Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation.

abstract：:Inflammation plays an important role in hypertensive cardiac injury. The endoplasmic reticulum (ER) stress pathway is involved in the inflammatory response. However, the role of ER stress in elevated angiotensin II (Ang II)-induced cardiac injury remains unclear. In this study, we investigated the role of ER stress in...

journal_title：Cell death & disease

authors： Li TT,Jia LX,Zhang WM,Li XY,Zhang J,Li YL,Li HH,Qi YF,Du J

更新日期：2016-06-09 00:00:00

abstract：:High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated...

journal_title：Cell death & disease

authors： Peng Y,Yang C,Shi X,Li L,Dong H,Liu C,Fang Z,Wang Z,Ming S,Liu M,Xie B,Gao X,Sun Y

更新日期：2019-01-15 00:00:00

abstract：:Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation. MDM2 is highly expressed in the unchallenged tubular epithelial cells and w...

journal_title：Cell death & disease

authors： Thomasova D,Ebrahim M,Fleckinger K,Li M,Molnar J,Popper B,Liapis H,Kotb AM,Siegerist F,Endlich N,Anders HJ

更新日期：2016-11-24 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:Paired-box 6 (PAX6) is an important transcription factor required for the function of human neuroectodermal epithelial tissues. Previous studies have suggested that it is also expressed in several types of tumors and has an oncogenic role. However, little is known about its role in non-small cell lung cancer (NSCLC). ...

journal_title：Cell death & disease

authors： Wu DM,Zhang T,Liu YB,Deng SH,Han R,Liu T,Li J,Xu Y

更新日期：2019-04-25 00:00:00

abstract：:STAT1, which carries tumor suppressor functions in several models, consists of two isoforms, namely STAT1α and STAT1β. The biological function and significance of STAT1β has never been examined in human cancer. We examined STAT1β function in esophageal squamous cell carcinoma (ESCC) by transfecting a STAT1β gene into ...

journal_title：Cell death & disease

authors： Zhang Y,Chen Y,Yun H,Liu Z,Su M,Lai R

更新日期：2017-10-05 00:00:00

abstract：:The incidence of malignant melanoma has continued to rise during the past decades. However, in the last few years, treatment protocols have significantly been improved thanks to a better understanding of the key oncogenes and signaling pathways involved in its pathogenesis and progression. Anticancer therapy would eit...

journal_title：Cell death & disease

authors： Mattia G,Puglisi R,Ascione B,Malorni W,Carè A,Matarrese P

更新日期：2018-01-25 00:00:00

abstract：:Mitochondrial membrane potential provides a valuable indicator of cells' health and functional status. Cytometry- and microscopy-based analyses, in combination with fluorescent probes, are widely used to study mitochondrial behavior related to cellular pathways, most notably - apoptosis. The cyanine dye JC-1 (5,5',6,6...

journal_title：Cell death & disease

authors： Perelman A,Wachtel C,Cohen M,Haupt S,Shapiro H,Tzur A

更新日期：2012-11-22 00:00:00

abstract：:The Notch cascade is a fundamental and highly conserved pathway able to control cell-fate. The Notch pathway arises from the interaction of one of the Notch receptors (Notch1-4) with different types of ligands; in particular, the Notch pathway can be activated canonically (through the ligands Jagged1, Jagged2, DLL1, D...

journal_title：Cell death & disease

authors： Fazio C,Ricciardiello L

更新日期：2016-12-08 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gastric cancer (GC) patients. Here, we have identified a novel subset of CD45+CD33lowCD11bdim MDSCs in the periphe...

journal_title：Cell death & disease

authors： Mao FY,Zhao YL,Lv YP,Teng YS,Kong H,Liu YG,Wu XL,Hao CJ,Chen W,Duan MB,Han B,Ma Q,Wang TT,Peng LS,Zhang JY,Cheng P,Su CY,Fu XL,Zou QM,Guo G,Guo XL,Zhuang Y

更新日期：2018-07-09 00:00:00

abstract：:Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 and mannose-6-phosphate (M6P)-tagged...

journal_title：Cell death & disease

authors： Takeda T,Komatsu M,Chiwaki F,Komatsuzaki R,Nakamura K,Tsuji K,Kobayashi Y,Tominaga E,Ono M,Banno K,Aoki D,Sasaki H

更新日期：2019-11-20 00:00:00

abstract：:Circular RNAs (circRNAs) have been identified play a vital role in various different types of cancer via sponging miRNAs (microRNAs). However, their role in lung adenocarcinoma (LUAD) remains largely unclear. In this study, we systematically characterized the circRNA expression profiles in the LUAD cancer tissues and ...

journal_title：Cell death & disease

authors： Wang J,Zhao X,Wang Y,Ren F,Sun D,Yan Y,Kong X,Bu J,Liu M,Xu S

更新日期：2020-01-16 00:00:00

abstract：:Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting lncRNA in numerous cancers. However, the clinical significance and biological function of TTN-AS1 in lung aden...

journal_title：Cell death & disease

authors： Jia Y,Duan Y,Liu T,Wang X,Lv W,Wang M,Wang J,Liu L

更新日期：2019-07-30 00:00:00

abstract：:The clinical use of the antineoplastic drug cisplatin is limited by its deleterious nephrotoxic side effect. Cisplatin-induced nephrotoxicity is associated with an increase in oxidative stress, leading ultimately to renal cell death and irreversible kidney dysfunction. Oxidative stress could be modified by the cystic ...

journal_title：Cell death & disease

authors： Rubera I,Duranton C,Melis N,Cougnon M,Mograbi B,Tauc M

更新日期：2013-10-03 00:00:00

abstract：:Hepatocellular carcinoma is the sixth most common cancer and gives rise to numerous deaths around the world every year. However, the molecular mechanism that controls hepatocarcinogenesis remains largely unknown. Here we found out an uncharacterized long noncoding RNA named lncAKHE. We found that lncAKHE was highly ex...

journal_title：Cell death & disease

authors： Huang G,Jiang H,Lin Y,Wu Y,Cai W,Shi B,Luo Y,Jian Z,Zhou X

更新日期：2018-05-01 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and survival of the KYSE150 and KYSE450 ESCC cell lines in a dose-dependent ...

journal_title：Cell death & disease

authors： Cao YY,Yu J,Liu TT,Yang KX,Yang LY,Chen Q,Shi F,Hao JJ,Cai Y,Wang MR,Lu WH,Zhang Y

更新日期：2018-01-16 00:00:00

abstract：:Adenanthin, a natural diterpenoid isolated from the leaves of Isodon adenanthus, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs ...

journal_title：Cell death & disease

authors： Hou JK,Huang Y,He W,Yan ZW,Fan L,Liu MH,Xiao WL,Sun HD,Chen GQ

更新日期：2014-09-04 00:00:00

abstract：:Growing evidence indicates that cell adhesion to extracellular matrix (ECM) plays an important role in cancer chemoresistance. Leukemic T cells express several adhesion receptors of the β1 integrin subfamily with which they interact with ECM. However, the role of β1 integrins in chemoresistance of T-cell acute lymphob...

journal_title：Cell death & disease

authors： Berrazouane S,Boisvert M,Salti S,Mourad W,Al-Daccak R,Barabé F,Aoudjit F

更新日期：2019-05-01 00:00:00

abstract：:Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extrac...

journal_title：Cell death & disease

authors： Cerella C,Muller F,Gaigneaux A,Radogna F,Viry E,Chateauvieux S,Dicato M,Diederich M

更新日期：2015-06-11 00:00:00

abstract：:Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence...

journal_title：Cell death & disease

authors： Zhong J,Wang H,Chen W,Sun Z,Chen J,Xu Y,Weng M,Shi Q,Ma D,Miao C

更新日期：2017-05-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...

journal_title：Cell death & disease

authors： Zhang Y,Li D,Jiang Q,Cao S,Sun H,Chai Y,Li X,Ren T,Yang R,Feng F,Li BA,Zhao Q

更新日期：2018-07-03 00:00:00

abstract：:The DEAD/DEAH box helicase 11 (DDX11) plays vital roles in regulating the initiation of DNA replication. However, its precise function and regulation in hepatocellular carcinoma (HCC) have never been reported yet. In the current study, we found that DDX11 was overexpressed in HCC tissues. High DDX11 expression was pos...

journal_title：Cell death & disease

authors： Yu Y,Zhao D,Li K,Cai Y,Xu P,Li R,Li J,Chen X,Chen P,Cui G

更新日期：2020-04-24 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...

journal_title：Cell death & disease

authors： Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

更新日期：2017-01-05 00:00:00

abstract：:Gastric cancer (GC) ranks among the top five malignant tumors worldwide by the incidence and mortality rate. However, the mechanisms underlying its progression are poorly understood. In this study, we investigated the role of SIRT1, a class III deacetylase, in the invasion and metastasis of GC. Here, we found that kno...

journal_title：Cell death & disease

authors： Dong G,Wang B,An Y,Li J,Wang X,Jia J,Yang Q

更新日期：2018-09-24 00:00:00

abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

journal_title：Cell death & disease

authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

更新日期：2018-09-26 00:00:00

abstract：:Histones and their post-translational modifications have key roles in chromatin remodeling and gene transcription. Besides intranuclear functions, histones act as damage-associated molecular pattern molecules when they are released into the extracellular space. Administration of exogenous histones to animals leads to ...

journal_title：Cell death & disease

authors： Chen R,Kang R,Fan XG,Tang D

更新日期：2014-08-14 00:00:00

abstract：:Transplantation of neural progenitors derived from human embryonic stem cells (hESCs) provides a potential therapy for ischemic stroke. However, poor graft survival within the host environment has hampered the benefits and applications of cell-based therapies. The present investigation tested a preconditioning strateg...

journal_title：Cell death & disease

authors： Francis KR,Wei L

更新日期：2010-01-01 00:00:00

abstract：:Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor micr...

journal_title：Cell death & disease

authors： Wang G,Wang Q,Liang N,Xue H,Yang T,Chen X,Qiu Z,Zeng C,Sun T,Yuan W,Liu C,Chen Z,He X

更新日期：2020-05-04 00:00:00

abstract：:Apoptosis has been established as a mechanism of anti-cancer defense. Members of the BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found to be deregulated in cancer and believed to lead to the survival of malignant clones. However, over the years, a number of studies pointed ...

journal_title：Cell death & disease

authors： Labi V,Erlacher M

更新日期：2015-03-05 00:00:00