Mitochondrial ferritin protects the murine myocardium from acute exhaustive exercise injury.

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA against CRC cells was little reported. Here, we proved that BA elicited CRC cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, BA treatment induced autophagy via inhibiting the...

journal_title：Cell death & disease

authors： Wang S,Wang K,Zhang C,Zhang W,Xu Q,Wang Y,Zhang Y,Li Y,Zhang Y,Zhu H,Song F,Lei Y,Bu Y

更新日期：2017-10-05 00:00:00

abstract：:Pathological retinal neovascularization is the most common cause of vision loss. PKCθ has been shown to play a role in type 2 diabetes, which is linked to retinal neovascularization. Based on these clues, we have studied the role of PKCθ and its downstream target genes JunB and VEGFR3 in retinal neovascularization usi...

journal_title：Cell death & disease

authors： Kumar R,Mani AM,Singh NK,Rao GN

更新日期：2020-05-07 00:00:00

abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

journal_title：Cell death & disease

authors： Badley AD,Sainski A,Wightman F,Lewin SR

更新日期：2013-07-11 00:00:00

abstract：:Catecholaminergic Polymorphic Ventricular Tachycardia type 2 (CPVT2) is a highly lethal recessive arrhythmogenic disease caused by mutations in the calsequestrin-2 (CASQ2) gene. We have previously demonstrated that viral transfer of the wild-type (WT) CASQ2 gene prevents the development of CPVT2 in a genetically induc...

journal_title：Cell death & disease

authors： Lodola F,Morone D,Denegri M,Bongianino R,Nakahama H,Rutigliano L,Gosetti R,Rizzo G,Vollero A,Buonocore M,Napolitano C,Condorelli G,Priori SG,Di Pasquale E

更新日期：2016-10-06 00:00:00

abstract：:Aberrantly expressed miRNAs play a crucial role in the development of multiple cancer types, including chordoma. However, the detailed molecular mechanisms are unclear and need to be elucidated. In this study, miRNAs were screened by miRNA array analysis and then confirmed by real-time PCR analysis. We found that miR-...

journal_title：Cell death & disease

authors： Zhang H,Yang K,Ren T,Huang Y,Tang X,Guo W

更新日期：2018-06-07 00:00:00

abstract：:Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca(2+)-dependent phosphatidylserine exposure and is defective in patients with Scott syndrome, a rare bleeding disorder. Ano6 may also form Cl(-) channels...

journal_title：Cell death & disease

authors： Harper MT,Poole AW

更新日期：2013-12-19 00:00:00

abstract：:We investigated the mechanism underlying the effect of a combination treatment of 125I radioactive seed implantation and lobaplatin (LBP) in hepatocellular carcinoma. The effects of administration of HCC cells and subcutaneous tumor model of mice with different doses of 125I or a sensitizing concentration of LBP alone...

journal_title：Cell death & disease

authors： Li D,Wang WJ,Wang YZ,Wang YB,Li YL

更新日期：2019-10-03 00:00:00

abstract：:Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently ...

journal_title：Cell death & disease

authors： Luo W,Wu H,Ye Y,Li Z,Hao S,Kong L,Zheng X,Lin S,Nie Q,Zhang X

更新日期：2014-07-17 00:00:00

abstract：:miRNA let-7e is involved in stem cell differentiation, and metalloproteinases are among its potential target genes. We hypothesized that the inhibitory action of let-7e on regulation of MMP9 expression could represent a crucial mechanism during differentiation of adipose-derived stem cells (ASCs). ASCs were differenti...

journal_title：Cell death & disease

authors： Ventayol M,Viñas JL,Sola A,Jung M,Brüne B,Pi F,Mastora C,Hotter G

更新日期：2014-02-06 00:00:00

abstract：:Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely on use of animal models because culture systems do not faithfully mimic human intestinal physiology. Here we used a human Gut-on-a-Chip (Gut Chip) microfluidic device lined by human intestinal epithelial cells and vascular endoth...

journal_title：Cell death & disease

authors： Jalili-Firoozinezhad S,Prantil-Baun R,Jiang A,Potla R,Mammoto T,Weaver JC,Ferrante TC,Kim HJ,Cabral JMS,Levy O,Ingber DE

更新日期：2018-02-14 00:00:00

abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

journal_title：Cell death & disease

authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

更新日期：2017-06-29 00:00:00

abstract：:Reactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, and incr...

journal_title：Cell death & disease

authors： Livne-Bar I,Lam S,Chan D,Guo X,Askar I,Nahirnyj A,Flanagan JG,Sivak JM

更新日期：2016-09-29 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. In this paper, we report the production of mammospheres from three lines of TNBC cells and demonstrate that both parthenolide (PN) and its soluble analog dimethylaminoparthenolide (DMAPT) suppress...

journal_title：Cell death & disease

authors： Carlisi D,Buttitta G,Di Fiore R,Scerri C,Drago-Ferrante R,Vento R,Tesoriere G

更新日期：2016-04-14 00:00:00

abstract：:N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of cancer stem cells (CSCs) remains poorly understood. In this stud...

journal_title：Cell death & disease

authors： Feng X,Xu X,Xiao X,Zou K,Yu W,Wu J,Tang R,Gao Y,Hao J,Zhao X,Liao Y,Chen Y,Huang W,Guo W,Kang L,Deng W

更新日期：2017-05-11 00:00:00

abstract：:Therapeutic resistance of neoplasms is mainly attributed to gradual evolution of mutational profile1. Here, we demonstrate a microRNA-mediated mechanism that effectively improves fitness of SKBR3 mammary carcinoma cells by cytoplasmic reprogramming. The reprogramming is triggered by endogenous miR4673 transcribed from...

journal_title：Cell death & disease

authors： Dökümcü K,Simonian M,Farahani RM

更新日期：2018-10-19 00:00:00

abstract：:Emerging evidence suggests that long noncoding RNA (lncRNA) plays pivotal roles in regulating various biological process in human cancers. Titin-antisense RNA1 (TTN-AS1) has been regarded as a tumor promoting lncRNA in numerous cancers. However, the clinical significance and biological function of TTN-AS1 in lung aden...

journal_title：Cell death & disease

authors： Jia Y,Duan Y,Liu T,Wang X,Lv W,Wang M,Wang J,Liu L

更新日期：2019-07-30 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic (DA) neurons in the substantia nigra (SN); however, the underlying molecular mechanisms remain to be fully elucidated. In this study, we found that the expression level of transcription factor Six...

journal_title：Cell death & disease

authors： Gao J,Kang XY,Sun S,Li L,Zhang BL,Li YQ,Gao DS

更新日期：2016-05-05 00:00:00

abstract：:Epigenetic alteration of tumor suppression gene is one of the most significant indicators in human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel ESCC hypermethylation biomarker ZNF132 by integrative computational analysis to comprehensive genome-wide DNA methylation microarray dataset...

journal_title：Cell death & disease

authors： Jiang D,He Z,Wang C,Zhou Y,Li F,Pu W,Zhang X,Feng X,Zhang M,Yecheng X,Xu Y,Jin L,Guo S,Wang J,Wang M

更新日期：2018-12-18 00:00:00

abstract：:ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechan...

journal_title：Cell death & disease

authors： Chen Z,Wu C,Liu Y,Li H,Zhu Y,Huang C,Lin H,Qiao Q,Huang M,Zhu Q,Wang L

更新日期：2020-08-22 00:00:00

abstract：:The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause ma...

journal_title：Cell death & disease

authors： Guo Z,Song J,Hao J,Zhao H,Du X,Li E,Kuang Y,Yang F,Wang W,Deng J,Wang Q

更新日期：2019-05-16 00:00:00

abstract：:Mitogen-activated protein kinase kinase 3 (MAP2K3, MKK3) is a member of the dual specificity protein kinase group that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic or stress-inducing stimuli and participates in the MAP kinase-mediated signaling cascade, leading to cell proliferation a...

journal_title：Cell death & disease

authors： Baldari S,Ubertini V,Garufi A,D'Orazi G,Bossi G

更新日期：2015-01-29 00:00:00

abstract：:Calcineurin signalling plays a critical role in the pathogenesis of many cardiovascular diseases. Calcineurin has been proven to affect a series of signalling pathways and to exert a proapoptotic effect in cardiomyocytes. However, whether it is able to regulate autophagy remains largely unknown. Here, we report that p...

journal_title：Cell death & disease

authors： He H,Liu X,Lv L,Liang H,Leng B,Zhao D,Zhang Y,Du Z,Chen X,Li S,Lu Y,Shan H

更新日期：2014-01-16 00:00:00

abstract：:Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional treatment associating surgical resection and subsequent radio-chemotherapy. Among these heterogeneous tumors, a subpopulation of chemo- and radioresistant GBM stem-like cells appears to be involved in the systematic GBM recurrence. Moreover...

journal_title：Cell death & disease

authors： Dahan P,Martinez Gala J,Delmas C,Monferran S,Malric L,Zentkowski D,Lubrano V,Toulas C,Cohen-Jonathan Moyal E,Lemarie A

更新日期：2014-11-27 00:00:00

abstract：:The homolog of p53 gene, p63, encodes multiple p63 protein isoforms. TAp63 proteins contain an N-terminal transactivation domain similar to that of p53 and function as tumor suppressors; whereas ΔNp63 isoforms, which lack the intact N-terminal transactivation domain, are associated with human tumorigenesis. Accumulati...

journal_title：Cell death & disease

authors： Li C,Chang DL,Yang Z,Qi J,Liu R,He H,Li D,Xiao ZX

更新日期：2013-12-05 00:00:00

abstract：:Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular target of GCs are monocytes/macrophages. The role of GCs in monocyte survival is also debated. Although both granulocyte macrophage-colony stimulating factor (GM-CSF) and macrophage-CSF (M-...

journal_title：Cell death & disease

authors： Achuthan A,Aslam ASM,Nguyen Q,Lam PY,Fleetwood AJ,Frye AT,Louis C,Lee MC,Smith JE,Cook AD,Olshansky M,Turner SJ,Hamilton JA

更新日期：2018-02-15 00:00:00

abstract：:Drug resistance is a major problem in cancer therapy. A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells. We examined the effect of primary human CAFs on p53 induction and cell viability in prostate cance...

journal_title：Cell death & disease

authors： Cheteh EH,Augsten M,Rundqvist H,Bianchi J,Sarne V,Egevad L,Bykov VJ,Östman A,Wiman KG

更新日期：2017-06-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) are resistant to TNFα-induced apoptosis and blockade of TNFα-induced NF-κB activation sensitizes glioma cells to apoptosis. As Casein kinase-2 (CK2) induces aberrant NF-κB activation and as we observed elevated CK2 levels in GBM tumors, we investigated the potential of CK2 inhibitors (CK2...

journal_title：Cell death & disease

authors： Dixit D,Sharma V,Ghosh S,Mehta VS,Sen E

更新日期：2012-02-09 00:00:00

abstract：:Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of ...

journal_title：Cell death & disease

authors： Li J,Xu X,Meng S,Liang Z,Wang X,Xu M,Wang S,Li S,Zhu Y,Xie B,Lin Y,Zheng X,Liu B,Xie L

更新日期：2017-08-24 00:00:00

abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

journal_title：Cell death & disease

authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

更新日期：2013-09-12 00:00:00