Resistance to caspase-8 and -9 fragments in a malignant pleural mesothelioma cell line with acquired cisplatin-resistance.

abstract：:The role of T lymphocytes in central nervous system (CNS) injuries is controversial, with inconsistent results reported concerning the effects of T-lymphocyte transfer on spinal cord injury (SCI). Here, we demonstrate that a specific T-lymphocyte subset enhances functional recovery after contusion SCI in mice. Intrape...

journal_title：Cell death & disease

authors： Ishii H,Jin X,Ueno M,Tanabe S,Kubo T,Serada S,Naka T,Yamashita T

更新日期：2012-08-09 00:00:00

abstract：:Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis. Activation of the mechanistic target of rapamycin (mTOR) and hypoxia-inducible factor (HIF) transcription factors are crucial for the regulation of immune cell fu...

journal_title：Cell death & disease

authors： Zhu Q,Wang H,Jiang B,Ni X,Jiang L,Li C,Wang X,Zhang F,Ke B,Lu L

更新日期：2018-09-05 00:00:00

abstract：:Autophagy has emerged as a critical pathway in tumor development. S100A4 plays important roles in tumor metastasis, but its role in regulating autophagy has not been well characterized. In this study, we found that S100A4 was significantly upregulated in lung adenocarcinoma tissues. Clinical investigation demonstrated...

journal_title：Cell death & disease

authors： Hou S,Tian T,Qi D,Sun K,Yuan Q,Wang Z,Qin Z,Wu Z,Chen Z,Zhang J

更新日期：2018-02-15 00:00:00

abstract：:Glioma patients commonly suffer from epileptic seizures. However, the mechanisms of glioma-associated epilepsy are far to be completely understood. Using glioma-neurons co-cultures, we found that tumor cells are able to deeply influence neuronal chloride homeostasis, by depolarizing the reversal potential of γ-aminobu...

journal_title：Cell death & disease

authors： Di Angelantonio S,Murana E,Cocco S,Scala F,Bertollini C,Molinari MG,Lauro C,Bregestovski P,Limatola C,Ragozzino D

更新日期：2014-10-30 00:00:00

abstract：:Cellular acetylation homeostasis is a kinetic balance precisely controlled by histone acetyl-transferase (HAT) and histone deacetylase (HDAC) activities. The loss of the counterbalancing function of basal HAT activity alters the precious HAT:HDAC balance towards enhanced histone deacetylation, resulting in a loss of a...

journal_title：Cell death & disease

authors： Wu Y,Ma S,Xia Y,Lu Y,Xiao S,Cao Y,Zhuang S,Tan X,Fu Q,Xie L,Li Z,Yuan Z

更新日期：2017-01-26 00:00:00

abstract：:The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

journal_title：Cell death & disease

authors： Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

更新日期：2016-10-27 00:00:00

abstract：:miRNAs are involved in many physiologic and disease processes by virtue of degrading specific mRNAs or inhibiting their translation. miR-148a has been implicated in the control of tumor growth and cholesterol and triglyceride homeostasis using in vitro or in vivo gene expression- and silencing-based approaches. Here m...

journal_title：Cell death & disease

authors： Cheng L,Zhu Y,Han H,Zhang Q,Cui K,Shen H,Zhang J,Yan J,Prochownik E,Li Y

更新日期：2017-07-13 00:00:00

abstract：:Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic profile that is still not completely understood. In this study, using a whole gene microarray approach, we investigated age-dependent gene expression profile changes occurring in the hippocampus of young and old transgenic AD...

journal_title：Cell death & disease

authors： Gatta V,D'Aurora M,Granzotto A,Stuppia L,Sensi SL

更新日期：2014-02-13 00:00:00

abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

journal_title：Cell death & disease

authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

更新日期：2017-06-29 00:00:00

abstract：:Cancer stem cells (CSCs) represent a population of cancer cells that possess unique self-renewal and differentiation characteristics required for tumorigenesis and are resistant to chemotherapy-induced apoptosis. Lung CSCs can be enriched by several markers including drug-resistant side population (SP), CD133(pos) and...

journal_title：Cell death & disease

authors： Akunuru S,James Zhai Q,Zheng Y

更新日期：2012-07-19 00:00:00

abstract：:Maintaining mesothelial cell viability is critical to long-term successful peritoneal dialysis (PD) treatment. To clarify the viability mechanism of peritoneal mesothelial cells under PD solutions exposure, we examined the mechanisms of cellular response to this stress conditions. Here we report that the proteasome ac...

journal_title：Cell death & disease

authors： Wang HH,Lin CY,Su SH,Chuang CT,Chang YL,Lee TY,Lee SC,Chang CJ

更新日期：2016-07-21 00:00:00

abstract：:H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to induce chronic inflammation and apoptosis resistance. While H. pylori infection-induced expression of pro-inflammatory cytokines for chronic inflammation is well studied, th...

journal_title：Cell death & disease

authors： Chen Y,Sheppard D,Dong X,Hu X,Chen M,Chen R,Chakrabarti J,Zavros Y,Peek RM,Chen LF

更新日期：2020-08-21 00:00:00

abstract：:Senescence is an antiproliferative mechanism that can suppress tumor development and can be induced by oncogenes such as genes of the Ras family. Although studies have implicated bioactive sphingolipids (SL) in senescence, the specific mechanisms remain unclear. Here, using MCF10A mammary epithelial cells, we demonstr...

journal_title：Cell death & disease

authors： Trayssac M,Clarke CJ,Stith JL,Snider JM,Newen N,Gault CR,Hannun YA,Obeid LM

更新日期：2021-01-04 00:00:00

abstract：:Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes. However, their functions in cerebral ischemia remain largely unknown. Through an lncRNA array analysis in a rat model of focal cerebral ischemia/reperfusion (I/R), we have identified CAMK2D-associ...

journal_title：Cell death & disease

authors： Xu Q,Deng F,Xing Z,Wu Z,Cen B,Xu S,Zhao Z,Nepomuceno R,Bhuiyan MI,Sun D,Wang QJ,Ji A

更新日期：2016-03-31 00:00:00

abstract：:African swine fever virus (ASFV) infection induces apoptosis in the infected cell; however, the consequences of this activation on virus replication have not been defined. In order to identify the role of apoptosis in ASFV infection, we analyzed caspase induction during the infection and the impact of caspase inhibiti...

journal_title：Cell death & disease

authors： Galindo I,Hernáez B,Muñoz-Moreno R,Cuesta-Geijo MA,Dalmau-Mena I,Alonso C

更新日期：2012-07-05 00:00:00

abstract：:Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor micr...

journal_title：Cell death & disease

authors： Wang G,Wang Q,Liang N,Xue H,Yang T,Chen X,Qiu Z,Zeng C,Sun T,Yuan W,Liu C,Chen Z,He X

更新日期：2020-05-04 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcripti...

journal_title：Cell death & disease

authors： Tian YN,Chen HD,Tian CQ,Wang YQ,Miao ZH

更新日期：2020-01-28 00:00:00

abstract：:NRLP3 inflammasome is a protein complex involved in the maturation of IL1β. In the onset of type 1 diabetes as well as in islet transplantation, IL-1β is one of the cytokines involved in the recruitment of immune cells in islets and eventually in islet destruction. Whether IL-1β is produced by islet cells is still und...

journal_title：Cell death & disease

authors： Lebreton F,Berishvili E,Parnaud G,Rouget C,Bosco D,Berney T,Lavallard V

更新日期：2018-06-25 00:00:00

abstract：:Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs and PTK7 in cancers. In this study, we showed that PTK7 was significantly correlated with the Wnt/β-Catenin pathway and aggressive cli...

journal_title：Cell death & disease

authors： Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

更新日期：2018-10-22 00:00:00

abstract：:Many cancer therapies are being developed for the induction of durable anti-tumor immunity, especially for malignant tumors. The activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), can bridge innate and adaptive immune responses against tumors. However, APCs have an immunosu...

journal_title：Cell death & disease

authors： He K,Jia S,Lou Y,Liu P,Xu LX

更新日期：2019-03-04 00:00:00

abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease treatment, and organ transplantation. As the ethical issue of human ESCs and similarity of pig in human genome and physiological characteristics, the porcine iPSCs (piPSCs) have become an ideal ...

journal_title：Cell death & disease

authors： Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

更新日期：2019-02-20 00:00:00

abstract：:The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology over time, but the m...

journal_title：Cell death & disease

authors： Parker A,Vaux L,Patterson AM,Modasia A,Muraro D,Fletcher AG,Byrne HM,Maini PK,Watson AJM,Pin C

更新日期：2019-02-06 00:00:00

abstract：:The WWOX tumor suppressor is a WW domain-containing protein. Its function in the cell has been shown to be mediated, in part, by interacting with its partners through its first WW (WW1) domain. Here, we demonstrated that WWOX via WW1 domain interacts with p53 homolog, ΔNp63α. This protein-protein interaction stabilize...

journal_title：Cell death & disease

authors： Salah Z,Bar-mag T,Kohn Y,Pichiorri F,Palumbo T,Melino G,Aqeilan RI

更新日期：2013-01-31 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest and apoptosis in hum...

journal_title：Cell death & disease

authors： Liao YJ,Bai HY,Li ZH,Zou J,Chen JW,Zheng F,Zhang JX,Mai SJ,Zeng MS,Sun HD,Pu JX,Xie D

更新日期：2014-03-20 00:00:00

abstract：:We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-X(L) and MCL1 anti-apoptotic activity, using combined computational and experimental approaches. We found that miR-491-5p efficiently induces apoptosis in IGROV1-R10 cells by directly inhibiting BCL-X(L) expres...

journal_title：Cell death & disease

authors： Denoyelle C,Lambert B,Meryet-Figuière M,Vigneron N,Brotin E,Lecerf C,Abeilard E,Giffard F,Louis MH,Gauduchon P,Juin P,Poulain L

更新日期：2014-10-09 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) support tumorigenesis by stimulating cancer cell proliferation, and invasion, but how the premalignant stromal fibroblasts trigger epithelial changes remain unclear. We demonstrate that atypical ductal hyperplasia-associated fibroblasts (AHFs) are one kind of activated fibroblasts ...

journal_title：Cell death & disease

authors： Sun Y,Yang D,Xi L,Chen Y,Fu L,Sun K,Yin J,Li X,Liu S,Qin Y,Liu M,Hou Y

更新日期：2018-01-26 00:00:00

abstract：:Reactive gliosis is an early pathological feature common to most neurodegenerative diseases, yet its regulation and impact remain poorly understood. Normally astrocytes maintain a critical homeostatic balance. After stress or injury they undergo rapid parainflammatory activation, characterized by hypertrophy, and incr...

journal_title：Cell death & disease

authors： Livne-Bar I,Lam S,Chan D,Guo X,Askar I,Nahirnyj A,Flanagan JG,Sivak JM

更新日期：2016-09-29 00:00:00

abstract：:It is largely recognized that fibroblast activation protein (FAP) is expressed in cancer-associated fibroblasts (CAFs) of many human carcinomas. Furthermore, FAP was recently also reported to be expressed in carcinoma cells of the breast, stomach, pancreatic ductal adenocarcinoma, colorectum, and uterine cervix. The c...

journal_title：Cell death & disease

authors： Wang H,Wu Q,Liu Z,Luo X,Fan Y,Liu Y,Zhang Y,Hua S,Fu Q,Zhao M,Chen Y,Fang W,Lv X

更新日期：2014-04-10 00:00:00

abstract：:Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor...

journal_title：Cell death & disease

authors： Alaimo A,Lorenzoni M,Ambrosino P,Bertossi A,Bisio A,Macchia A,Zoni E,Genovesi S,Cambuli F,Foletto V,De Felice D,Soldovieri MV,Mosca I,Gandolfi F,Brunelli M,Petris G,Cereseto A,Villarroel A,Thalmann G,Carbone FG,Kr

更新日期：2020-12-07 00:00:00

abstract：:We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-free survival and overall survival. Cell sensitivity to SC66 was inversely correlated with phospho-Akt and COL1...

journal_title：Cell death & disease

authors： Wu YH,Huang YF,Chen CC,Chou CY

更新日期：2019-04-11 00:00:00