Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways.

abstract：:Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first ...

journal_title：Cell death & disease

authors： Bessa C,Soares J,Raimundo L,Loureiro JB,Gomes C,Reis F,Soares ML,Santos D,Dureja C,Chaudhuri SR,Lopez-Haber C,Kazanietz MG,Gonçalves J,Simões MF,Rijo P,Saraiva L

更新日期：2018-01-18 00:00:00

abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

journal_title：Cell death & disease

authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

更新日期：2020-10-14 00:00:00

abstract：:Given the dense stroma and poor vascularization, access to nutrients is limited in the microenvironment of pancreatic ductal adenocarcinoma (PDA). PDA cells can efficiently recycle various metabolic substrates through the activation of different rescuing pathways, including the autophagy pathway. However, the precise ...

journal_title：Cell death & disease

authors： Meng Q,Xu J,Liang C,Liu J,Hua J,Zhang Y,Ni Q,Shi S,Yu X

更新日期：2018-12-11 00:00:00

abstract：:Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase-dependent pathway involving cytosolic acidification and alkalinization of tumour pH. In this paper, we further investigated the mechanisms of ESOM-induc...

journal_title：Cell death & disease

authors： Marino ML,Fais S,Djavaheri-Mergny M,Villa A,Meschini S,Lozupone F,Venturi G,Della Mina P,Pattingre S,Rivoltini L,Codogno P,De Milito A

更新日期：2010-10-21 00:00:00

abstract：:The δ opioid receptor (DOR) is involved in the regulation of malignant transformation and tumor progression of hepatocellular carcinoma (HCC). However, regulation of the DOR in HCC remains poorly defined. We found that miR-874 was identified as a negative regulator of the DOR, which is a direct and functional target o...

journal_title：Cell death & disease

authors： Zhang Y,Wei Y,Li X,Liang X,Wang L,Song J,Zhang X,Zhang C,Niu J,Zhang P,Ren Z,Tang B

更新日期：2018-01-26 00:00:00

abstract：:ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple ...

journal_title：Cell death & disease

authors： Li L,Su N,Zhou T,Zheng D,Wang Z,Chen H,Yuan S,Li W

更新日期：2018-02-02 00:00:00

abstract：:Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and acquired resistance remain a ...

journal_title：Cell death & disease

authors： Eyermann CE,Haley JD,Alexandrova EM

更新日期：2021-01-26 00:00:00

abstract：:Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho GTPase-activating protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed in glioma and pancreatic ductal adenocarcinoma. The present study explored the expression in colorectal cance...

journal_title：Cell death & disease

authors： Pan S,Deng Y,Fu J,Zhang Y,Zhang Z,Ru X,Qin X

更新日期：2018-06-04 00:00:00

abstract：:The repeated treatment of cancer cells with chemo- or radiotherapy induces therapy resistance, but it was previously unknown whether the same effect occurs upon continuous exposure of cancer cells to diet-derived chemopreventive agents. We elucidated this interesting question in pancreatic ductal adenocarcinoma, which...

journal_title：Cell death & disease

authors： Fan P,Zhang Y,Liu L,Zhao Z,Yin Y,Xiao X,Bauer N,Gladkich J,Mattern J,Gao C,Schemmer P,Gross W,Herr I

更新日期：2016-06-02 00:00:00

abstract：:Intrinsic apoptosis relies on the ability of the BCL-2 family to induce the formation of pores on the outer mitochondrial membrane. Previous studies have shown that both BAX and BAK are essential during murine embryogenesis, and reports in human cancer cell lines identified non-canonical roles for BAX and BAK in mitoc...

journal_title：Cell death & disease

authors： Joshi P,Bodnya C,Rasmussen ML,Romero-Morales AI,Bright A,Gama V

更新日期：2020-09-25 00:00:00

abstract：:An increasing interest in liver cancer stemness arises owing to its aggressive behavior and poor prognosis. CD133, a widely known liver cancer stem cell marker, plays critical roles in the maintenance of liver cancer stemness. Thus, exploring the regulatory mechanism of CD133 expression is significant. In the present ...

journal_title：Cell death & disease

authors： Wang Y,Wu G,Fu X,Xu S,Wang T,Zhang Q,Yang Y

更新日期：2019-06-13 00:00:00

abstract：:Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a ...

journal_title：Cell death & disease

authors： Jeong BC,Kang IH,Hwang YC,Kim SH,Koh JT

更新日期：2014-11-20 00:00:00

abstract：:DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactivation of DDX3 leads ...

journal_title：Cell death & disease

authors： Padmanabhan PK,Zghidi-Abouzid O,Samant M,Dumas C,Aguiar BG,Estaquier J,Papadopoulou B

更新日期：2016-10-13 00:00:00

abstract：:Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca2+. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca2+ signals. MicroRNAs (miRNAs) have been reported to be potential therapeutic targets for many diseases, including breast cancer. Recently...

journal_title：Cell death & disease

authors： Pan S,Zhao X,Shao C,Fu B,Huang Y,Zhang N,Dou X,Zhang Z,Qiu Y,Wang R,Jin M,Kong D

更新日期：2021-01-04 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. The mechanisms underlying NSCLC tumorigenesis are incompletely understood. Transfer RNA (tRNA) modification is emerging as a novel regulatory mechanism for carcinogenesis. However, the role of tRNA modification in NSCLC remains obsc...

journal_title：Cell death & disease

authors： He Q,Yang L,Gao K,Ding P,Chen Q,Xiong J,Yang W,Song Y,Wang L,Wang Y,Ling L,Wu W,Yan J,Zou P,Chen Y,Zhai R

更新日期：2020-05-11 00:00:00

abstract：:Novel therapeutic targets are required to protect the heart against cell death from acute ischemia-reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysfunction and a genetic form of Parkinson's disease. Genetic ablation of DJ-1 renders the brain more susceptible...

journal_title：Cell death & disease

authors： Dongworth RK,Mukherjee UA,Hall AR,Astin R,Ong SB,Yao Z,Dyson A,Szabadkai G,Davidson SM,Yellon DM,Hausenloy DJ

更新日期：2014-02-27 00:00:00

abstract：:The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX wo...

journal_title：Cell death & disease

authors： Alexandrova EM,Xu S,Moll UM

更新日期：2017-03-16 00:00:00

abstract：:Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X7 is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+...

journal_title：Cell death & disease

authors： Ousingsawat J,Wanitchakool P,Schreiber R,Kunzelmann K

更新日期：2018-02-20 00:00:00

abstract：:The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence of KIFC1, cell cycle kinetics decrease significa...

journal_title：Cell death & disease

authors： Wei YL,Yang WX

更新日期：2019-05-24 00:00:00

abstract：:In vertebrates, mitochondria are tightly preserved energy producing organelles, which sustain nervous system development and function. The understanding of proteins that regulate their homoeostasis in complex animals is therefore critical and doing so via means of systemic analysis pivotal to inform pathophysiological...

journal_title：Cell death & disease

authors： Martín-Jiménez R,Faccenda D,Allen E,Reichel HB,Arcos L,Ferraina C,Strobbe D,Russell C,Campanella M

更新日期：2018-06-04 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with very poor prognosis. Therefore, it is important to fully understand the molecular mechanism underlying its occurrence and development. Pumilio RNA-binding family member 1 (PUM1) has been reported to function as an oncogene in ovarian cancer and nonsmall...

journal_title：Cell death & disease

authors： Dai H,Shen K,Yang Y,Su X,Luo Y,Jiang Y,Shuai L,Zheng P,Chen Z,Bie P

更新日期：2019-08-08 00:00:00

abstract：:The majority of developmentally programmed cell death (PCD) is mediated by caspase-dependent apoptosis; however, additional modalities, including autophagy-dependent cell death, have important spatiotemporally restricted functions. Autophagy involves the engulfment of cytoplasmic components in a double membrane vesicl...

journal_title：Cell death & disease

authors： Denton D,Xu T,Dayan S,Nicolson S,Kumar S

更新日期：2019-02-08 00:00:00

abstract：:Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...

journal_title：Cell death & disease

authors： Hou S,Tian T,Qi D,Sun K,Yuan Q,Wang Z,Qin Z,Wu Z,Chen Z,Zhang J

更新日期：2018-02-15 00:00:00

abstract：:Cell death plays a pivotal role in animal development and tissue homeostasis. Dysregulation of this process is associated with a wide variety of human diseases, including developmental and immunological disorders, neurodegenerative diseases and tumors. While the fundamental role of JNK pathway in cell death has been e...

journal_title：Cell death & disease

authors： Wu C,Li Z,Ding X,Guo X,Sun Y,Wang X,Hu Y,Li T,La X,Li J,Li JA,Li W,Xue L

更新日期：2019-11-26 00:00:00

abstract：:Activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) has been implicated in diverse kidney diseases, yet its in vivo significance in diabetic nephropathy (DN) is largely unknown. In the present study, we demonstrated a podocyte-specific Rac1-deficient mouse strain and showed that specific inhibition of Rac1...

journal_title：Cell death & disease

authors： Lv Z,Hu M,Fan M,Li X,Lin J,Zhen J,Wang Z,Jin H,Wang R

更新日期：2018-03-01 00:00:00

abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

journal_title：Cell death & disease

authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

更新日期：2018-09-26 00:00:00

abstract：:Mitochondrial apoptosis-inducing factor (AIF) influences the oxidative phosphorylation (OXPHOS) system and can be recruited as a mediator of cell death. Pathogenic mutations in the AIFM1 gene cause severe human diseases. Clinical manifestations include inherited peripheral neuropathies, prenatal cerebral abnormalities...

journal_title：Cell death & disease

authors： Meyer K,Buettner S,Ghezzi D,Zeviani M,Bano D,Nicotera P

更新日期：2015-07-09 00:00:00

abstract：:α-synuclein (α-syn) accumulation and aggregation is a common pathological factor found in synucleinopathies, a group of neurodegenerative disorders that includes Parkinson´s disease (PD). It has been proposed that lipid dyshomeostasis is responsible for the occurrence of PD-related processes, however, the precise role...

journal_title：Cell death & disease

authors： Alza NP,Conde MA,Scodelaro-Bilbao PG,Salvador GA

更新日期：2021-01-07 00:00:00

abstract：:The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have indicated that SLC15A3 transcripts are mainly expressed in the lymphatic system, however, its regulation and biological role in innate im...

journal_title：Cell death & disease

authors： Song F,Yi Y,Li C,Hu Y,Wang J,Smith DE,Jiang H

更新日期：2018-07-10 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00