Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.

abstract：:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy a...

journal_title：Cell death & disease

authors： Liu B,Wen X,Cheng Y

更新日期：2013-10-31 00:00:00

abstract：:T-cell-mediated immune responses aim to protect mammals against cancers and infections, and are also involved in the pathogenesis of various inflammatory or autoimmune diseases. Cellular uptake and the utilization of nutrients is closely related to the T-cell fate decision and function. Research in this area has yield...

journal_title：Cell death & disease

authors： Ren W,Liu G,Yin J,Tan B,Wu G,Bazer FW,Peng Y,Yin Y

更新日期：2017-03-02 00:00:00

abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

journal_title：Cell death & disease

authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

更新日期：2016-09-22 00:00:00

abstract：:The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...

journal_title：Cell death & disease

authors： Herreros-Pomares A,de-Maya-Girones JD,Calabuig-Fariñas S,Lucas R,Martínez A,Pardo-Sánchez JM,Alonso S,Blasco A,Guijarro R,Martorell M,Escorihuela E,Chiara MD,Duréndez E,Gandía C,Forteza J,Sirera R,Jantus-Lewintre E,Farr

更新日期：2019-09-10 00:00:00

abstract：:Adipogenesis is a process which induces or represses many genes in a way to drive irreversible changes of cell phenotypes; lipid accumulation, round cell-shape, secreting many adipokines. As a master transcription factor (TF), PPARγ2 induces several target genes to orchestrate these adipogenic changes. Thus induction ...

journal_title：Cell death & disease

authors： Park B,Chang S,Lee GJ,Kang B,Kim JK,Park H

更新日期：2019-01-08 00:00:00

abstract：:HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions ...

journal_title：Cell death & disease

authors： Ma HM,Cui N,Zheng PS

更新日期：2020-06-04 00:00:00

abstract：:Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation o...

journal_title：Cell death & disease

authors： Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

更新日期：2020-04-16 00:00:00

abstract：:Acute lung injury (ALI) is characterized by pulmonary endothelial and epithelial cell damage, and loss of the alveolar-capillary barrier. We have previously shown that P2X7 receptor (P2X7R), a cell death receptor, is specifically expressed in alveolar epithelial type I cells (AEC I). In this study, we hypothesized tha...

journal_title：Cell death & disease

authors： Guo Y,Mishra A,Weng T,Chintagari NR,Wang Y,Zhao C,Huang C,Liu L

更新日期：2014-06-12 00:00:00

abstract：:Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes l...

journal_title：Cell death & disease

authors： Huang X,Xiao S,Zhu X,Yu Y,Cao M,Zhang X,Li S,Zhu W,Wu F,Zheng X,Jin L,Xie C,Huang X,Zou P,Li X,Cui R

更新日期：2020-09-22 00:00:00

abstract：:Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular target of GCs are monocytes/macrophages. The role of GCs in monocyte survival is also debated. Although both granulocyte macrophage-colony stimulating factor (GM-CSF) and macrophage-CSF (M-...

journal_title：Cell death & disease

authors： Achuthan A,Aslam ASM,Nguyen Q,Lam PY,Fleetwood AJ,Frye AT,Louis C,Lee MC,Smith JE,Cook AD,Olshansky M,Turner SJ,Hamilton JA

更新日期：2018-02-15 00:00:00

abstract：:The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion o...

journal_title：Cell death & disease

authors： Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J

更新日期：2018-02-14 00:00:00

abstract：:Erythropoietin (EPO) has been well known as a hematopoietic cytokine over the past decades. However, recent reports have demonstrated that EPO plays a neuroprotective role in the central nervous system, and EPO has been considered as a therapeutic target in neurodegenerative diseases such as ischemic stroke. Despite t...

journal_title：Cell death & disease

authors： Yoo SJ,Cho B,Lee D,Son G,Lee YB,Soo Han H,Kim E,Moon C,Moon C

更新日期：2017-08-17 00:00:00

abstract：:Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions in cerebral ischemia remain largely unknown. Through an lncRNA array analysis in a rat model of focal cerebral ischemia/reperfusion (I/R), we have identified CAMK2D-associ...

journal_title：Cell death & disease

authors： Xu Q,Deng F,Xing Z,Wu Z,Cen B,Xu S,Zhao Z,Nepomuceno R,Bhuiyan MI,Sun D,Wang QJ,Ji A

更新日期：2016-03-31 00:00:00

abstract：:It is largely recognized that fibroblast activation protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) of many human carcinomas. Furthermore, FAP was recently also reported to be expressed in carcinoma cells of the breast, stomach, pancreatic ductal adenocarcinoma, colorectum, and uterine cervix. The c...

journal_title：Cell death & disease

authors： Wang H,Wu Q,Liu Z,Luo X,Fan Y,Liu Y,Zhang Y,Hua S,Fu Q,Zhao M,Chen Y,Fang W,Lv X

更新日期：2014-04-10 00:00:00

abstract：:Hepatocytes undergo the metaplasia into ductal biliary epithelial cells (BECs) in response to chronic injury, and subsequently contribute to liver regeneration. The mechanism underlying hepatocyte-to-ductal metaplasia has not been explored until now. In mouse models of liver fibrosis, a florid BEC response was observe...

journal_title：Cell death & disease

authors： Xu T,Lu Z,Xiao Z,Liu F,Chen Y,Wang Z,Zhu S,Song Y

更新日期：2020-03-23 00:00:00

abstract：:miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which miR-195 represses the tumorigenesis of NSCLC cells are not fully understood. We performed a high-throughput screen using an miRNA mimic library and con...

journal_title：Cell death & disease

authors： Yu X,Zhang Y,Cavazos D,Ma X,Zhao Z,Du L,Pertsemlidis A

更新日期：2018-02-07 00:00:00

abstract：:Aberrant re-activation of transcription factors occurs frequently in cancer. Recently, we found the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in a model of highly aggressive thyroid cancer, raising the hypothesis that these factors might be part of the program driving progre...

journal_title：Cell death & disease

authors： Gallo C,Fragliasso V,Donati B,Torricelli F,Tameni A,Piana S,Ciarrocchi A

更新日期：2018-08-29 00:00:00

abstract：:The process by which epithelial features are lost in favor of a mesenchymal phenotype is referred to as epithelial-mesenchymal transition (EMT). Most carcinomas use this mechanism to evade into neighboring tissues. Reduction or a loss of E-cadherin expression is a well-established hallmark of EMT. As a potent suppress...

journal_title：Cell death & disease

authors： Meng X,Kong DH,Li N,Zong ZH,Liu BQ,Du ZX,Guan Y,Cao L,Wang HQ

更新日期：2014-02-27 00:00:00

abstract：:As an important modality for the local control of colorectal cancer (CRC), radiotherapy or neoadjuvant radiotherapy is widely applied in the clinic, but radioresistance has become a major obstacle for CRC radiotherapy. Here we reported that B7-H3, an important costimulatory molecule, is associated with radioresistance...

journal_title：Cell death & disease

authors： Ma Y,Zhan S,Lu H,Wang R,Xu Y,Zhang G,Cao L,Shi T,Zhang X,Chen W

更新日期：2020-10-03 00:00:00

abstract：:Following publication of this article, it was brought to our attention that there was a typo in the References (reference number 43) whereby the first author's name was misspelled. The correct citation is provided below. We apologize for the inconvenience. ...

journal_title：Cell death & disease

authors： Wang LH,Baker NE

更新日期：2019-10-22 00:00:00

abstract：:The development of nephrotoxicity largely limits the clinical use of chemotherapy. MiRNAs are able to target various genes and involved in the regulation of diverse cellular processes, including cell apoptosis and death. Our study showed that miR-181a expression was significantly increased after 5-fluorouracil (5-FU) ...

journal_title：Cell death & disease

authors： Liu XY,Zhang FR,Shang JY,Liu YY,Lv XF,Yuan JN,Zhang TT,Li K,Lin XC,Liu X,Lei Q,Fu XD,Zhou JG,Liang SJ

更新日期：2018-05-23 00:00:00

abstract：:This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...

journal_title：Cell death & disease

authors： Li L,Liu J,Xu M,Yu H,Lv C,Cao F,Wang Z,Fu Y,Zhang M,Meng H,Zhang X,Kang L,Zhang Z,Li J,Feng J,Lian X,Yu L,Zhou J

更新日期：2020-03-30 00:00:00

abstract：:Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both in patients and transgenic mouse models, which prompted us to investigate whether disease-specific...

journal_title：Cell death & disease

authors： L'Episcopo F,Drouin-Ouellet J,Tirolo C,Pulvirenti A,Giugno R,Testa N,Caniglia S,Serapide MF,Cisbani G,Barker RA,Cicchetti F,Marchetti B

更新日期：2016-04-28 00:00:00

abstract：:The aim of the present report was to investigate whether, in the mammalian spinal cord, cell death induced by transient excitotoxic stress could trigger activation and proliferation of endogenous neuroprogenitor cells as a potential source of a lesion repair process and the underlying time course. Because it is diffic...

journal_title：Cell death & disease

authors： Mazzone GL,Mladinic M,Nistri A

更新日期：2013-10-31 00:00:00

abstract：:The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation. In addition, WTAP is also a regulator of the nuclear complex required for ...

journal_title：Cell death & disease

authors： Sorci M,Ianniello Z,Cruciani S,Larivera S,Ginistrelli LC,Capuano E,Marchioni M,Fazi F,Fatica A

更新日期：2018-07-23 00:00:00

abstract：:Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, B7-H4 expression in ICC and peritumoral tissues w...

journal_title：Cell death & disease

authors： Xie N,Cai JB,Zhang L,Zhang PF,Shen YH,Yang X,Lu JC,Gao DM,Kang Q,Liu LX,Zhang C,Huang XY,Zou H,Zhang XY,Song ZJ,Sun HX,Fu BM,Ke AW,Shi GM

更新日期：2017-12-13 00:00:00

abstract：:Reactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, and incr...

journal_title：Cell death & disease

authors： Livne-Bar I,Lam S,Chan D,Guo X,Askar I,Nahirnyj A,Flanagan JG,Sivak JM

更新日期：2016-09-29 00:00:00

abstract：:Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays a crucial role in mediating abnormal keratinocytes hyperproliferation. From the therapeutic perspective, the molecules with strong anti-p...

journal_title：Cell death & disease

authors： Thatikonda S,Pooladanda V,Sigalapalli DK,Godugu C

更新日期：2020-01-10 00:00:00

abstract：:Mechanisms underlying the generation of induced pluripotent stem cells (iPSC) and keeping iPSC stability remain to be further defined. Accumulated evidences showed that iPSC reprogramming may be controlled by the cell-division-rate-dependent model. Here we reported effects of absence of mouse p27 or p18 on iPSC genera...

journal_title：Cell death & disease

authors： Zhan Z,Song L,Zhang W,Gu H,Cheng H,Zhang Y,Yang Y,Ji G,Feng H,Cheng T,Li Y

更新日期：2019-03-20 00:00:00

abstract：:The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies...

journal_title：Cell death & disease

authors： Hurst S,Gonnot F,Dia M,Crola Da Silva C,Gomez L,Sheu SS

更新日期：2020-08-19 00:00:00