Abstract:
:Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Catenaccio A,Llavero Hurtado M,Diaz P,Lamont DJ,Wishart TM,Court FAdoi
10.1038/cddis.2017.489subject
Has Abstractpub_date
2017-11-09 00:00:00pages
e3166issue
11issn
2041-4889pii
cddis2017489journal_volume
8pub_type
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