Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy.

abstract：:Estrogen receptor-alpha positive (ER(+)) breast cancers comprise the majority of human breast cancers, but molecular mechanisms underlying this subtype of breast cancers remain poorly understood. Here, we show that ER(+) mammary luminal tumors arising in Tip30(-/-)MMTV-Neu mice exhibited increased enrichment of lumina...

journal_title：Cell death & disease

authors： Chen F,Li A,Gao S,Hollern D,Williams M,Liu F,VanSickle EA,Andrechek E,Zhang C,Yang C,Luo R,Xiao H

更新日期：2014-05-22 00:00:00

abstract：:MicroRNAs (miRNAs) have been demonstrated to affect the biological processes of cancers and showed great potential for prognostic biomarkers. In this study, we screened differentially expressed miRNAs in ccRCC based on three dimensions of metastasis, prognosis, and differential expression compared to normal tissue usi...

journal_title：Cell death & disease

authors： Li Z,Zhao S,Zhu S,Fan Y

更新日期：2021-01-04 00:00:00

abstract：:The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). The purpose of the present study was to explore the clinical significance and underlying mechanisms of a significantly dysregulated lncRNA (NEAT1) in HGSOC. Our...

journal_title：Cell death & disease

authors： Yong W,Yu D,Jun Z,Yachen D,Weiwei W,Midie X,Xingzhu J,Xiaohua W

更新日期：2018-08-28 00:00:00

abstract：:The multi-BCL-2 homology domain pro-apoptotic BCL-2 family members BAK and BAX have critical roles in apoptosis. They are essential for mitochondrial outer-membrane permeabilization, leading to the release of apoptogenic factors such as cytochrome-c, which promote activation of the caspase cascade and cellular demolit...

journal_title：Cell death & disease

authors： Ke F,Bouillet P,Kaufmann T,Strasser A,Kerr J,Voss AK

更新日期：2013-06-06 00:00:00

abstract：:Mitochondrial biogenesis and mitophagy are recognized as critical processes underlying mitochondrial homeostasis. However, the molecular pathway(s) coordinating the balance between these cellular programs is still poorly investigated. Here, we show an induction of the nuclear and mitochondrial peroxisome proliferator-...

journal_title：Cell death & disease

authors： Baldelli S,Aquilano K,Ciriolo MR

更新日期：2014-11-06 00:00:00

abstract：:Plastic phenotype convention between glioma stem cells (GSCs) and non-stem tumor cells (NSTCs) significantly fuels glioblastoma heterogeneity that causes therapeutic failure. Recent progressions indicate that glucose metabolic reprogramming could drive cell fates. However, the metabolic pattern of GSCs and NSTCs and i...

journal_title：Cell death & disease

authors： Zhou K,Yao YL,He ZC,Chen C,Zhang XN,Yang KD,Liu YQ,Liu Q,Fu WJ,Chen YP,Niu Q,Ma QH,Zhou R,Yao XH,Zhang X,Cui YH,Bian XW,Shi Y,Ping YF

更新日期：2018-09-24 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are unique male germline stem cells that support spermatogenesis and male fertility. Long non-coding RNAs (lncRNA) have been identified as key regulators of stem cell fate; however, their role in SSCs has not been explored. Here, we report that a novel spermatogonia-specific lncRNA (ln...

journal_title：Cell death & disease

authors： Li L,Wang M,Wang M,Wu X,Geng L,Xue Y,Wei X,Jia Y,Wu X

更新日期：2016-03-10 00:00:00

abstract：:Drug resistance is one of the major hurdles for cancer treatment. However, the underlying mechanisms are still largely unknown and therapeutic options remain limited. In this study, we show that microRNA (miR)-587 confers resistance to 5-fluorouracil (5-FU)-induced apoptosis in vitro and reduces the potency of 5-FU in...

journal_title：Cell death & disease

authors： Zhang Y,Talmon G,Wang J

更新日期：2015-08-06 00:00:00

abstract：:Hepatocyte transplantation as a substitute strategy of orthotopic liver transplantation is being studied for treating end-stage liver diseases. Several technical hurdles must be overcome in order to achieve the therapeutic liver repopulation, such as the problem of insufficient expansion of the transplanted hepatocyte...

journal_title：Cell death & disease

authors： Xiang D,Liu CC,Wang MJ,Li JX,Chen F,Yao H,Yu B,Lu L,Borjigin U,Chen YX,Zhong L,Wangensteen KJ,He ZY,Wang X,Hu YP

更新日期：2014-05-22 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has strong neuroprotective and neurorestorative effects on dopaminergic (DA) neurons in the substantia nigra (SN); however, the underlying molecular mechanisms remain to be fully elucidated. In this study, we found that the expression level of transcription factor Six...

journal_title：Cell death & disease

authors： Gao J,Kang XY,Sun S,Li L,Zhang BL,Li YQ,Gao DS

更新日期：2016-05-05 00:00:00

abstract：:ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple ...

journal_title：Cell death & disease

authors： Li L,Su N,Zhou T,Zheng D,Wang Z,Chen H,Yuan S,Li W

更新日期：2018-02-02 00:00:00

abstract：:MiR34 involvement in myocardial injury repair and ageing has been well documented in mouse model. Our aim was to establish whether the inhibition of miR34 expression through locked nucleic acid (LNA) could be used as a pharmacological intervention to enhance human heart repair. Cardiac progenitor cells were obtained b...

journal_title：Cell death & disease

authors： Iannolo G,Sciuto MR,Raffa GM,Pilato M,Conaldi PG

更新日期：2018-03-06 00:00:00

abstract：:Lung adenocarcinoma remains a threat to human health due to its high rate of recurrence and distant metastasis. However, the molecular mechanism underlying lung adenocarcinoma metastasis remains yet incompletely understood. Here, we show that upregulated expression of polypeptide N-acetylgalactosaminyltransferase6 (GA...

journal_title：Cell death & disease

authors： Song J,Liu W,Wang J,Hao J,Wang Y,You X,Du X,Zhou Y,Ben J,Zhang X,Ye M,Wang Q

更新日期：2020-05-11 00:00:00

abstract：:Little is known about the function of Keratin 80 (KRT80), an epithelial keratin, in cancer. This study investigated the role of KRT80 in the prognosis of colorectal carcinoma (CRC) and the underlying mechanisms involved in CRC migration and invasion. We analyzed the expression of KRT80 using The Cancer Genome Atlas an...

journal_title：Cell death & disease

authors： Li C,Liu X,Liu Y,Liu X,Wang R,Liao J,Wu S,Fan J,Peng Z,Li B,Wang Z

更新日期：2018-09-27 00:00:00

abstract：:Melanoma is a kind of tumor that originates from melanocytes and is characterized by chemoresistance and distant metastasis. Although the complete pathogenesis of melanoma remains unclear, increasing evidence suggests that circular RNAs (circRNAs) may be involved. In the present study, we identified a circular RNA, ci...

journal_title：Cell death & disease

authors： Qian P,Linbo L,Xiaomei Z,Hui P

更新日期：2020-04-23 00:00:00

abstract：:Mucin is an important physical barrier against enteric pathogens. VvpE is an elastase encoded by Gram-negative bacterium Vibrio vulnificus; however, the functional role of VvpE in intestinal mucin (Muc) production is yet to be elucidated. The recombinant protein (r) VvpE significantly reduced the level of Muc2 in huma...

journal_title：Cell death & disease

authors： Lee SJ,Jung YH,Oh SY,Jang KK,Lee HS,Choi SH,Han HJ

更新日期：2015-06-18 00:00:00

abstract：:Gastric cancer (GC) is one of the most leading malignancies. Long noncoding RNA is related to GC. In this study, 11 miRNAs in the exosomes and six lncRNAs in the tissues was examined by qRT-PCR. Correlation analysis was used to analyze the relationship between miRNAs in exosome and lncRNAs in the tissues. Four miRNAs ...

journal_title：Cell death & disease

authors： Zhang J,Qiu WQ,Zhu H,Liu H,Sun JH,Chen Y,Shen H,Qian CL,Shen ZY

更新日期：2020-09-19 00:00:00

abstract：:The nuclear localization signal (NLS) in kinesin-14 KIFC1 is associated with nuclear importins and Ran gradient, but detailed mechanism remains unknown. In this study, we found that KIFC1 proteins have specific transport characteristics during cell cycle. In the absence of KIFC1, cell cycle kinetics decrease significa...

journal_title：Cell death & disease

authors： Wei YL,Yang WX

更新日期：2019-05-24 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...

journal_title：Cell death & disease

authors： Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

更新日期：2017-01-05 00:00:00

abstract：:Noncoding RNAs plays an important role in hepatocellular carcinoma (HCC). Here, we show that miR-124 was downregulated in HCC tissues and that the ectopic expression of miR-124 inhibited the proliferation and migration of HCC cells. We proposed that aquaporin 3 (AQP3) is a direct target of miR-124. AQP3 was upregulate...

journal_title：Cell death & disease

authors： Chen G,Shi Y,Liu M,Sun J

更新日期：2018-02-07 00:00:00

abstract：:Alzheimer's disease (AD) is pathologically characterised by the age-dependent deposition of β-amyloid (Aβ) in senile plaques, intraneuronal accumulation of tau as neurofibrillary tangles, synaptic dysfunction and neuronal death. Neuroinflammation, typified by the accumulation of activated microglia and reactive astroc...

journal_title：Cell death & disease

authors： Garwood CJ,Pooler AM,Atherton J,Hanger DP,Noble W

更新日期：2011-06-02 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a highly aggressive tumor characterized by distant metastasis. Deletion or down-regulation of the tumor suppressor protein ras-association domain family protein1 isoform A (RASSF1A) has been confirmed to be a key event in NPC progression; however, little is known about the effects or ...

journal_title：Cell death & disease

authors： Liang YY,Deng XB,Lin XT,Jiang LL,Huang XT,Mo ZW,Yuan YW,Teh MT

更新日期：2020-10-14 00:00:00

abstract：:Radiotherapy for head and neck cancer is associated with impairment of salivary gland function and consequent xerostomia, which has a devastating effect on the quality of life of the patients. The mechanism of radiation-induced salivary gland damage is not completely understood. Cellular senescence is a permanent stat...

journal_title：Cell death & disease

authors： Peng X,Wu Y,Brouwer U,van Vliet T,Wang B,Demaria M,Barazzuol L,Coppes RP

更新日期：2020-10-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Luo X,Wang D,Zhu X,Wang G,You Y,Ning Z,Li Y,Jin S,Huang Y,Hu Y,Chen T,Meng Y,Li X

更新日期：2019-06-17 00:00:00

abstract：:NRLP3 inflammasome is a protein complex involved in the maturation of IL1β. In the onset of type 1 diabetes as well as in islet transplantation, IL-1β is one of the cytokines involved in the recruitment of immune cells in islets and eventually in islet destruction. Whether IL-1β is produced by islet cells is still und...

journal_title：Cell death & disease

authors： Lebreton F,Berishvili E,Parnaud G,Rouget C,Bosco D,Berney T,Lavallard V

更新日期：2018-06-25 00:00:00

abstract：:Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective a...

journal_title：Cell death & disease

authors： Fichtner M,Bozkurt E,Salvucci M,McCann C,McAllister KA,Halang L,Düssmann H,Kinsella S,Crawford N,Sessler T,Longley DB,Prehn JHM

更新日期：2020-11-30 00:00:00

abstract：:The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have indicated that SLC15A3 transcripts are mainly expressed in the lymphatic system, however, its regulation and biological role in innate im...

journal_title：Cell death & disease

authors： Song F,Yi Y,Li C,Hu Y,Wang J,Smith DE,Jiang H

更新日期：2018-07-10 00:00:00

abstract：:The wogonin-containing herb Scutellaria baicalensis has successfully been used for curing various diseases in traditional Chinese medicine. Wogonin has been shown to induce apoptosis in different cancer cells and to suppress growth of human cancer xenografts in vivo. However, its direct targets remain unknown. In this...

journal_title：Cell death & disease

authors： Polier G,Ding J,Konkimalla BV,Eick D,Ribeiro N,Köhler R,Giaisi M,Efferth T,Desaubry L,Krammer PH,Li-Weber M

更新日期：2011-07-21 00:00:00

abstract：:Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, un...

journal_title：Cell death & disease

authors： Ali A,Zhang P,Liangfang Y,Wenshe S,Wang H,Lin X,Dai Y,Feng XH,Moses R,Wang D,Li X,Xiao J

更新日期：2015-03-12 00:00:00

abstract：:The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes...

journal_title：Cell death & disease

authors： Yang J,Kim KS,Iyirhiaro GO,Marcogliese PC,Callaghan SM,Qu D,Kim WJ,Slack RS,Park DS

更新日期：2019-02-12 00:00:00