Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis.

abstract：:The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila melanogaster upon exposure to the superoxide generator and neurotoxic ...

journal_title：Cell death & disease

authors： Minois N,Carmona-Gutierrez D,Bauer MA,Rockenfeller P,Eisenberg T,Brandhorst S,Sigrist SJ,Kroemer G,Madeo F

更新日期：2012-10-11 00:00:00

abstract：:Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in the biological behaviors of glioblastoma. Here, we elucidated the function and possible molecular mechanisms of the effect of some ncRNAs and NR2C2-uORF on the biological behaviors of glioma...

journal_title：Cell death & disease

authors： Fan Z,Zheng J,Xue Y,Liu X,Wang D,Yang C,Ma J,Liu L,Ruan X,Wang Z,Liu Y

更新日期：2018-12-05 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common brain tumour, characterized by a central and partially necrotic (i.e., hypoxic) core enriched in cancer stem cells (CSCs). We previously showed that the most hypoxic and immature (i.e., CSCs) GBM cells were resistant to Temozolomide (TMZ) in vitro, owing to a particular...

journal_title：Cell death & disease

authors： Persano L,Pistollato F,Rampazzo E,Della Puppa A,Abbadi S,Frasson C,Volpin F,Indraccolo S,Scienza R,Basso G

更新日期：2012-10-18 00:00:00

abstract：:HIV-1 Nef protein has key roles at almost all stages of the viral life cycle. We assessed the role of the Nef/eEF1A (eukaryotic translation elongation factor 1-alpha) complex in nucleocytoplasmic shuttling in primary human macrophages. Nuclear retention experiments and inhibition of the exportin-t (Exp-t) pathway sugg...

journal_title：Cell death & disease

authors： Abbas W,Khan KA,Tripathy MK,Dichamp I,Keita M,Rohr O,Herbein G

更新日期：2012-04-05 00:00:00

abstract：:Autophagy is a pivotal intracellular process by which cellular macromolecules are degraded upon various stimuli. A failure in the degradation of autophagic substrates such as impaired organelles and protein aggregates leads to their accumulations, which are characteristics of many neurodegenerative diseases. Pharmacol...

journal_title：Cell death & disease

authors： Yoon YS,Cho ED,Jung Ahn W,Won Lee K,Lee SJ,Lee HJ

更新日期：2017-10-05 00:00:00

abstract：:Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments as these cells play critical roles in tumor progression and frequently antagonize the response to treatments. TAMs are usually associated to an M2-like phenotype, characterized by anti-inflammatory and protumoral properties. This...

journal_title：Cell death & disease

authors： Genard G,Wera AC,Huart C,Le Calve B,Penninckx S,Fattaccioli A,Tabarrant T,Demazy C,Ninane N,Heuskin AC,Lucas S,Michiels C

更新日期：2018-06-27 00:00:00

abstract：:Mitochondrial ferritin (FtMt) is a mitochondrially localized protein possessing ferroxidase activity and the ability to store iron. FtMt overexpression in cultured cells protects against oxidative damage by sequestering redox-active, intracellular iron. Here, we found that acute exhaustive exercise significantly incre...

journal_title：Cell death & disease

authors： Wu W,Chang S,Wu Q,Xu Z,Wang P,Li Y,Yu P,Gao G,Shi Z,Duan X,Chang YZ

更新日期：2016-11-17 00:00:00

abstract：:The mitochondrial permeability transition pore (mPTP) plays a critical role in the pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although the pore structure is still unresolved, the mechanism through which cyclophilin D (CypD) regulates mPTP opening is the subject of intensive studies...

journal_title：Cell death & disease

authors： Hurst S,Gonnot F,Dia M,Crola Da Silva C,Gomez L,Sheu SS

更新日期：2020-08-19 00:00:00

abstract：:Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While studies have been conducted in these research areas, the pathogenesis and mechanisms of MetS remain debatable. Lines of evidence show that ph...

journal_title：Cell death & disease

authors： Menikdiwela KR,Ramalingam L,Rasha F,Wang S,Dufour JM,Kalupahana NS,Sunahara KKS,Martins JO,Moustaid-Moussa N

更新日期：2020-02-03 00:00:00

abstract：:Global cerebral ischemia/reperfusion (I/R) facilitates the activation of procaspase-3 and promotes apoptosis in hippocampus. But the mechanisms have remained uncharacterized. Protein S-nitrosylation and denitrosylation is an important reversible posttranslational modification, which is a common mechanism in signal tra...

journal_title：Cell death & disease

authors： Sun N,Hao JR,Li XY,Yin XH,Zong YY,Zhang GY,Gao C

更新日期：2013-08-15 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating agent currently used as first-line therapy for gliomas treatment due to its DNA-damaging effect. However, drug resistance occurs, preventing multi-cycle use of this chemotherapeutic agent. One of the major mechanisms of cancer drug resistance is enhanced activity of a DNA repair enz...

journal_title：Cell death & disease

authors： Fan CH,Liu WL,Cao H,Wen C,Chen L,Jiang G

更新日期：2013-10-24 00:00:00

abstract：:As an important modality for the local control of colorectal cancer (CRC), radiotherapy or neoadjuvant radiotherapy is widely applied in the clinic, but radioresistance has become a major obstacle for CRC radiotherapy. Here we reported that B7-H3, an important costimulatory molecule, is associated with radioresistance...

journal_title：Cell death & disease

authors： Ma Y,Zhan S,Lu H,Wang R,Xu Y,Zhang G,Cao L,Shi T,Zhang X,Chen W

更新日期：2020-10-03 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation and has an important role in metabolic syndrome. Phosphorylation of the receptor's ligand-binding domain at serine 273 has been shown to change the expression of a large number of genes implicated in obesity. The d...

journal_title：Cell death & disease

authors： Jurkowski W,Roomp K,Crespo I,Schneider JG,Del Sol A

更新日期：2011-08-11 00:00:00

abstract：:Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette smoke, the detailed pathophysiological mechanisms are not fully understood. Based on controversial reports on the pro-atherogenic activity of cigarette smoke condens...

journal_title：Cell death & disease

authors： Messner B,Frotschnig S,Steinacher-Nigisch A,Winter B,Eichmair E,Gebetsberger J,Schwaiger S,Ploner C,Laufer G,Bernhard D

更新日期：2012-11-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, bu...

journal_title：Cell death & disease

authors： Geismann C,Grohmann F,Sebens S,Wirths G,Dreher A,Häsler R,Rosenstiel P,Hauser C,Egberts JH,Trauzold A,Schneider G,Sipos B,Zeissig S,Schreiber S,Schäfer H,Arlt A

更新日期：2014-10-09 00:00:00

abstract：:The mechanism by which tumor-associated macrophages (TAMs) affect cancer progression is not fully understood. This study developed a microfluidic-based co-culture device to mimic the tumor microenvironment to assess TAM effects on invasion and metastasis in NSCLC. The results showed lung carcinoma cells could cause ma...

journal_title：Cell death & disease

authors： Guo Z,Song J,Hao J,Zhao H,Du X,Li E,Kuang Y,Yang F,Wang W,Deng J,Wang Q

更新日期：2019-05-16 00:00:00

abstract：:β-Catenin has been widely implicated in the regulation of mammalian development and cellular homeostasis. However, the mechanisms by which Wnt/β-catenin signaling components regulate physiological events during brain development remain undetermined. Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin ...

journal_title：Cell death & disease

authors： Shin J,Shin Y,Oh SM,Yang H,Yu WJ,Lee JP,Huh SO,Lee SH,Suh YH,Chung S,Kim HS

更新日期：2014-10-16 00:00:00

abstract：:Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as TNF Receptor Superfamily members. Loss of XIAP in humans causes X-linked Lymphoproliferative disease type 2 (XLP-2) and is often associated with Crohn's diseas...

journal_title：Cell death & disease

authors： Gradzka S,Thomas OS,Kretz O,Haimovici A,Vasilikos L,Wong WW,Häcker G,Gentle IE

更新日期：2018-05-01 00:00:00

abstract：: ...

journal_title：Cell death & disease

authors： Gatie MI,Assabgui AR,Kelly GM

更新日期：2018-10-22 00:00:00

abstract：:The unfolded protein response (UPR) triggered by endoplasmic reticulum (ER) stress is a feature of many neurodegenerative diseases including Alzheimer's disease, Huntington's disease and Parkinson's disease (PD). Although the vast majority of PD is sporadic, mutations in a number of genes including PARK7 which encodes...

journal_title：Cell death & disease

authors： Yang J,Kim KS,Iyirhiaro GO,Marcogliese PC,Callaghan SM,Qu D,Kim WJ,Slack RS,Park DS

更新日期：2019-02-12 00:00:00

abstract：:Senescence is a cellular response to damage and stress. The senescence response prevents cancer by suppressing the proliferation of cells with a compromised genome and contributes to optimal wound healing in normal tissues. Persistent senescent cells are also thought to drive aging and age-associated pathologies throu...

journal_title：Cell death & disease

authors： Laberge RM,Adler D,DeMaria M,Mechtouf N,Teachenor R,Cardin GB,Desprez PY,Campisi J,Rodier F

更新日期：2013-07-18 00:00:00

abstract：:Chronic psychological stress has been demonstrated to play an important role in several severe diseases, but whether it affects disease therapy or not remains unclear. Mesenchymal stem cells (MSCs) have been demonstrated to have therapeutic potentials in treating tissue injury based on their multidifferentiation poten...

journal_title：Cell death & disease

authors： Yang X,Han ZP,Zhang SS,Zhu PX,Hao C,Fan TT,Yang Y,Li L,Shi YF,Wei LX

更新日期：2014-06-26 00:00:00

abstract：:Increasing the sensitivity of glioblastoma cells to radiation is a promising approach to improve survival in patients with glioblastoma multiforme (GBM). This study aims to determine if serine/threonine phosphatase (protein phosphatase 6 (PP6)) is a molecular target for GBM radiosensitization treatment. The GBM orthot...

journal_title：Cell death & disease

authors： Shen Y,Wang Y,Sheng K,Fei X,Guo Q,Larner J,Kong X,Qiu Y,Mi J

更新日期：2011-12-08 00:00:00

abstract：:Gallbladder cancer (GBC) is a highly malignant bile duct cancer with poor prognosis due to early invasion and metastasis. However, the molecular mechanisms through which GBC cells interact with the tumor microenvironment (TME) remain poorly understood. Here, we examined the role of the tumor suppressor apoptosis-stimu...

journal_title：Cell death & disease

authors： Tian L,Deng Z,Xu L,Yang T,Yao W,Ji L,Lu Y,Zhang J,Liu Y,Wang J

更新日期：2018-11-02 00:00:00

abstract：:B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis. Bax is latent and monomeric in the cytosol but transforms into its lethal, mitochondria-embedded oligomeric form in response to cell stress, leading to the rele...

journal_title：Cell death & disease

authors： Xu XP,Zhai D,Kim E,Swift M,Reed JC,Volkmann N,Hanein D

更新日期：2013-06-20 00:00:00

abstract：:ZAK, a mixed lineage kinase, is often described as a positive or negative regulator of cell growth. We identified it as one of the top hits in our kinome cDNA screen for potent regulators of epithelial mesenchymal transition (EMT). Ectopic expression of ZAK promoted EMT phenotypes and apoptosis resistance in multiple ...

journal_title：Cell death & disease

authors： Li L,Su N,Zhou T,Zheng D,Wang Z,Chen H,Yuan S,Li W

更新日期：2018-02-02 00:00:00

abstract：:Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuronal loss that initiates in the substantia nigra pars compacta and by the formation of intracellular inclusions mainly constituted by aberrant α-synuclein (α-syn) deposits known as Lewy bodies. Most cases ...

journal_title：Cell death & disease

authors： Vicario M,Cieri D,Vallese F,Catoni C,Barazzuol L,Berto P,Grinzato A,Barbieri L,Brini M,Calì T

更新日期：2019-11-12 00:00:00

abstract：:Although it is becoming increasingly evident that maternal starvation during pregnancy can have permanent effects on a range of physiological processes in the offspring, scant information is available about the consequence of such condition for oogenesis and hence for lifetime reproductive success of progeny in mammal...

journal_title：Cell death & disease

authors： Wang JJ,Yu XW,Wu RY,Sun XF,Cheng SF,Ge W,Liu JC,Li YP,Liu J,Zou SH,De Felici M,Shen W

更新日期：2018-05-01 00:00:00

abstract：:Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell deat...

journal_title：Cell death & disease

authors： Kleih M,Böpple K,Dong M,Gaißler A,Heine S,Olayioye MA,Aulitzky WE,Essmann F

更新日期：2019-11-07 00:00:00

abstract：:Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an active component extracted from Andrographis paniculate, is prescribed as a treatment for upper respiratory tract infection. Here we rep...

journal_title：Cell death & disease

authors： Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y

更新日期：2019-12-20 00:00:00