Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

abstract：:Aneuploidy including trisomy results in developmental disabilities and is the leading cause of miscarriages in humans. Unlike trisomy 21, pathogenic mechanisms of trisomy 18 remain unclear. Here, we successfully generated induced pluripotent stem cells (iPSCs) from human amniotic fluid cells (AFCs) with trisomy 18 pre...

journal_title：Cell death & disease

authors： Li T,Zhao H,Han X,Yao J,Zhang L,Guo Y,Shao Z,Jin Y,Lai D

更新日期：2017-10-26 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabine resistance...

journal_title：Cell death & disease

authors： Wei L,Ye H,Li G,Lu Y,Zhou Q,Zheng S,Lin Q,Liu Y,Li Z,Chen R

更新日期：2018-10-18 00:00:00

abstract：:Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated ...

journal_title：Cell death & disease

authors： Yuan B,Zhou XM,You ZQ,Xu WD,Fan JM,Chen SJ,Han YL,Wu Q,Zhang X

更新日期：2020-01-30 00:00:00

abstract：:Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...

journal_title：Cell death & disease

authors： Zhao K,Hao H,Liu J,Tong C,Cheng Y,Xie Z,Zang L,Mu Y,Han W

更新日期：2015-09-17 00:00:00

abstract：:Melanoma is a kind of tumor that originates from melanocytes and is characterized by chemoresistance and distant metastasis. Although the complete pathogenesis of melanoma remains unclear, increasing evidence suggests that circular RNAs (circRNAs) may be involved. In the present study, we identified a circular RNA, ci...

journal_title：Cell death & disease

authors： Qian P,Linbo L,Xiaomei Z,Hui P

更新日期：2020-04-23 00:00:00

abstract：:Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population within the tumor-driving therapy resistance and recurrence. While temozolomide (TMZ), an alkylating agent, constitutes the first-line chemother...

journal_title：Cell death & disease

authors： Mazor G,Levin L,Picard D,Ahmadov U,Carén H,Borkhardt A,Reifenberger G,Leprivier G,Remke M,Rotblat B

更新日期：2019-03-13 00:00:00

abstract：:Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferat...

journal_title：Cell death & disease

authors： Guo X,Zhu Y,Hong X,Zhang M,Qiu X,Wang Z,Qi Z,Hong X

更新日期：2017-07-27 00:00:00

abstract：:During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS. Reserve i...

journal_title：Cell death & disease

authors： Chen F,Zhang Y,Hu S,Shi X,Wang Z,Deng Z,Lin L,Zhang J,Pan Y,Bai Y,Liu F,Zhang H,Shao C

更新日期：2020-07-06 00:00:00

abstract：:Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ enhances autophagy...

journal_title：Cell death & disease

authors： He Z,Yang Y,Xing Z,Zuo Z,Wang R,Gu H,Qi F,Yao Z

更新日期：2020-06-08 00:00:00

abstract：:Osteoclasts are absorptive cells that play a critical role in homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role of epigenetic regulation in osteoclastogenesis. In this study, we investigated the role of DOT1L, which regulates gene expression epigenetically by hi...

journal_title：Cell death & disease

authors： Gao Y,Ge W

更新日期：2018-01-18 00:00:00

abstract：:Wnt signaling pathways are a highly conserved pathway, which plays an important role from the embryonic development to bone formation. The effect of Wnt pathway on osteogenesis relies on their cellular environment and the expression of target genes. However, the molecular mechanism of that remains unclear. On the basi...

journal_title：Cell death & disease

authors： Liu W,Liu Y,Guo T,Hu C,Luo H,Zhang L,Shi S,Cai T,Ding Y,Jin Y

更新日期：2013-03-14 00:00:00

abstract：:SOX4, a member of the SOX (sex-determining region Y-related HMG box) transcription factor family, has been reported to be abnormally expressed in a wide variety of cancers, and to exert a pleiotropic function. However, its function in progression of cervical cancer (CC) remains unknown. In this study, we found that SO...

journal_title：Cell death & disease

authors： Sun R,Jiang B,Qi H,Zhang X,Yang J,Duan J,Li Y,Li G

更新日期：2015-11-19 00:00:00

abstract：:WD repeat protein 79 (WDR79) is a member of the WD-repeat protein family and functions as a scaffold protein during telomerase assembly, Cajal body formation and DNA double strand break repair. We have previously shown that WDR79 is frequently overexpressed in cell lines and tissues derived from non-small cell lung ca...

journal_title：Cell death & disease

authors： Sun Y,Cao L,Sheng X,Chen J,Zhou Y,Yang C,Deng T,Ma H,Feng P,Liu J,Tan W,Ye M

更新日期：2017-04-13 00:00:00

abstract：:Proinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase tumor progression l...

journal_title：Cell death & disease

authors： Varin EM,Wojtusciszyn A,Broca C,Muller D,Ravier MA,Ceppo F,Renard E,Tanti JF,Dalle S

更新日期：2016-01-21 00:00:00

abstract：:The acquisition of MDR1-mediated chemoresistance poses a major obstacle to the success of conventional chemotherapeutic agents. HSF1 is also involved in chemoresistance, and several studies have demonstrated the relationship between HSF1 and MDR1 but without any consistent results. Paclitaxel- and doxorubicin-resistan...

journal_title：Cell death & disease

authors： Mun GI,Choi E,Lee Y,Lee YS

更新日期：2020-05-26 00:00:00

abstract：:The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as well as solid tumors, but shows dose-dependent potentially life-threatening toxicities and can induce secondary malignancies. Thus, the clinical utility of CTX wo...

journal_title：Cell death & disease

authors： Alexandrova EM,Xu S,Moll UM

更新日期：2017-03-16 00:00:00

abstract：:Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA1). Additionally, a...

journal_title：Cell death & disease

authors： Ninoyu Y,Sakaguchi H,Lin C,Suzuki T,Hirano S,Hisa Y,Saito N,Ueyama T

更新日期：2020-07-16 00:00:00

abstract：:The injurious consequences of ionizing radiation (IR) to normal human cells and the acquired radioresistance of cancer cells represent limitations to cancer radiotherapy. IR induces DNA damage response pathways that orchestrate cell cycle arrest, DNA repair or apoptosis such that irradiated cells are either repaired o...

journal_title：Cell death & disease

authors： Kumar A,Oskouian B,Fyrst H,Zhang M,Paris F,Saba JD

更新日期：2011-02-10 00:00:00

abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

journal_title：Cell death & disease

authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

更新日期：2013-09-12 00:00:00

abstract：:Back pain is a leading cause of global disability and is strongly associated with intervertebral disc (IVD) degeneration (IDD). Hallmarks of IDD include progressive cell loss and matrix degradation. The Akt signaling pathway regulates cellularity and matrix production in IVDs and its inactivation is known to contribut...

journal_title：Cell death & disease

authors： Zhang C,Smith MP,Zhou GK,Lai A,Hoy RC,Mroz V,Torre OM,Laudier DM,Bradley EW,Westendorf JJ,Iatridis JC,Illien-Jünger S

更新日期：2019-10-03 00:00:00

abstract：:The original version of this Article contained an error in Fig. 1, in which a number of incorrect fluorescence images were inadvertently incorporated into the panel. This has been corrected in both the PDF and HTML versions of the Article. ...

journal_title：Cell death & disease

authors： Jones VC,Atkinson-Dell R,Verkhratsky A,Mohamet L

更新日期：2019-03-12 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of cancer stem cell (CSC) markers, and high ALDH1 expression has been related to drug resistance and facilitated tumor growth. In this study, we investigated the potential involvement of nuclear factor erythroid 2-like 2 (NFE2L2/NRF2) in CSC-like properties of ALDH-high ovar...

journal_title：Cell death & disease

authors： Kim D,Choi BH,Ryoo IG,Kwak MK

更新日期：2018-08-30 00:00:00

abstract：:The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting M2-like TAMs toward the M1-like phenotype, which exerts tumor suppressor functions via phagocytosis and the secretion o...

journal_title：Cell death & disease

authors： Li M,Lai X,Zhao Y,Zhang Y,Li M,Li D,Kong J,Zhang Y,Jing P,Li H,Qin H,Shen L,Yao L,Li J,Dou K,Zhang J

更新日期：2018-02-14 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

journal_title：Cell death & disease

authors： Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

更新日期：2011-06-02 00:00:00

abstract：:The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins ...

journal_title：Cell death & disease

authors： Ke F,Lancaster GI,Grabow S,Murphy AJ,Strasser A

更新日期：2020-03-13 00:00:00

abstract：:Cellular senescence is an initial barrier to tumor development that prevents the proliferation of premalignant cells. However, some of the features of senescent cells seem to promote tumor progression via senescence-associated secretory phenotype (SASP). Here, we demonstrated that the protein level of forkhead box Q1 ...

journal_title：Cell death & disease

authors： Wang P,Lv C,Zhang T,Liu J,Yang J,Guan F,Hong T

更新日期：2017-07-20 00:00:00

abstract：:Cancer-initiating cell (CIC) is critical in cancer development, maintenance and recurrence. The reverse expression pattern of coxsackie and adenovirus receptor (CAR) and αν integrin in bladder cancer decreases the infection efficiency of adenovirus. We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carry...

journal_title：Cell death & disease

authors： Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L

更新日期：2015-05-14 00:00:00

abstract：:Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved overall survival in some cases. However, resistance to apoptosis often develops in cancer cells, and its occurrence is thought to contribute to treatment failure...

journal_title：Cell death & disease

authors： Wang L,Gundelach JH,Bram RJ

更新日期：2017-05-18 00:00:00

abstract：:Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has a fundamental role in cancer growth and metastasis. Even though PPP blockade has been pointed out as a very promising strategy against cancer, effective anti-PPP agents are not still available in the clinical setting. Here we demonstrate ...

journal_title：Cell death & disease

authors： Mele L,Paino F,Papaccio F,Regad T,Boocock D,Stiuso P,Lombardi A,Liccardo D,Aquino G,Barbieri A,Arra C,Coveney C,La Noce M,Papaccio G,Caraglia M,Tirino V,Desiderio V

更新日期：2018-05-01 00:00:00