Abstract:
:The subversion of the normal function exerted by the cellular prion protein (PrP(C)) in neurons by pathogenic prions is assumed to have a central role in the pathogenesis of transmissible spongiform encephalopathies. Using two murine models of prion infection, the 1C11 neuronal cell line and neurospheres, we document that prion infection is associated with the constitutive activation of signaling targets normally coupled with PrP(C), including the Fyn kinase, the mitogen-associated protein kinases ERK1/2 and the CREB transcription factor. PrP(C)-dependent signaling overactivation in infected cells is associated with the recruitment of p38 and JNK stress-associated kinases. Downstream from CREB, prion-infected cells exhibit reduced activity of the matrix metalloprotease (MMP)-9. As MMP-9 catalyzes the degradation of the amyloid A-beta peptide, the decrease in MMP-9 activity in prion-infected cells causes a significant impairment of the clearance of A-beta, leading to its accumulation. By exploiting two 1C11-infected clones accumulating high or moderate levels of prions, we show that the prion-induced changes are correlated with the level of infectivity. Of note, a dose-dependent increase in A-beta levels was also found in the cerebrospinal fluid of mice inoculated with these infected clones. By demonstrating that pathogenic prions trigger increases in A-beta levels through the deviation of PrP(C) signaling, our data argue that A-beta may exacerbate prion-induced toxicity.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Pradines E,Hernandez-Rapp J,Villa-Diaz A,Dakowski C,Ardila-Osorio H,Haik S,Schneider B,Launay JM,Kellermann O,Torres JM,Mouillet-Richard Sdoi
10.1038/cddis.2012.195subject
Has Abstractpub_date
2013-01-10 00:00:00pages
e456issn
2041-4889pii
cddis2012195journal_volume
4pub_type
杂志文章abstract::We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increa...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.52
更新日期:2013-03-07 00:00:00
abstract::Adaptive responses of skeletal muscle regulate the nuclear shuttling of the sarcomeric protein Ankrd2 that can transduce different stimuli into specific adaptations by interacting with both structural and regulatory proteins. In a genome-wide expression study on Ankrd2-knockout or -overexpressing primary proliferating...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.525
更新日期:2014-01-16 00:00:00
abstract::The identification of specific drug targets guides the development of precise cancer treatments. Compared with oncogenes, tumor suppressor genes have been poorly studied in the treatment of breast cancer. We integrate the microRNA expression array from GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) d...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0128-y
更新日期:2018-01-24 00:00:00
abstract::Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in premature death at childhood and cells derived from CS patients display DNA repair and transcriptional defects. CS is caused by mutations in csa and csb genes, and patients with csb mutation are more prevalent. A hallmark...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.228
更新日期:2014-05-29 00:00:00
abstract::Myotonic dystrophy type 1 (DM1) is the most common type of adult muscular dystrophy caused by the expanded triple-nucleotides (CUG) repeats. Myoblast in DM1 displayed many defects, including defective myoblast differentiation, ribonuclear foci, and aberrant alternative splicing. Despite many were revealed to function ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-03112-6
更新日期:2020-10-22 00:00:00
abstract::Urethral hypoplasia, including failure of urethral tube closure, is one of the common phenotypes observed in hereditary human disorders, the mechanism of which remains unclear. The present study was thus designed to study the expression, functions, and related mechanisms of the LIM homeobox transcription factor Isl1 t...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1952-z
更新日期:2019-09-26 00:00:00
abstract::Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ enhances autophagy...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2644-4
更新日期:2020-06-08 00:00:00
abstract::Correction to: NPG Asia Materials (2018) https://doi.org/10.1038/s41427-018-0014-9 published online on 16 April 2018. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-018-0639-1
更新日期:2018-05-24 00:00:00
abstract::Breast cancer is the most common cancer type in women. Long non-coding RNAs (lncRNAs) have been reported as potential new diagnostic markers, prognostic factors, and therapeutic targets in cancer. However, the specific roles and mechanisms of lncRNAs in breast cancer remain to be elucidated. Here we demonstrated the d...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2557-2
更新日期:2020-05-07 00:00:00
abstract::Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realized through autocrin...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.445
更新日期:2013-11-07 00:00:00
abstract::One of the significant challenges for chemotherapy is the appearance of resistance to compounds. Although several signaling pathways have been implicated in the development of Adriamycin (ADM) resistance, mechanisms involved in ADM-resistant osteosarcoma progression remain unknown. The present study attempted to illus...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2573-2
更新日期:2020-05-13 00:00:00
abstract::Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.230
更新日期:2015-09-17 00:00:00
abstract::Hyperoxia treatment has been known to induce neuronal and glial death in the developing central nervous system. Retinopathy of prematurity (ROP) is a devastating disease in premature infants and a major cause of childhood vision impairment. Studies indicate that, in addition to vascular injury, retinal neurons are als...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.23
更新日期:2014-02-20 00:00:00
abstract::Mediators produced by the airway epithelium control the activation, recruitment, and survival of pulmonary dendritic cells (DC) that present antigen to CD4(+) T cells during the genesis and exacerbation of allergic asthma. The epithelial-derived acute phase protein, serum amyloid A (SAA), induces DC maturation and TH1...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.327
更新日期:2013-09-05 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-1722-y
更新日期:2019-06-17 00:00:00
abstract::Kidney aging leads to an increased incidence of end-stage renal disease (ESRD) in the elderly, and aging is a complex biological process controlled by signaling pathways and transcription factors. Podocyte senescence plays a central role in injury resulting from kidney aging. Here, we demonstrated the critical role of...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1933-2
更新日期:2019-09-17 00:00:00
abstract::This study aimed to evaluate treatment response, survival, safety profiles, and predictive factors to chimeric antigen receptor T cell (CAR-T) therapy in Chinese patients with relapsed or refractory B cell acute lymphoblast leukemia (R/R B-ALL). 39R/R B-ALL patients who underwent CAR-T therapy were included. Baseline ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2388-1
更新日期:2020-03-30 00:00:00
abstract::MicroRNAs (miRNAs) deregulation is frequent in human gastric cancers (GCs), but the role of specific miRNAs involved in this disease remains elusive. MiR-22 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.297
更新日期:2015-11-26 00:00:00
abstract::Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor-β1 (TGF-β1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dominant-negative mutant o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2010.21
更新日期:2010-05-20 00:00:00
abstract::Necroptosis is an inflammatory form of programmed cell death requiring receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL). The kinase of RIPK3 phosphorylates MLKL causing MLKL to form a pore-like structure, allowing intracellular contents to release and cell dea...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.20
更新日期:2017-02-02 00:00:00
abstract::Apoptosis is considered a crucial part of the host defense system in oysters according to previous reports; however, the exact process by which this occurs remains unclear. Besides, mitochondrial apoptosis is the primary method of apoptosis in vertebrate cells, but has been poorly studied in invertebrates and is quite...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.307
更新日期:2017-07-06 00:00:00
abstract::MicroRNAs have emerged as important post-transcriptional regulators of gene expression and are involved in diverse diseases and cellular process. Decreased expression of miR-181a has been observed in the patients with coronary artery disease, but its function and mechanism in atherogenesis is not clear. This study was...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1599-9
更新日期:2019-05-07 00:00:00
abstract::The WWOX tumor suppressor is a WW domain-containing protein. Its function in the cell has been shown to be mediated, in part, by interacting with its partners through its first WW (WW1) domain. Here, we demonstrated that WWOX via WW1 domain interacts with p53 homolog, ΔNp63α. This protein-protein interaction stabilize...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.6
更新日期:2013-01-31 00:00:00
abstract::Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional treatment associating surgical resection and subsequent radio-chemotherapy. Among these heterogeneous tumors, a subpopulation of chemo- and radioresistant GBM stem-like cells appears to be involved in the systematic GBM recurrence. Moreover...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.509
更新日期:2014-11-27 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a heterogeneous population of cells that proliferate in vitro as plastic-adherent cells, have a fibroblast-like morphology, form colonies in vitro and can differentiate into bone, cartilage and fat cells. The abundance, ease and repeatable access to subcutaneous adipose tissue and the...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.344
更新日期:2014-08-21 00:00:00
abstract::Natural-food-based compounds show substantial promise for prevention and biotherapy of cancers including leukemia. In general, their mechanism of action remains unclear, hampering rational use of these compounds. Herein we show that the common dietary flavonoid apigenin has anticancer activity, but also may decrease c...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2009.18
更新日期:2010-01-01 00:00:00
abstract::Mitochondrial dysfunction and synaptic damage are critical early features of Alzheimer's disease (AD) associated with amyloid β (Aβ) and τ. We previously reported that the scaffolding protein RanBP9, which is overall increased in AD, simultaneously promotes Aβ generation and focal adhesion disruption by accelerating t...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.203
更新日期:2013-01-24 00:00:00
abstract::Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1417-4
更新日期:2019-02-20 00:00:00
abstract::The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells. The serine/threonine kinase casein kinase 2 (CK2) has a well-reported role in prostate cancer resistance to apoptotic agents or anticancer drugs. However, the mechanistic understanding on how CK2 suppo...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.532
更新日期:2014-01-23 00:00:00
abstract::Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0337-z
更新日期:2018-02-15 00:00:00