sun H,Wang S

更新日期：2019-02-12 00:00:00

abstract：:The phosphoinositide 3-kinases (PI3Ks) are heterodimers consisting of the catalytic subunit p110 and the regulatory subunit p85. The PI3K/Akt pathway is strongly deregulated in breast cancer (BC) representing one of the mechanisms of resistance to therapies. Therefore, the identification of inhibitors of PI3K componen...

journal_title：Cell death & disease

authors： Folgiero V,Di Carlo SE,Bon G,Spugnini EP,Di Benedetto A,Germoni S,Pia Gentileschi M,Accardo A,Milella M,Morelli G,Bossi G,Mottolese M,Falcioni R

更新日期：2012-12-06 00:00:00

abstract：:Many recent studies have uncovered the necessary role for the receptor-interacting protein kinase 1 (RIP1) in regulating apoptosis and necrosis that cells undergo in response to various cellular stresses. However, the functional significance of RIP1 in promoting cancer cells survival remains poorly understood. Here, w...

journal_title：Cell death & disease

authors： Lei FX,Jin L,Liu XY,Lai F,Yan XG,Farrelly M,Guo ST,Zhao XH,Zhang XD

更新日期：2018-06-07 00:00:00

abstract：:SAM and SH3 domain-containing 1 (SASH1), a scaffold protein, is regarded as a tumor suppressor. Recent studies have verified the decreased expression of SASH1 in many tumors. Our previous clinical investigation found that SASH1 was widely expressed in normal brain tissues but reduced or absent in glioma tissues. Howev...

journal_title：Cell death & disease

authors： Wu R,Yan Y,Ma C,Chen H,Dong Z,Wang Y,Liu Y,Liu M,Yang L

更新日期：2019-05-28 00:00:00

abstract：:The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells. The serine/threonine kinase casein kinase 2 (CK2) has a well-reported role in prostate cancer resistance to apoptotic agents or anticancer drugs. However, the mechanistic understanding on how CK2 suppo...

journal_title：Cell death & disease

authors： de Thonel A,Hazoumé A,Kochin V,Isoniemi K,Jego G,Fourmaux E,Hammann A,Mjahed H,Filhol O,Micheau O,Rocchi P,Mezger V,Eriksson JE,Rangnekar VM,Garrido C

更新日期：2014-01-23 00:00:00