4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.

abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

journal_title：Cell death & disease

authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

更新日期：2019-01-25 00:00:00

abstract：:Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's diseas...

journal_title：Cell death & disease

authors： Gradzka S,Thomas OS,Kretz O,Haimovici A,Vasilikos L,Wong WW,Häcker G,Gentle IE

更新日期：2018-05-01 00:00:00

abstract：:Holliday junction recognition protein (HJURP) refers to a histone H3 chaperone that has been implicated in different kinds of malignancies. Yet, its character in pancreatic cancer remains unclear. The expression of HJURP was assessed in PDAC tissues by RT-qPCR, immunoblotting, and immunohistochemistry. HJURP-deficient...

journal_title：Cell death & disease

authors： Wang CJ,Li X,Shi P,Ding HY,Liu YP,Li T,Lin PP,Wang YS,Zhang GQ,Cao Y

更新日期：2020-05-21 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease that is characterized by enhanced changes in stem cell differentiation and fibroblast proliferation. Resident mesenchymal stem cells (LR-MSCs) can undergo phenotype conversion to myofibroblasts to augment extracellular matrix producti...

journal_title：Cell death & disease

authors： Chen X,Shi C,Cao H,Chen L,Hou J,Xiang Z,Hu K,Han X

更新日期：2018-05-29 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent ...

journal_title：Cell death & disease

authors： Cao YY,Yu J,Liu TT,Yang KX,Yang LY,Chen Q,Shi F,Hao JJ,Cai Y,Wang MR,Lu WH,Zhang Y

更新日期：2018-01-16 00:00:00

abstract：:Therapeutic resistance of neoplasms is mainly attributed to gradual evolution of mutational profile1. Here, we demonstrate a microRNA-mediated mechanism that effectively improves fitness of SKBR3 mammary carcinoma cells by cytoplasmic reprogramming. The reprogramming is triggered by endogenous miR4673 transcribed from...

journal_title：Cell death & disease

authors： Dökümcü K,Simonian M,Farahani RM

更新日期：2018-10-19 00:00:00

abstract：:The link between tendon stem/progenitor cells (TSPCs) senescence and tendon aging has been well recognized. However, the cellular and molecular mechanisms of TSPCs senescence are still not fully understood. In present study, we investigated the role of Aquaporin 1 (AQP1) in TSPCs senescence. We showed that AQP1 expres...

journal_title：Cell death & disease

authors： Chen M,Li Y,Xiao L,Dai G,Lu P,Wang Y,Rui Y

更新日期：2020-03-18 00:00:00

abstract：:Diffuse large B cell lymphoma (DLBCL) is a common and fatal hematological malignancy. Long noncoding RNAs (lncRNAs) have emerged as crucial biomarkers and regulators in many cancers. Novel lncRNA biomarker in DLBCL needs to be investigated badly, as well as its function and molecular mechanism. To further explore, mic...

journal_title：Cell death & disease

authors： Zhao CC,Jiao Y,Zhang YY,Ning J,Zhang YR,Xu J,Wei W,Kang-Sheng G

更新日期：2019-03-15 00:00:00

abstract：:In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship between stem-cell expansion and genetic stability is poorly understood. Here, we demonstrate that within the n...

journal_title：Cell death & disease

authors： Estrada JC,Torres Y,Benguría A,Dopazo A,Roche E,Carrera-Quintanar L,Pérez RA,Enríquez JA,Torres R,Ramírez JC,Samper E,Bernad A

更新日期：2013-06-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...

journal_title：Cell death & disease

authors： Zhang Y,Li D,Jiang Q,Cao S,Sun H,Chai Y,Li X,Ren T,Yang R,Feng F,Li BA,Zhao Q

更新日期：2018-07-03 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

journal_title：Cell death & disease

authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

更新日期：2020-02-18 00:00:00

abstract：:The ubiquitination-proteasome and degradation system is an essential process that regulates protein homeostasis. This system is involved in the regulation of cell proliferation, differentiation and survival, and dysregulations in this system lead to pathologies including cancers. The ubiquitination system is an enzyma...

journal_title：Cell death & disease

authors： Sévère N,Dieudonné FX,Marie PJ

更新日期：2013-01-17 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...

journal_title：Cell death & disease

authors： Gatta V,D'Aurora M,Granzotto A,Stuppia L,Sensi SL

更新日期：2014-02-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC is a heterogeneous disease with multiple subtypes. BRG1, encoded by the SMARCA4 gene, is a key component of SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations of SMARCA4 occur ...

journal_title：Cell death & disease

authors： Wang P,Song X,Cao D,Cui K,Wang J,Utpatel K,Shang R,Wang H,Che L,Evert M,Zhao K,Calvisi DF,Chen X

更新日期：2020-02-04 00:00:00

abstract：:Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to dat...

journal_title：Cell death & disease

authors： Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

更新日期：2018-02-22 00:00:00

abstract：:After axotomy of embryonic hippocampal neurons in vitro, some of the axotomized axons lose their identity, and new axons arise and grow. This axotomy-induced axonogenesis requires importin, suggesting that some injury-induced signals are transported via axons to elicit axonogenesis after axotomy. In this study, we sho...

journal_title：Cell death & disease

authors： Ohara R,Fujita Y,Hata K,Nakagawa M,Yamashita T

更新日期：2011-06-23 00:00:00

abstract：:Reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress are paradoxically implicated in myocardial ischemia/reperfusion (I/R) injury and cardioprotection. However, the precise interpretation for the dual roles of ROS and its relationship with the ER stress during I/R remain elusive. Here we investigated th...

journal_title：Cell death & disease

authors： Wang ZH,Liu JL,Wu L,Yu Z,Yang HT

更新日期：2014-06-19 00:00:00

abstract：:Ewing sarcoma (ES) is the second most frequent childhood bone cancer driven by the EWS/FLI1 (EF) fusion protein. Genetically defined ES models are needed to understand how EF expression changes bone precursor cell differentiation, how ES arises and through which mechanisms of inhibition it can be targeted. We used mes...

journal_title：Cell death & disease

authors： Javaheri T,Kazemi Z,Pencik J,Pham HT,Kauer M,Noorizadeh R,Sax B,Nivarthi H,Schlederer M,Maurer B,Hofbauer M,Aryee DN,Wiedner M,Tomazou EM,Logan M,Hartmann C,Tuckermann JP,Kenner L,Mikula M,Dolznig H,Üren A,Richt

更新日期：2016-10-13 00:00:00

abstract：:Glucocorticoids (GCs) are metabolic hormones with immunosuppressive effects that have proven effective drugs against childhood acute lymphoblastic leukemia (ALL). Yet, the role of metabolic reprogramming in GC-induced ALL cell death is poorly understood. GCs efficiently block glucose uptake and metabolism in ALL cells...

journal_title：Cell death & disease

authors： Dyczynski M,Vesterlund M,Björklund AC,Zachariadis V,Janssen J,Gallart-Ayala H,Daskalaki E,Wheelock CE,Lehtiö J,Grandér D,Tamm KP,Nilsson R

更新日期：2018-08-28 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

journal_title：Cell death & disease

authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

更新日期：2020-10-14 00:00:00

abstract：:High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated...

journal_title：Cell death & disease

authors： Peng Y,Yang C,Shi X,Li L,Dong H,Liu C,Fang Z,Wang Z,Ming S,Liu M,Xie B,Gao X,Sun Y

更新日期：2019-01-15 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance...

journal_title：Cell death & disease

authors： Wei L,Ye H,Li G,Lu Y,Zhou Q,Zheng S,Lin Q,Liu Y,Li Z,Chen R

更新日期：2018-10-18 00:00:00

abstract：:The NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome is a multi-protein complex, aimed at producing IL-1β in response to danger signals which must be tightly regulated. Here we investigated the importance of the stress sensor, Heat Shock Protein 70 (HSP70) on NLRP3 inflammasome activation. H...

journal_title：Cell death & disease

authors： Martine P,Chevriaux A,Derangère V,Apetoh L,Garrido C,Ghiringhelli F,Rébé C

更新日期：2019-03-15 00:00:00

abstract：:CCAAT/enhancer binding protein beta (C/EBPβ), a transcription factor expressed in muscle satellite cells (SCs), inhibits the myogenic program and is downregulated early in differentiation. In a conditional null model in which C/EBPβ expression is knocked down in paired box protein 7+ (Pax7+) SCs, cardiotoxin (CTX) inj...

journal_title：Cell death & disease

authors： Marchildon F,Fu D,Lala-Tabbert N,Wiper-Bergeron N

更新日期：2016-02-25 00:00:00

abstract：:Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were therefore investig...

journal_title：Cell death & disease

authors： Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet AG,Oates M,Slupsky JR,Pettitt AR

更新日期：2012-08-16 00:00:00

abstract：:Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to produce 1-methylnicotinamide (MeN). We have previously shown that NNMT expression protected against neurotoxin-mediated cell death by increasing Complex I (CxI) activity, resulting in increased ATP synthesis. This was mediated via prote...

journal_title：Cell death & disease

authors： Thomas MG,Saldanha M,Mistry RJ,Dexter DT,Ramsden DB,Parsons RB

更新日期：2013-06-13 00:00:00

abstract：:Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known...

journal_title：Cell death & disease

authors： Zhang Z,Jiang D,Yang H,He Z,Liu X,Qin W,Li L,Wang C,Li Y,Li H,Xu H,Jin H,Qian Q

更新日期：2019-06-17 00:00:00