Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation.

abstract：:The ubiquitin-proteasome system (UPS) and macroautophagy (autophagy) are central to normal proteostasis and interdependent in that autophagy is known to compensate for the UPS to alleviate ensuing proteotoxic stress that impairs cell function. UPS and autophagy dysfunctions are believed to have a major role in the pat...

journal_title：Cell death & disease

authors： Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L

更新日期：2017-01-05 00:00:00

abstract：:Glioblastoma (GBM) is the most common and aggressive brain tumor and is associated with poor prognosis. GBM cells are frequently resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and finding new combinatorial therapies to sensitize glioma cells to TRAIL remains an important challenge. PIM ki...

journal_title：Cell death & disease

authors： Serrano-Saenz S,Palacios C,Delgado-Bellido D,López-Jiménez L,Garcia-Diaz A,Soto-Serrano Y,Casal JI,Bartolomé RA,Fernández-Luna JL,López-Rivas A,Oliver FJ

更新日期：2019-01-18 00:00:00

abstract：:This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl4) in a murine model and the underlying molecular mechanisms. Ninety-six mice were randomly divided into the control (n = 8), CQ (n = 8), CCl4 (n = 40), and CCl4 + CQ (n = 40) treatment gro...

journal_title：Cell death & disease

authors： Dai C,Xiao X,Li D,Tun S,Wang Y,Velkov T,Tang S

更新日期：2018-11-26 00:00:00

abstract：:The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...

journal_title：Cell death & disease

authors： Li M,Han Y,Zhou H,Li X,Lin C,Zhang E,Chi X,Hu J,Xu H

更新日期：2018-01-24 00:00:00

abstract：:Reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress are paradoxically implicated in myocardial ischemia/reperfusion (I/R) injury and cardioprotection. However, the precise interpretation for the dual roles of ROS and its relationship with the ER stress during I/R remain elusive. Here we investigated th...

journal_title：Cell death & disease

authors： Wang ZH,Liu JL,Wu L,Yu Z,Yang HT

更新日期：2014-06-19 00:00:00

abstract：:Induction of lethal autophagy has become a strategy to eliminate glioma cells, but it remains elusive whether autophagy contributes to cell death via causing mitochondria damage and nuclear translocation of apoptosis inducing factor (AIF). In this study, we find that silibinin induces AIF translocation from mitochondr...

journal_title：Cell death & disease

authors： Wang C,He C,Lu S,Wang X,Wang L,Liang S,Wang X,Piao M,Cui J,Chi G,Ge P

更新日期：2020-08-14 00:00:00

abstract：:The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...

journal_title：Cell death & disease

authors： Kuo CJ,Wang ST,Lin CM,Chiu HC,Huang CR,Lee DY,Chang GD,Chou TC,Chen JW,Chen CS

更新日期：2018-03-07 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27. EZH2 is overexpressed in metastatic prostate cancer and has been shown to promote cell proliferation and metastasis. Here we show that EZH2 ...

journal_title：Cell death & disease

authors： Zhang Q,Padi SK,Tindall DJ,Guo B

更新日期：2014-10-23 00:00:00

abstract：:While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizing agents. Here we report that TRAIL-induced apoptosis in PDA cell li...

journal_title：Cell death & disease

authors： Zhang JS,Herreros-Villanueva M,Koenig A,Deng Z,de Narvajas AA,Gomez TS,Meng X,Bujanda L,Ellenrieder V,Li XK,Kaufmann SH,Billadeau DD

更新日期：2014-03-27 00:00:00

abstract：:The aim of the present report was to investigate whether, in the mammalian spinal cord, cell death induced by transient excitotoxic stress could trigger activation and proliferation of endogenous neuroprogenitor cells as a potential source of a lesion repair process and the underlying time course. Because it is diffic...

journal_title：Cell death & disease

authors： Mazzone GL,Mladinic M,Nistri A

更新日期：2013-10-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Cell death & disease

authors： Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X

更新日期：2019-09-05 00:00:00

abstract：:Despite the introduction of novel targeted therapies, chemotherapy still remains the primary treatment for metastatic melanoma in poorly funded healthcare environments or in case of disease relapse, with no reliable molecular markers for progression-free survival (PFS) available. As chemotherapy primarily eliminates c...

journal_title：Cell death & disease

authors： Guttà C,Rahman A,Aura C,Dynoodt P,Charles EM,Hirschenhahn E,Joseph J,Wouters J,de Chaumont C,Rafferty M,Warren M,van den Oord JJ,Gallagher WM,Rehm M

更新日期：2020-02-13 00:00:00

abstract：:Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effect...

journal_title：Cell death & disease

authors： Pollutri D,Patrizi C,Marinelli S,Giovannini C,Trombetta E,Giannone FA,Baldassarre M,Quarta S,Vandewynckel YP,Vandierendonck A,Van Vlierberghe H,Porretti L,Negrini M,Bolondi L,Gramantieri L,Fornari F

更新日期：2018-01-05 00:00:00

abstract：:Cornelia de Lange Syndrome is a severe genetic disorder characterized by malformations affecting multiple systems, with a common feature of severe mental retardation. Genetic variants within four genes (NIPBL (Nipped-B-like), SMC1A, SMC3, and HDAC8) are believed to be responsible for the majority of cases; all these g...

journal_title：Cell death & disease

authors： Pistocchi A,Fazio G,Cereda A,Ferrari L,Bettini LR,Messina G,Cotelli F,Biondi A,Selicorni A,Massa V

更新日期：2013-10-17 00:00:00

abstract：:Epigenetic alteration of tumor suppression gene is one of the most significant indicators in human esophageal squamous cell carcinoma (ESCC). In this study, we identified a novel ESCC hypermethylation biomarker ZNF132 by integrative computational analysis to comprehensive genome-wide DNA methylation microarray dataset...

journal_title：Cell death & disease

authors： Jiang D,He Z,Wang C,Zhou Y,Li F,Pu W,Zhang X,Feng X,Zhang M,Yecheng X,Xu Y,Jin L,Guo S,Wang J,Wang M

更新日期：2018-12-18 00:00:00

abstract：:The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...

journal_title：Cell death & disease

authors： Yun JH,Park SW,Kim JH,Park YJ,Cho CH,Kim JH

更新日期：2016-02-18 00:00:00

abstract：:Recent studies have documented the diverse role of host immunity in infection by the protozoan parasite, Toxoplasma gondii. However, the contribution of the β-catenin pathway in this process has not been explored. Here, we show that AKT-mediated phosphorylated β-catenin supports T. gondii multiplication which is arres...

journal_title：Cell death & disease

authors： Majumdar T,Sharma S,Kumar M,Hussain MA,Chauhan N,Kalia I,Sahu AK,Rana VS,Bharti R,Haldar AK,Singh AP,Mazumder S

更新日期：2019-02-15 00:00:00

abstract：:Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy a...

journal_title：Cell death & disease

authors： Liu B,Wen X,Cheng Y

更新日期：2013-10-31 00:00:00

abstract：:Back pain is a leading cause of global disability and is strongly associated with intervertebral disc (IVD) degeneration (IDD). Hallmarks of IDD include progressive cell loss and matrix degradation. The Akt signaling pathway regulates cellularity and matrix production in IVDs and its inactivation is known to contribut...

journal_title：Cell death & disease

authors： Zhang C,Smith MP,Zhou GK,Lai A,Hoy RC,Mroz V,Torre OM,Laudier DM,Bradley EW,Westendorf JJ,Iatridis JC,Illien-Jünger S

更新日期：2019-10-03 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) can be divided into groups based on biomarkers of poor prognosis. The expression of the tyrosine kinase ZAP-70 (member of the Syk tyrosine kinase family) in CLL cells is associated with shorter overall survival in CLL patients. Currently, there is a lack of targeted therapies for pat...

journal_title：Cell death & disease

authors： Dielschneider RF,Xiao W,Yoon JY,Noh E,Banerji V,Li H,Marshall AJ,Johnston JB,Gibson SB

更新日期：2014-10-02 00:00:00

abstract：:Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improv...

journal_title：Cell death & disease

authors： Yadav SK,Kambis TN,Kar S,Park SY,Mishra PK

更新日期：2020-03-13 00:00:00

abstract：:Psoriasis is an autoimmune skin disease, where chronic immune responses due to exaggerated cytokine signaling, abnormal differentiation, and evasion of keratinocytes apoptosis plays a crucial role in mediating abnormal keratinocytes hyperproliferation. From the therapeutic perspective, the molecules with strong anti-p...

journal_title：Cell death & disease

authors： Thatikonda S,Pooladanda V,Sigalapalli DK,Godugu C

更新日期：2020-01-10 00:00:00

abstract：:Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all DIPG are characterized by a lysine-to-methionine substitution in histone 3, which leads to global H3K27 hypomethylation accompanied by H3K27 hyperacetylation. Hyperacetylati...

journal_title：Cell death & disease

authors： Wiese M,Hamdan FH,Kubiak K,Diederichs C,Gielen GH,Nussbaumer G,Carcaboso AM,Hulleman E,Johnsen SA,Kramm CM

更新日期：2020-08-21 00:00:00

abstract：:Recent cases of successful control of human immunodeficiency virus (HIV) by bone marrow transplant in combination with suppressive antiretroviral therapy (ART) and very early initiation of ART have provided proof of concept that HIV infection might now be cured. Current efforts focusing on gene therapy, boosting HIV-s...

journal_title：Cell death & disease

authors： Badley AD,Sainski A,Wightman F,Lewin SR

更新日期：2013-07-11 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been reported to localize in colorectal carcinomas, and participate in the formation of the tumor microenvironment. They have recently been isolated from colorectal cancer tissues, and are implicated in the growth, invasion, and metastasis of cancer cells. However, the roles and deta...

journal_title：Cell death & disease

authors： Zhang X,Hu F,Li G,Li G,Yang X,Liu L,Zhang R,Zhang B,Feng Y

更新日期：2018-01-18 00:00:00

abstract：:Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhib...

journal_title：Cell death & disease

authors： Chen L,Guo P,He Y,Chen Z,Chen L,Luo Y,Qi L,Liu Y,Wu Q,Cui Y,Fang F,Zhang X,Song T,Guo H

更新日期：2018-05-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but its role in idiopathic pulmonary fibrosis (IPF) is not fully understood. In this study, we found lncRNA Hoxaas3 (Hoxaas3) was up-regulated in the mice model of BLM-induced PF and TGF-β1-induced fibrogenesis in lung fibrobla...

journal_title：Cell death & disease

authors： Lin S,Zhang R,Xu L,Ma R,Xu L,Zhu L,Hu J,An X

更新日期：2020-08-26 00:00:00

abstract：:Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method for ALI. However, the potential mechanism by which MSC regulates the progression of ALI remains blurry. The present study focused on investigati...

journal_title：Cell death & disease

authors： Xiao K,He W,Guan W,Hou F,Yan P,Xu J,Zhou T,Liu Y,Xie L

更新日期：2020-10-15 00:00:00

abstract：:The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target. Although this proposition is supported by the clinical success of proteasome inhibitors in some malignancies, most cancers are resistant to proteasome inhibition. The ...

journal_title：Cell death & disease

authors： Parzych K,Chinn TM,Chen Z,Loaiza S,Porsch F,Valbuena GN,Kleijnen MF,Karadimitris A,Gentleman E,Keun HC,Auner HW

更新日期：2015-12-31 00:00:00

abstract：:DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoan Leishmania. We show that genetic inactivation of DDX3 leads ...

journal_title：Cell death & disease

authors： Padmanabhan PK,Zghidi-Abouzid O,Samant M,Dumas C,Aguiar BG,Estaquier J,Papadopoulou B

更新日期：2016-10-13 00:00:00