Abstract:
:PTPL1 is a non-receptor protein tyrosine phosphatase involved in apoptosis regulation, although controversial findings have been reported in different cancer types. We report here a proapoptotic role for PTPL1 in PC3 and LNCaP prostate cancer cells, as its absence induces apoptosis resistance upon treatment with different drugs. In PC3 cells, PTPL1 silencing by small interfering RNA influences the expression levels of Bcl-xL and Mcl-1(S) proteins as well as final events in the apoptotic process such as activation of caspases and caspase-mediated cleavage of proteins like Mcl-1 or poly (ADP-ribose) polymerase. We have identified PKCδ as an intermediary of PTPL1-mediated apoptotic signalling and that phosphorylation status of NF-κB and IκBα is influenced by PTPL1 and PKCδ. Furthermore, the loss of PTPL1 and PKCδ expression in poorly differentiated, more aggressive human prostate cancers also indicate that their absence could be related to apoptosis resistance and tumour progression.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Castilla C,Chinchón D,Medina R,Torrubia FJ,Japón MA,Sáez Cdoi
10.1038/cddis.2013.90subject
Has Abstractpub_date
2013-04-04 00:00:00pages
e576issn
2041-4889pii
cddis201390journal_volume
4pub_type
杂志文章abstract::We previously showed that mice with knockout of Cytl1, a functionally uncharacterized cytokine candidate, exhibit normal endochondral ossification and long-bone development. Here, we investigated the potential functions of CYTL1 in bone homeostasis. We found that Cytl1-/- mice exhibited higher bone mass than wild-type...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1284-4
更新日期:2019-01-18 00:00:00
abstract::The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington's disease (HD), a neurodegenerative disorder caused by neural death due to expa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02754-w
更新日期:2020-07-18 00:00:00
abstract::Cervical cancer is the most common gynecological malignancy in the world; however, the survival rates of advanced-stage and recurrent cervical cancer patients remain poor. The multifaced protein insulin-like growth factor 2 receptor (IGF2R) has various ligands, represented as IGF-2 and mannose-6-phosphate (M6P)-tagged...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2117-9
更新日期:2019-11-20 00:00:00
abstract::HOXA5 is considered a regulator involved in embryonic development and cellular differentiation and a tumor suppressor. Nevertheless, its biological role in cervical carcinoma is still unclear. In the present study, immunohistochemistry showed that HOXA5 expression gradually decreased as the degree of cervical lesions ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2629-3
更新日期:2020-06-04 00:00:00
abstract::Drug resistance is one of the major hurdles for cancer treatment. However, the underlying mechanisms are still largely unknown and therapeutic options remain limited. In this study, we show that microRNA (miR)-587 confers resistance to 5-fluorouracil (5-FU)-induced apoptosis in vitro and reduces the potency of 5-FU in...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.200
更新日期:2015-08-06 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particular...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.153
更新日期:2012-10-18 00:00:00
abstract::Novel therapeutic targets are required to protect the heart against cell death from acute ischemia-reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysfunction and a genetic form of Parkinson's disease. Genetic ablation of DJ-1 renders the brain more susceptible...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.41
更新日期:2014-02-27 00:00:00
abstract::Erwinia asparaginase, a bacteria-derived enzyme drug, has been used in the treatment of various cancers, especially acute lymphoblastic leukemia (ALL). One of the most significant side effects associated with asparaginase administration is immune suppression, which limits its application in clinic. Macrophages are pha...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.144
更新日期:2017-03-30 00:00:00
abstract::Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still controversial and th...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2064-5
更新日期:2019-10-28 00:00:00
abstract::The NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome is a multi-protein complex, aimed at producing IL-1β in response to danger signals which must be tightly regulated. Here we investigated the importance of the stress sensor, Heat Shock Protein 70 (HSP70) on NLRP3 inflammasome activation. H...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1491-7
更新日期:2019-03-15 00:00:00
abstract::SHP2 participates in multiple signaling events by mediating T-cell development and function, and regulates cytokine-dependent granulopoiesis. To explore whether and how SHP2 can regulate bone-marrow eosinophil differentiation, we investigate the contribution of SHP2 in the bone-marrow eosinophil development in allergi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.74
更新日期:2016-04-07 00:00:00
abstract::The mechanism of pathological osteogenesis in Ankylosing spondylitis (AS) is largely unknown. Our previous studies demonstrated that the imbalance between BMP-2 and Noggin secretion induces abnormal osteogenic differentiation of marrow-derived mesenchymal stem cells (MSCs) from AS patients in a two-dimensional culture...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1586-1
更新日期:2019-04-25 00:00:00
abstract::Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.565
更新日期:2017-10-26 00:00:00
abstract::Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical tr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.355
更新日期:2017-08-03 00:00:00
abstract::HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (Exp-t) pathway sugg...
journal_title:Cell death & disease
pub_type: 杂志文章,收录出版
doi:10.1038/cddis.2012.32
更新日期:2012-04-05 00:00:00
abstract::This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2388-1
更新日期:2020-03-30 00:00:00
abstract::Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0126-0
更新日期:2018-02-02 00:00:00
abstract::Numerous findings have demonstrated that long noncoding RNA (lncRNA) dysregulation plays a key role in many human neoplasms, including tongue squamous cell carcinoma (TSCC), yet the potential mechanisms of lncRNAs in chemo-resistance remain elusive. Our research showed that the lncRNA KCNQ1OT1 was upregulated in chemo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0793-5
更新日期:2018-07-03 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03054-z
更新日期:2020-10-14 00:00:00
abstract::Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the molecular mechanism of that remains unclear. On the basi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.65
更新日期:2013-03-14 00:00:00
abstract::KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2671-1
更新日期:2020-06-16 00:00:00
abstract::Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activated state altering their transcriptional profile, transforming their m...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03084-7
更新日期:2020-10-23 00:00:00
abstract::The high resistance against current therapies found in non-small-cell lung cancer (NSCLC) has been associated to cancer stem-like cells (CSCs), a population for which the identification of targets and biomarkers is still under development. In this study, primary cultures from early-stage NSCLC patients were establishe...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1898-1
更新日期:2019-09-10 00:00:00
abstract::Advanced glycation end products (AGEs) can stimulate osteoblast apoptosis and have a critical role in the pathophysiology of diabetic osteoporosis. Mitochondrial abnormalities are closely related to osteoblast dysfunction. However, it remains unclear whether mitochondrial abnormalities are involved in AGE-induced oste...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0718-3
更新日期:2018-06-04 00:00:00
abstract::The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast cancer samples, could promote cell proliferation and tumorigenesis. However, whether TSP50 also has a key role i...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.61
更新日期:2015-03-26 00:00:00
abstract::Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8+ cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OVA-specific CD8+ CTLs ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0665-z
更新日期:2018-05-24 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote metastasis. There is evidence that microRNAs (miRNAs) may play a role in...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0628-4
更新日期:2018-05-29 00:00:00
abstract::Melatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0083-7
更新日期:2018-01-19 00:00:00
abstract::Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. In this paper, we report the production of mammospheres from three lines of TNBC cells and demonstrate that both parthenolide (PN) and its soluble analog dimethylaminoparthenolide (DMAPT) suppress...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.94
更新日期:2016-04-14 00:00:00
abstract::We demonstrate that EphB3 receptors mediate oligodendrocyte (OL) cell death in the injured spinal cord through dependence receptor mechanism. OLs in the adult spinal cord express EphB3 as well as other members of the Eph receptor family. Spinal cord injury (SCI) is associated with tissue damage, cellular loss and dist...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.262
更新日期:2015-10-15 00:00:00