Abstract:
:Spermatogonial stem cells (SSCs) are unique male germline stem cells that support spermatogenesis and male fertility. Long non-coding RNAs (lncRNA) have been identified as key regulators of stem cell fate; however, their role in SSCs has not been explored. Here, we report that a novel spermatogonia-specific lncRNA (lncRNA033862) is essential for the survival of murine SSCs. LncRNA033862 is expressed in early spermatogonia including SSC and was among 805 lncRNAs identified by global expression profiling as responsive to glial cell-derived neurotrophic factor (GDNF), a growth factor required for SSC self-renewal and survival. LncRNA033862 is an antisense transcript of the GDNF receptor alpha1 (Gfra1) that lacks protein coding potential and regulates Gfra1 expression levels by interacting with Gfra1 chromatin. Importantly, lncRNA033862 knockdown severely impairs SSC survival and their capacity to repopulate recipient testes in a transplantation assay. Collectively, our data provide the first evidence that long non-coding RNAs (lncRNAs) regulate SSC fate.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Li L,Wang M,Wang M,Wu X,Geng L,Xue Y,Wei X,Jia Y,Wu Xdoi
10.1038/cddis.2016.24subject
Has Abstractpub_date
2016-03-10 00:00:00pages
e2140issn
2041-4889pii
cddis201624journal_volume
7pub_type
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pub_type: 已发布勘误
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