Tumor suppressive miR-6775-3p inhibits ESCC progression through forming a positive feedback loop with p53 via MAGE-A family proteins.

abstract：:Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis. Activation of the mechanistic target of rapamycin (mTOR) and hypoxia-inducible factor (HIF) transcription factors are crucial for the regulation of immune cell fu...

journal_title：Cell death & disease

authors： Zhu Q,Wang H,Jiang B,Ni X,Jiang L,Li C,Wang X,Zhang F,Ke B,Lu L

更新日期：2018-09-05 00:00:00

abstract：:Spermidine, a natural polyamine presented widely in mammalian cells, has been implicated to extend the lifespan of several model organisms by inducing autophagy. However, the effect of spermidine against neuronal damage has not yet been fully determined. In this study, neuronal cell injury was induced by treating PC12...

journal_title：Cell death & disease

authors： Yang Y,Chen S,Zhang Y,Lin X,Song Y,Xue Z,Qian H,Wang S,Wan G,Zheng X,Zhang L

更新日期：2017-04-06 00:00:00

abstract：:Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that have the potency of inhibiting collagen synthesis and thus attenuating organ fibrosis. In this study, we found that flavones with 5, 7, 3', 4' hydroxy substituti...

journal_title：Cell death & disease

authors： Zhang Y,Wang J,Zhou S,Xie Z,Wang C,Gao Y,Zhou J,Zhang X,Li Q

更新日期：2019-02-11 00:00:00

abstract：:In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and to exhibit anticancer effects. Graviola tree is an evergreen tree with its extracts (leafs and see...

journal_title：Cell death & disease

authors： Yiallouris A,Patrikios I,Johnson EO,Sereti E,Dimas K,De Ford C,Fedosova NU,Graier WF,Sokratous K,Kyriakou K,Stephanou A

更新日期：2018-07-09 00:00:00

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:Inactivation of the retinoblastoma protein (Rb) has a key role in tumorigenesis. It is well established that Rb function is largely regulated by a dynamic balance of phosphorylation and dephosphorylation. Although much research has been done to understand the mechanisms and function of RB phosphorylation, the regulati...

journal_title：Cell death & disease

authors： Tong Y,Ying H,Liu R,Li L,Bergholz J,Xiao ZX

更新日期：2015-02-12 00:00:00

abstract：:Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It is a well-known fact that JEV infects neural stem/progenitor cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, i...

journal_title：Cell death & disease

authors： Mukherjee S,Singh N,Sengupta N,Fatima M,Seth P,Mahadevan A,Shankar SK,Bhattacharyya A,Basu A

更新日期：2017-01-19 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, inv...

journal_title：Cell death & disease

authors： Wang H,Zhan M,Xu SW,Chen W,Long MM,Shi YH,Liu Q,Mohan M,Wang J

更新日期：2017-05-11 00:00:00

abstract：:Epidermal keratinocyte differentiation on the body surface is a carefully choreographed process that leads to assembly of a barrier that is essential for life. Perturbation of keratinocyte differentiation leads to disease. Activator protein 1 (AP1) transcription factors are key controllers of this process. We have sho...

journal_title：Cell death & disease

authors： Rorke EA,Adhikary G,Young CA,Rice RH,Elias PM,Crumrine D,Meyer J,Blumenberg M,Eckert RL

更新日期：2015-02-19 00:00:00

abstract：:Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...

journal_title：Cell death & disease

authors： Narayanan SP,Xu Z,Putluri N,Sreekumar A,Lemtalsi T,Caldwell RW,Caldwell RB

更新日期：2014-02-20 00:00:00

abstract：:Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...

journal_title：Cell death & disease

authors： Goto K,Tong KI,Ikura J,Okada H

更新日期：2011-12-01 00:00:00

abstract：:Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

journal_title：Cell death & disease

authors： Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

更新日期：2011-12-08 00:00:00

abstract：:The oncogenic human papillomavirus (HPV) E6/E7 proteins are essential for the onset and maintenance of HPV-associated malignancies. Here, we report that activation of the cellular ubiquitin-proteasome system (UPS) by the omega-3 fatty acid, docosahexaenoic acid (DHA), leads to proteasome-mediated degradation of E6/E7 ...

journal_title：Cell death & disease

authors： Jing K,Shin S,Jeong S,Kim S,Song KS,Park JH,Heo JY,Seo KS,Park SK,Kweon GR,Wu T,Park JI,Lim K

更新日期：2014-11-13 00:00:00

abstract：:Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...

journal_title：Cell death & disease

authors： Mao YX,Cai WJ,Sun XY,Dai PP,Li XM,Wang Q,Huang XL,He B,Wang PP,Wu G,Ma JF,Huang SB

更新日期：2018-06-04 00:00:00

abstract：:Granzyme B (GZMB) is a proapoptotic serine protease that is released by cytotoxic lymphocytes. However, GZMB can also be produced by other cell types and is capable of cleaving extracellular matrix (ECM) proteins. GZMB contributes to abdominal aortic aneurysm (AAA) through an extracellular, perforin-independent mechan...

journal_title：Cell death & disease

authors： Ang LS,Boivin WA,Williams SJ,Zhao H,Abraham T,Carmine-Simmen K,McManus BM,Bleackley RC,Granville DJ

更新日期：2011-09-08 00:00:00

abstract：:Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in a genetically induc...

journal_title：Cell death & disease

authors： Lodola F,Morone D,Denegri M,Bongianino R,Nakahama H,Rutigliano L,Gosetti R,Rizzo G,Vollero A,Buonocore M,Napolitano C,Condorelli G,Priori SG,Di Pasquale E

更新日期：2016-10-06 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcripti...

journal_title：Cell death & disease

authors： Tian YN,Chen HD,Tian CQ,Wang YQ,Miao ZH

更新日期：2020-01-28 00:00:00

abstract：:Unloading-induced bone loss is a threat to human health and can eventually result in osteoporotic fractures. Although the underlying molecular mechanism of unloading-induced bone loss has been broadly elucidated, the pathophysiological role of long noncoding RNAs (lncRNAs) in this process is unknown. Here, we identifi...

journal_title：Cell death & disease

authors： Wang K,Wang Y,Hu Z,Zhang L,Li G,Dang L,Tan Y,Cao X,Shi F,Zhang S,Zhang G

更新日期：2020-05-19 00:00:00

abstract：:Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...

journal_title：Cell death & disease

authors： Cai S,Chen Y,Shang Y,Cui J,Li Z,Li Y

更新日期：2018-02-15 00:00:00

abstract：:Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression and intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin. The role of autophagy ...

journal_title：Cell death & disease

authors： Zhuang H,Wu F,Wei W,Dang Y,Yang B,Ma X,Han F,Li Y

更新日期：2019-02-25 00:00:00

abstract：:Bone metastasis is a severe complication of advanced breast cancer, resulting in osteolysis and increased mortality in patients. Raddeanin A (RA), isolated from traditional Chinese herbs, is an oleanane-type triterpenoid saponin with anticancer potential. In this study, we investigated the effects of RA in breast canc...

journal_title：Cell death & disease

authors： Wang Q,Mo J,Zhao C,Huang K,Feng M,He W,Wang J,Chen S,Xie Z,Ma J,Fan S

更新日期：2018-03-07 00:00:00

abstract：:We have recently found that primary rat embryonic fibroblasts (REFs) could be immortalized by overexpression of the human mitochondrial ribosomal protein MRPS18-2 (S18-2). A derived cell line, designated 18IM, expressed the embryonic stem cell markers SSEA-1 and Sox2. Upon inoculation into severe combined immunodefici...

journal_title：Cell death & disease

authors： Yenamandra SP,Darekar SD,Kashuba V,Matskova L,Klein G,Kashuba E

更新日期：2012-01-19 00:00:00

abstract：:Skeletal muscle atrophy is one of the clinical symptoms of myotonic dystrophy type 1 (DM1). A decline in skeletal muscle regeneration is an important contributor to muscle atrophy. Skeletal muscle satellite cells (SSCs) drive skeletal muscle regeneration. Increased autophagy can reduce the proliferative capacity of SS...

journal_title：Cell death & disease

authors： Song KY,Guo XM,Wang HQ,Zhang L,Huang SY,Huo YC,Zhang G,Feng JZ,Zhang RR,Ma Y,Hu QZ,Qin XY

更新日期：2020-07-18 00:00:00

abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

journal_title：Cell death & disease

authors： Badley AD,Sainski A,Wightman F,Lewin SR

更新日期：2013-07-11 00:00:00

abstract：:Withanolide E, a steroidal lactone from Physalis peruviana, was found to be highly active for sensitizing renal carcinoma cells and a number of other human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Withanolide E, the most potent and least toxic of five TRAIL-se...

journal_title：Cell death & disease

authors： Henrich CJ,Brooks AD,Erickson KL,Thomas CL,Bokesch HR,Tewary P,Thompson CR,Pompei RJ,Gustafson KR,McMahon JB,Sayers TJ

更新日期：2015-02-26 00:00:00

abstract：:Cognitive aging is a leading public health concern with the increasing aging population, but there is still lack of specific interventions directed against it. Recent studies have shown that cognitive function is intimately affected by systemic milieu in aging brain, and improvement of systemic environment in aging br...

journal_title：Cell death & disease

authors： Cao N,Liao T,Liu J,Fan Z,Zeng Q,Zhou J,Pei H,Xi J,He L,Chen L,Nan X,Jia Y,Yue W,Pei X

更新日期：2017-08-10 00:00:00

abstract：:MEIS2 has an important role in development and organogenesis, and is implicated in the pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not clear. Here, we show that MEIS2 is highly expressed in human neuroblastoma cell lines and is required for neuroblastoma cell survival and prol...

journal_title：Cell death & disease

authors： Zha Y,Xia Y,Ding J,Choi JH,Yang L,Dong Z,Yan C,Huang S,Ding HF

更新日期：2014-09-11 00:00:00

abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

journal_title：Cell death & disease

authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

更新日期：2018-09-26 00:00:00

abstract：:Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals. MicroRNAs (miRNAs) have been reported to be potential therapeutic targets for many diseases, including breast cancer. Recently...

journal_title：Cell death & disease

authors： Pan S,Zhao X,Shao C,Fu B,Huang Y,Zhang N,Dou X,Zhang Z,Qiu Y,Wang R,Jin M,Kong D

更新日期：2021-01-04 00:00:00

abstract：:DEP-domain containing mTOR-interacting protein (DEPTOR), a natural mTOR inhibitor, has essential roles in several processes, including cell growth, metabolism, apoptosis, and immunity. DEPTOR expression has been shown to be diversely controlled at transcriptional levels in cell- and context-specific manners. However, ...

journal_title：Cell death & disease

authors： Cui D,Dai X,Gong L,Chen X,Wang L,Xiong X,Zhao Y

更新日期：2020-11-12 00:00:00