当前位置： SCI文献检索 > Cell Death & Disease期刊下所有文献 > HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53.

HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53.

Abstract：

:HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions deepened. Ectopic expression of HOXA5 restrained cell proliferation, decreased cell viability, and inhibited tumor formation in vitro and in vivo. Furthermore, the expression of HOXA5 could arrest cell cycle from G0/G1 to S phase. RNA-seq revealed that p21 and cyclinD1 were involved in this process. Moreover, the gene set enrichment analysis and the TOP/FOP reporter assay both suggested that HOXA5 could restrain the activity of the Wnt/β-catenin pathway. Further study using dual-luciferase reporter assay and quantitative chromatin immunoprecipitation assay demonstrated that HOXA5 could directly bind to the TAAT motif within the promoter of TP53 by its HD domain and transactivate TP53, which can upregulate p21. Altogether, our data suggest that HOXA5 inhibits the proliferation and neoplasia via repression activity of the Wnt/β-catenin pathway and transactivating TP53 in cervical cancer.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Ma HM,Cui N,Zheng PS

doi

10.1038/s41419-020-2629-3

subject

Has Abstract

pub_date

2020-06-04 00:00:00

pages

420

issue

6

issn

2041-4889

pii

10.1038/s41419-020-2629-3

journal_volume

11

pub_type

杂志文章

相关文献

Cell Death & Disease文献大全
  • LINC81507 act as a competing endogenous RNA of miR-199b-5p to facilitate NSCLC proliferation and metastasis via regulating the CAV1/STAT3 pathway.

    abstract：:Lung cancer is the leading cause of cancer-related mortality worldwide. Recently, accumulating data indicate that long noncoding RNAs (LncRNAs) function as novel crucial regulators of diverse biological processes, including proliferation and metastasis, in tumorigenesis. Lnc NONHSAT081507.1 (LINC81507) is associated w...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1740-9

    authors： Peng W,He D,Shan B,Wang J,Shi W,Zhao W,Peng Z,Luo Q,Duan M,Li B,Cheng Y,Dong Y,Tang F,Zhang C,Duan C

    更新日期：2019-07-11 00:00:00

  • E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.

    abstract：:The ubiquitination-proteasome and degradation system is an essential process that regulates protein homeostasis. This system is involved in the regulation of cell proliferation, differentiation and survival, and dysregulations in this system lead to pathologies including cancers. The ubiquitination system is an enzyma...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/cddis.2012.217

    authors： Sévère N,Dieudonné FX,Marie PJ

    更新日期：2013-01-17 00:00:00

  • Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.

    abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03281-4

    authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

    更新日期：2021-01-04 00:00:00

  • MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail.

    abstract：:MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.297

    authors： Zuo QF,Cao LY,Yu T,Gong L,Wang LN,Zhao YL,Xiao B,Zou QM

    更新日期：2015-11-26 00:00:00

  • Role of c-Abl and nephrin in podocyte cytoskeletal remodeling induced by angiotensin II.

    abstract：:Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0225-y

    authors： Ma Y,Yang Q,Zhong Z,Liang W,Zhang L,Yang Y,Ding G

    更新日期：2018-02-07 00:00:00

  • BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1α stability and MGMT expression.

    abstract：:Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particular...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2012.153

    authors： Persano L,Pistollato F,Rampazzo E,Della Puppa A,Abbadi S,Frasson C,Volpin F,Indraccolo S,Scienza R,Basso G

    更新日期：2012-10-18 00:00:00

  • DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania.

    abstract：:DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactivation of DDX3 leads ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.315

    authors： Padmanabhan PK,Zghidi-Abouzid O,Samant M,Dumas C,Aguiar BG,Estaquier J,Papadopoulou B

    更新日期：2016-10-13 00:00:00

  • Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.

    abstract：:Podocyte apoptosis is a major mechanism that leads to proteinuria in many chronic kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. The Rho family of small GTPases has been shown to be required in maintaining podocyte structure and functio...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.51

    authors： Huang Z,Zhang L,Chen Y,Zhang H,Zhang Q,Li R,Ma J,Li Z,Yu C,Lai Y,Lin T,Zhao X,Zhang B,Ye Z,Liu S,Wang W,Liang X,Liao R,Shi W

    更新日期：2016-03-17 00:00:00

  • MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells.

    abstract：:A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldow...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.10

    authors： Cardinali B,Cappella M,Provenzano C,Garcia-Manteiga JM,Lazarevic D,Cittaro D,Martelli F,Falcone G

    更新日期：2016-02-04 00:00:00

  • Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis.

    abstract：:The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis execution. However, the mechanisms that control MLKL activity are not completely understood. Here, we identify the molecular chaperone Hsp90 as ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.390

    authors： Zhao XM,Chen Z,Zhao JB,Zhang PP,Pu YF,Jiang SH,Hou JJ,Cui YM,Jia XL,Zhang SQ

    更新日期：2016-02-11 00:00:00

  • Cell death-based treatment of glioblastoma.

    abstract：:Cancer cells including glioblastoma have typically evolved multiple mechanisms to escape programmed cell death in order to maintain their survival. Defects in cell death mechanisms not only facilitate tumorigenesis but also ensure resistance to current anticancer therapies. This emphasizes that targeting cell death pa...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/s41419-017-0021-8

    authors： Fulda S

    更新日期：2018-01-25 00:00:00

  • Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells.

    abstract：:The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads to loss of viability...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1830-8

    authors： Willbold R,Wirth K,Martini T,Sültmann H,Bolenz C,Wittig R

    更新日期：2019-08-09 00:00:00

  • 2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt/β-catenin pathway.

    abstract：:Dalbergia odorifera has been traditionally used as a medicine to treat many diseases. However, the role of 2,4,5-trimethoxyldalbergiquinol (TMDQ) isolated and extracted from D. odorifera in osteoblast function and the underlying molecular mechanisms remain poorly understood. The aim of this study was to investigate th...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.185

    authors： Yun HM,Park KR,Quang TH,Oh H,Hong JT,Kim YC,Kim EC

    更新日期：2015-07-16 00:00:00

  • FOXF2 acts as a crucial molecule in tumours and embryonic development.

    abstract：:As a key member of the forkhead box transcription factors, forkhead box F2 (FOXF2) serves as a transcriptional regulator and regulates downstream gene expression in embryonic development, metabolism and in some common diseases, such as stroke and gastroparesis. Recent studies have shown that aberrant expression of FOX...

    journal_title：Cell death & disease

    pub_type： 杂志文章,评审

    doi：10.1038/s41419-020-2604-z

    authors： He W,Kang Y,Zhu W,Zhou B,Jiang X,Ren C,Guo W

    更新日期：2020-06-05 00:00:00

  • Downregulation of ASPP2 promotes gallbladder cancer metastasis and macrophage recruitment via aPKC-ι/GLI1 pathway.

    abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis due to early invasion and metastasis. However, the molecular mechanisms through which GBC cells interact with the tumor microenvironment (TME) remain poorly understood. Here, we examined the role of the tumor suppressor apoptosis-stimu...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1145-1

    authors： Tian L,Deng Z,Xu L,Yang T,Yao W,Ji L,Lu Y,Zhang J,Liu Y,Wang J

    更新日期：2018-11-02 00:00:00

  • Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells.

    abstract：:Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realized through autocrin...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2013.445

    authors： Severino V,Alessio N,Farina A,Sandomenico A,Cipollaro M,Peluso G,Galderisi U,Chambery A

    更新日期：2013-11-07 00:00:00

  • Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas.

    abstract：:We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2013.52

    authors： Van de Casteele M,Leuckx G,Baeyens L,Cai Y,Yuchi Y,Coppens V,De Groef S,Eriksson M,Svensson C,Ahlgren U,Ahnfelt-Rønne J,Madsen OD,Waisman A,Dor Y,Jensen JN,Heimberg H

    更新日期：2013-03-07 00:00:00

  • Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy.

    abstract：:The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.347

    authors： Yun JH,Park SW,Kim JH,Park YJ,Cho CH,Kim JH

    更新日期：2016-02-18 00:00:00

  • RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner.

    abstract：:Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03054-z

    authors： Liang YY,Deng XB,Lin XT,Jiang LL,Huang XT,Mo ZW,Yuan YW,Teh MT

    更新日期：2020-10-14 00:00:00

  • MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial-mesenchymal transition progression in bladder cancer.

    abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.331

    authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

    更新日期：2017-08-24 00:00:00

  • Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation.

    abstract：:Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages and dendritic cells susceptible to necroptotic death. We also observe...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2534-9

    authors： Wu YH,Chou TF,Young L,Hsieh FY,Pan HY,Mo ST,Brown SB,Chen RH,Kimchi A,Lai MZ

    更新日期：2020-05-04 00:00:00

  • Glucocorticoid resistance in chronic lymphocytic leukaemia is associated with a failure of upregulated Bim/Bcl-2 complexes to activate Bax and Bak.

    abstract：:Glucocorticoids (GCs) represent an important component of modern treatment regimens for fludarabine-refractory or TP53-defective chronic lymphocytic leukemia (CLL). However, GC therapy is not effective in all patients. The molecular mechanisms responsible for GC-induced apoptosis and resistance were therefore investig...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2012.102

    authors： Melarangi T,Zhuang J,Lin K,Rockliffe N,Bosanquet AG,Oates M,Slupsky JR,Pettitt AR

    更新日期：2012-08-16 00:00:00

  • Melatonin inhibits apoptotic cell death induced by Vibrio vulnificus VvhA via melatonin receptor 2 coupling with NCF-1.

    abstract：:Melatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0083-7

    authors： Lee SJ,Lee HJ,Jung YH,Kim JS,Choi SH,Han HJ

    更新日期：2018-01-19 00:00:00

  • Knockdown of long non-coding RNA HOTAIR increases miR-454-3p by targeting Stat3 and Atg12 to inhibit chondrosarcoma growth.

    abstract：:Current practices for the therapy of chondrosarcoma, including wide-margin surgical resection and chemotherapy, are less than satisfactory. Recently, emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) have an essential role in the initiation and progression of tumors. As a typical lncRNA, HOTAIR is...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.31

    authors： Bao X,Ren T,Huang Y,Sun K,Wang S,Liu K,Zheng B,Guo W

    更新日期：2017-02-09 00:00:00

  • Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death.

    abstract：:Upregulation of Smad7, an inhibitor of transforming growth factor-β1 (TGF-β1), occurs in sporadic colorectal cancer (CRC) and knockdown of Smad7 inhibits CRC cell growth, a phenomenon that associates with decreased expression of cell division cycle 25 homolog A and arrest of cells in the S phase of the cell cycle. The...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.103

    authors： De Simone V,Bevivino G,Sedda S,Izzo R,Laudisi F,Dinallo V,Franzè E,Colantoni A,Ortenzi A,Salvatori S,Rossi P,Sica GS,Fantini MC,Stolfi C,Monteleone G

    更新日期：2017-03-16 00:00:00

  • Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.

    abstract：:Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are poorly understood. This study first showed the protective effects of ADM on the pyroptosis and biological functions of Leydig cells expose...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1728-5

    authors： Li MY,Zhu XL,Zhao BX,Shi L,Wang W,Hu W,Qin SL,Chen BH,Zhou PH,Qiu B,Gao Y,Liu BL

    更新日期：2019-06-20 00:00:00

  • miR4673 improves fitness profile of neoplastic cells by induction of autophagy.

    abstract：:Therapeutic resistance of neoplasms is mainly attributed to gradual evolution of mutational profile1. Here, we demonstrate a microRNA-mediated mechanism that effectively improves fitness of SKBR3 mammary carcinoma cells by cytoplasmic reprogramming. The reprogramming is triggered by endogenous miR4673 transcribed from...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1088-6

    authors： Dökümcü K,Simonian M,Farahani RM

    更新日期：2018-10-19 00:00:00

  • The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.

    abstract：:G-protein-coupled receptor (GPCR)-related proteins are dysregulated and the GPCR CC-chemokine receptor 10 (CCR10) is significantly upregulated in inflammation-driven HCC. However, CCR10's role in inflammation-driven hepatocarcinogenesis remains unknown. The aim of this study was to evaluate the role of CCR10 in inflam...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0267-9

    authors： Wu Q,Chen JX,Chen Y,Cai LL,Wang XZ,Guo WH,Zheng JF

    更新日期：2018-02-14 00:00:00

  • WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.

    abstract：:WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.162

    authors： Sun Y,Cao L,Sheng X,Chen J,Zhou Y,Yang C,Deng T,Ma H,Feng P,Liu J,Tan W,Ye M

    更新日期：2017-04-13 00:00:00

  • The spontaneous differentiation and chromosome loss in iPSCs of human trisomy 18 syndrome.

    abstract：:Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.565

    authors： Li T,Zhao H,Han X,Yao J,Zhang L,Guo Y,Shao Z,Jin Y,Lai D

    更新日期：2017-10-26 00:00:00