Transcription factor Six2 mediates the protection of GDNF on 6-OHDA lesioned dopaminergic neurons by regulating Smurf1 expression.

abstract：:We reported previously that adult (HRAS-/-; NRAS-/-) double knockout (DKO) mice showed no obvious external phenotype although lower-than-expected numbers of weaned DKO animals were consistently tallied after crossing NRAS-KO and HRAS-KO mice kept on mixed genetic backgrounds. Using mouse strains kept on pure C57Bl/6 b...

journal_title：Cell death & disease

authors： Fuentes-Mateos R,Jimeno D,Gómez C,Calzada N,Fernández-Medarde A,Santos E

更新日期：2019-11-04 00:00:00

abstract：:Histamine is a widely distributed biogenic amine involved in the regulation of an array of biological processes. Serum histamine level is markedly elevated in the early stages of acute myocardial infarction, whereas the role it plays remains unclear. Histidine decarboxylase (HDC) is the unique enzyme responsible for h...

journal_title：Cell death & disease

authors： Ding S,Abudupataer M,Zhou Z,Chen J,Li H,Xu L,Zhang W,Zhang S,Zou Y,Hong T,Wang TC,Yang X,Ge J

更新日期：2018-06-07 00:00:00

abstract：:Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has ...

journal_title：Cell death & disease

authors： Vasileva EA,Shuvalov OU,Garabadgiu AV,Melino G,Barlev NA

更新日期：2015-07-23 00:00:00

abstract：:Transient receptor potential vanilloid type 4 (TRPV4) is a Ca2+-permeable cation channel that is known to be an osmosensor and thermosensor. Currently, limited evidence shows that TRPV4 plays opposite roles in either promoting or inhibiting cancer development in different cancer types. Furthermore, the precise biologi...

journal_title：Cell death & disease

authors： Liu X,Zhang P,Xie C,Sham KWY,Ng SSM,Chen Y,Cheng CHK

更新日期：2019-06-12 00:00:00

abstract：:Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche generated by the presence of anti-neurogenic signals, which impa...

journal_title：Cell death & disease

authors： Domínguez-García S,Geribaldi-Doldán N,Gómez-Oliva R,Ruiz FA,Carrascal L,Bolívar J,Verástegui C,Garcia-Alloza M,Macías-Sánchez AJ,Hernández-Galán R,Nunez-Abades P,Castro C

更新日期：2020-04-22 00:00:00

abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

journal_title：Cell death & disease

authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

更新日期：2013-09-12 00:00:00

abstract：:The reduced iron usage induced by the suppression of erythropoiesis is a major cause of the systemic iron overload in CBS knockout (CBS-/-) mice. However, the relevant mechanisms are unknown. Here, we examined changes in granulocyte/erythroid cell ratios, iron content, and expression of iron-metabolism proteins, inclu...

journal_title：Cell death & disease

authors： Zhao P,Qian C,Chen YJ,Sheng Y,Ke Y,Qian ZM

更新日期：2019-09-24 00:00:00

abstract：:Alternatively activated macrophages have been reported to be helpful to alleviate systematic lupus erythematosus (SLE), and azithromycin could serve as an immunomodulator by promoting alternatively activated macrophage phenotype. However, the effect of azithromycin in SLE and the involved mechanism remain undetermined...

journal_title：Cell death & disease

authors： Wang J,Xie L,Wang S,Lin J,Liang J,Xu J

更新日期：2018-10-22 00:00:00

abstract：:Emerging evidence has shown that the PIM serine/threonine kinase family, including PIM1, PIM2 and PIM3, is associated with tumour progression towards metastasis. PIM1, an attractive molecular target, has been identified as a potential prognostic biomarker for haematological and epithelial malignancies. However, to dat...

journal_title：Cell death & disease

authors： Zhao B,Liu L,Mao J,Zhang Z,Wang Q,Li Q

更新日期：2018-02-22 00:00:00

abstract：:Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular carcinoma (HCC) is still not fully understood. In this study, we aimed to investigate the expression pattern and function roles of SPATS2 i...

journal_title：Cell death & disease

authors： Dong G,Zhang S,Shen S,Sun L,Wang X,Wang H,Wu J,Liu T,Wang C,Wang H,Lu T,Rao B,Ren Z

更新日期：2020-10-09 00:00:00

abstract：:Renal tubular cell death is the key factor of the pathogenesis of ischemia/reperfusion (I/R) kidney injury. Ferroptosis is a type of regulated cell death (RCD) found in various diseases. However, the underlying molecular mechanisms related to ferroptosis in renal I/R injury remain unclear. In the present study, we inv...

journal_title：Cell death & disease

authors： Ding C,Ding X,Zheng J,Wang B,Li Y,Xiang H,Dou M,Qiao Y,Tian P,Xue W

更新日期：2020-10-28 00:00:00

abstract：:The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...

journal_title：Cell death & disease

authors： Li M,Han Y,Zhou H,Li X,Lin C,Zhang E,Chi X,Hu J,Xu H

更新日期：2018-01-24 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:During reproductive life, the mammary epithelium undergoes consecutive cycles of proliferation, differentiation and apoptosis. Doing so relies on the retained proliferative capacity, prolonged lifespan and developmental potency of mammary stem cells (MaSCs). ΔNp63α, the predominant TP63 isoform in mammary epithelia, i...

journal_title：Cell death & disease

authors： DeCastro AJ,Dunphy KA,Hutchinson J,Balboni AL,Cherukuri P,Jerry DJ,DiRenzo J

更新日期：2013-02-28 00:00:00

abstract：:Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that treatment with a selective TRPV4 antagonist HC-067047 significantly reduced infarct size, decreased troponin T levels and improved cardiac...

journal_title：Cell death & disease

authors： Wu QF,Qian C,Zhao N,Dong Q,Li J,Wang BB,Chen L,Yu L,Han B,Du YM,Liao YH

更新日期：2017-05-25 00:00:00

abstract：:Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective. The cyclin-dependent kinase 4/6-retinoblastoma protein (CDK4/6-Rb) pathway of cell cycle contr...

journal_title：Cell death & disease

authors： Li X,Seebacher NA,Garbutt C,Ma H,Gao P,Xiao T,Hornicek FJ,Duan Z

更新日期：2018-05-01 00:00:00

abstract：:Abdominal Aortic aneurysm (AAA) is associated with chronic inflammation, cells apoptosis, and impairment of autophagy. BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-κB, as well as regulate autophagy. However, its...

journal_title：Cell death & disease

authors： Wu QY,Cheng Z,Zhou YZ,Zhao Y,Li JM,Zhou XM,Peng HL,Zhang GS,Liao XB,Fu XM

更新日期：2020-02-18 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...

journal_title：Cell death & disease

authors： Gatta V,D'Aurora M,Granzotto A,Stuppia L,Sensi SL

更新日期：2014-02-13 00:00:00

abstract：:Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axon...

journal_title：Cell death & disease

authors： Catenaccio A,Llavero Hurtado M,Diaz P,Lamont DJ,Wishart TM,Court FA

更新日期：2017-11-09 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most common malignancy of the biliary tract characterized by its high chemoresistant tendency. Although great progresses have been made in recent decades for treating many cancers with anticancer drugs, effective therapeutics methods for anti-GBC are still lacking. Therefore, inv...

journal_title：Cell death & disease

authors： Wang H,Zhan M,Xu SW,Chen W,Long MM,Shi YH,Liu Q,Mohan M,Wang J

更新日期：2017-05-11 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:Heme oxygenase-1 (HO-1), an inducible enzyme up-regulated in Alzheimer's disease, catabolises heme to biliverdin, Fe2+ and carbon monoxide (CO). CO can protect neurones from oxidative stress-induced apoptosis by inhibiting Kv2.1 channels, which mediates cellular K+ efflux as an early step in the apoptotic cascade. Sin...

journal_title：Cell death & disease

authors： Hettiarachchi N,Dallas M,Al-Owais M,Griffiths H,Hooper N,Scragg J,Boyle J,Peers C

更新日期：2014-12-11 00:00:00

abstract：:Pluripotency makes human pluripotent stem cells (hPSCs) promising for regenerative medicine, but the teratoma formation has been considered to be a major obstacle for their clinical applications. Here, we determined that the downregulation of miR-302 suppresses the teratoma formation, hampers the self-renewal and plur...

journal_title：Cell death & disease

authors： Li HL,Wei JF,Fan LY,Wang SH,Zhu L,Li TP,Lin G,Sun Y,Sun ZJ,Ding J,Liang XL,Li J,Han Q,Zhao RC

更新日期：2016-01-28 00:00:00

abstract：:The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative breast cancer (TNBC), and pharmacologic inhibition of these aberrations has shown activity in TNBC patients. Here, we designed and identified a small-molecule Comp34 that suppresses both AKT a...

journal_title：Cell death & disease

authors： Hao Q,Wang P,Dutta P,Chung S,Li Q,Wang K,Li J,Cao W,Deng W,Geng Q,Schrode K,Shaheen M,Wu K,Zhu D,Chen QH,Chen G,Elshimali Y,Vadgama J,Wu Y

更新日期：2020-12-11 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the greatest life threats for Chinese people, and the prognosis of this malignancy is poor due to the strong chemotherapy resistance in patients. Notch pathway components mediate cell survival and epithelial-mesenchymal transition (EMT), and also participate in the induction of...

journal_title：Cell death & disease

authors： Zhang Y,Li D,Jiang Q,Cao S,Sun H,Chai Y,Li X,Ren T,Yang R,Feng F,Li BA,Zhao Q

更新日期：2018-07-03 00:00:00

abstract：:In this study, the roles of p53 in impaired spermatogenic male germ cells of p53-deficient medaka were investigated by analyzing histological changes, and gene expressions of 42Sp50, Oct 4 and vitellogenin (VTG2) by RT-PCR or in situ hybridization in the testes. We found that a small number of oocyte-like cells (testi...

journal_title：Cell death & disease

authors： Yasuda T,Oda S,Li Z,Kimori Y,Kamei Y,Ishikawa T,Todo T,Mitani H

更新日期：2012-10-04 00:00:00

abstract：:The adaptation of mitochondrial homeostasis to ischemic injury is not fully understood. Here, we studied the role of dynamin-related protein 1 (Drp1) in this process. We found that mitochondrial morphology was altered in the early stage of ischemic injury while mitochondrial dysfunction occurred in the late stage of i...

journal_title：Cell death & disease

authors： Duan C,Kuang L,Xiang X,Zhang J,Zhu Y,Wu Y,Yan Q,Liu L,Li T

更新日期：2020-04-20 00:00:00

abstract：:Previous studies have shown that miR-203 is a skin-specific microRNA (miRNA) with a profound role in skin cell differentiation. However, emerging microarray and deep sequencing data revealed that miR-203 is also expressed in embryonic skeletal muscle and myoblasts. In this study, we found that miR-203 was transiently ...

journal_title：Cell death & disease

authors： Luo W,Wu H,Ye Y,Li Z,Hao S,Kong L,Zheng X,Lin S,Nie Q,Zhang X

更新日期：2014-07-17 00:00:00

abstract：:α-synuclein (α-syn) accumulation and aggregation is a common pathological factor found in synucleinopathies, a group of neurodegenerative disorders that includes Parkinson´s disease (PD). It has been proposed that lipid dyshomeostasis is responsible for the occurrence of PD-related processes, however, the precise role...

journal_title：Cell death & disease

authors： Alza NP,Conde MA,Scodelaro-Bilbao PG,Salvador GA

更新日期：2021-01-07 00:00:00