Abstract:
:Sepsis is a systemic inflammation caused by infection. The balance between M1-M2 macrophage polarization has an essential role in the pathogenesis of sepsis. However, the exact mechanism underlying macrophage polarization is unclear. We previously showed that levels of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) were significantly elevated in septic patients compared with those in nonseptic patients, and involved in the activation of Toll-like receptor (TLR) 2/c-Jun N-terminal kinase (JNK)/nuclear factor (NF)-κB pathway. In the present study, we explored whether MFHAS1 was involved in macrophage polarization and determined the effect of MFHAS1 on inflammation. We performed in vitro pulldown assays and in vivo co-immunoprecipitation assays and found that E3 ubiquitin ligase praja2 could directly bind to MFHAS1. In situ immunostaining analysis confirmed the colocalization of endogenous praja2 with MFHAS1. We first reported that praja2 promotes the accumulation of ubiquitylated MFHAS1 but does not degrade it. Moreover, our results indicate that MFHAS1 ubiquitylation by praja2 positively regulates TLR2-mediated JNK/p38 pathway and promotes M1 macrophage polarization, M2 to M1 macrophage transformation and inflammation.
journal_name
Cell Death Disjournal_title
Cell death & diseaseauthors
Zhong J,Wang H,Chen W,Sun Z,Chen J,Xu Y,Weng M,Shi Q,Ma D,Miao Cdoi
10.1038/cddis.2017.102subject
Has Abstractpub_date
2017-05-04 00:00:00pages
e2763issue
5issn
2041-4889pii
cddis2017102journal_volume
8pub_type
杂志文章abstract::High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated...
journal_title:Cell death & disease
pub_type: 杂志文章,收录出版
doi:10.1038/s41419-018-1169-6
更新日期:2019-01-15 00:00:00
abstract::In renal cell carcinoma, transglutaminase 2 (TGase 2) crosslinks p53 in autophagosomes, resulting in p53 depletion and the tumor's evasion of apoptosis. Inhibition of TGase 2 stabilizes p53 and induces tumor cells to enter apoptosis. This study explored the mechanism of TGase 2-dependent p53 degradation. We found that...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.14
更新日期:2016-03-31 00:00:00
abstract::In this study, the roles of p53 in impaired spermatogenic male germ cells of p53-deficient medaka were investigated by analyzing histological changes, and gene expressions of 42Sp50, Oct 4 and vitellogenin (VTG2) by RT-PCR or in situ hybridization in the testes. We found that a small number of oocyte-like cells (testi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2012.133
更新日期:2012-10-04 00:00:00
abstract::Redox imbalance generates multiple cellular damages leading to oxidative stress-mediated pathological conditions such as neurodegenerative diseases and cancer progression. Therefore, maintenance of reactive oxygen species (ROS) homeostasis is most important that involves well-defined antioxidant machinery. In the pres...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2014.355
更新日期:2014-08-28 00:00:00
abstract::Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid (FA) and cholesterol metabolism play important roles in ccRCC development. As a nuclear transcription factor receptor, Liver X receptor (LXR) regulates a variety of key molecules associated wi...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1654-6
更新日期:2019-05-28 00:00:00
abstract::Recombinant human bone morphogenetic protein-2 (rhBMP-2) is widely used in the clinic for bone defect reconstruction because of its powerful osteoinductive capacity. However, commercially available rhBMP-2 requires a high concentration in the clinical setting for consistent bone formation. A high dose of rhBMP-2 induc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0126-0
更新日期:2018-02-02 00:00:00
abstract::CCAAT/enhancer binding protein beta (C/EBPβ), a transcription factor expressed in muscle satellite cells (SCs), inhibits the myogenic program and is downregulated early in differentiation. In a conditional null model in which C/EBPβ expression is knocked down in paired box protein 7+ (Pax7+) SCs, cardiotoxin (CTX) inj...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.4
更新日期:2016-02-25 00:00:00
abstract::The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas Bcl-xL inhibits por...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.34
更新日期:2016-02-25 00:00:00
abstract::Cellular senescence is the permanent arrest of cell cycle, physiologically related to aging and aging-associated diseases. Senescence is also recognized as a mechanism for limiting the regenerative potential of stem cells and to protect cells from cancer development. The senescence program is realized through autocrin...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2013.445
更新日期:2013-11-07 00:00:00
abstract::Our previous study showed that angiotensin II (Ang II) exposure diminished the interaction between nephrin and c-Abl, then c-Abl mediated SHIP2-Akt pathway in the process of podocyte injury in vivo and vitro. However, the relationship between nephrin and c-Abl was unknown. Recently, various studies showed that nephrin...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-017-0225-y
更新日期:2018-02-07 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. The mechanisms underlying NSCLC tumorigenesis are incompletely understood. Transfer RNA (tRNA) modification is emerging as a novel regulatory mechanism for carcinogenesis. However, the role of tRNA modification in NSCLC remains obsc...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2525-x
更新日期:2020-05-11 00:00:00
abstract::Reticular dysgenesis is a human severe combined immunodeficiency that is primarily characterized by profound neutropenia and lymphopenia. The condition is caused by mutations in the adenylate kinase 2 (AK2) gene, resulting in the loss of mitochondrial AK2 protein expression. AK2 regulates the homeostasis of mitochondr...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.211
更新日期:2015-08-13 00:00:00
abstract::The original version of this Article contained an error in Fig. 1, in which a number of incorrect fluorescence images were inadvertently incorporated into the panel. This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Cell death & disease
pub_type: 已发布勘误
doi:10.1038/s41419-019-1422-7
更新日期:2019-03-12 00:00:00
abstract::The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.347
更新日期:2016-02-18 00:00:00
abstract::Epidermal keratinocyte differentiation on the body surface is a carefully choreographed process that leads to assembly of a barrier that is essential for life. Perturbation of keratinocyte differentiation leads to disease. Activator protein 1 (AP1) transcription factors are key controllers of this process. We have sho...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2015.21
更新日期:2015-02-19 00:00:00
abstract::Breast cancer is the worldwide leading cause of cancer mortality in women. The majority of deaths from breast cancer arise from metastasis of local tumors. Cancer cells support their rapid proliferation by diverting metabolites into anabolic pathways, but during cancer metastasis, the proliferative program of invasive...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.27
更新日期:2016-03-24 00:00:00
abstract::The injurious consequences of ionizing radiation (IR) to normal human cells and the acquired radioresistance of cancer cells represent limitations to cancer radiotherapy. IR induces DNA damage response pathways that orchestrate cell cycle arrest, DNA repair or apoptosis such that irradiated cells are either repaired o...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.3
更新日期:2011-02-10 00:00:00
abstract::Members of the transforming growth factor-β (TGF-β) superfamily participate in numerous biological phenomena in multiple tissues, including in cell proliferation, differentiation, and migration. TGF-β superfamily proteins therefore have prominent roles in wound healing, fibrosis, bone formation, and carcinogenesis. Ho...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2011.114
更新日期:2011-12-01 00:00:00
abstract::15-Lipoxygenase-1 (15-LO-1) is involved in many pathological processes. The purpose of this study was to determine the potential role of 15-LO-1 in osteoarthritis (OA). The levels of 15-LO-1 expression were measured by western blotting and quantitative real-time PCR in articular cartilage from the OA rat models and OA...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2017.511
更新日期:2017-10-12 00:00:00
abstract::The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/cddis.2016.346
更新日期:2016-10-27 00:00:00
abstract::Poly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcripti...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2265-y
更新日期:2020-01-28 00:00:00
abstract::The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) is responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Several molecular mechanisms have been described for the pathogenicity of EHEC; however, the role of bacterial metabolism in the virulence of EHEC during infecti...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0423-2
更新日期:2018-03-07 00:00:00
abstract::Breast cancer is the leading cause of cancer-related death in women worldwide. Human epidermal growth factor receptor 2 (HER2)-positive subtype comprises 20% of sporadic breast cancers and is an aggressive disease. While targeted therapies have greatly improved its management, primary and acquired resistance remain a ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-021-03414-3
更新日期:2021-01-26 00:00:00
abstract::Bone marrow mesenchymal stem cells (MSCs) have demonstrated therapeutic effects for colitis through immunomodulation and anti-inflammation. However, whether MSC-derived exosomes possessed the similar function remains unclear. In present study, exosomes were isolated from control and IFN-γ-primed MSCs and was verified ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-02788-0
更新日期:2020-07-30 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with very poor prognosis. Therefore, it is important to fully understand the molecular mechanism underlying its occurrence and development. Pumilio RNA-binding family member 1 (PUM1) has been reported to function as an oncogene in ovarian cancer and nonsmall...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-1839-z
更新日期:2019-08-08 00:00:00
abstract::One of the significant challenges for chemotherapy is the appearance of resistance to compounds. Although several signaling pathways have been implicated in the development of Adriamycin (ADM) resistance, mechanisms involved in ADM-resistant osteosarcoma progression remain unknown. The present study attempted to illus...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-020-2573-2
更新日期:2020-05-13 00:00:00
abstract::Synapsin I is a phosphoprotein that coats the cytoplasmic side of synaptic vesicles and regulates their trafficking within nerve terminals. Autoantibodies against Syn I have been described in sera and cerebrospinal fluids of patients with numerous neurological diseases, including limbic encephalitis and clinically iso...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-019-2106-z
更新日期:2019-11-14 00:00:00
abstract::Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical angiogenic factor that is known to promote angiogenesis and metastasis in chondrosarcoma. It is unknown as to whether resistin ...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-1241-2
更新日期:2019-01-10 00:00:00
abstract::Although accumulating evidence has linked mesenchymal stem cells (MSCs) with tumor growth, the underlying mechanisms are poorly understood. Here, we demonstrated for the first time that human umbilical cord MSCs (hUCMSCs) dramatically increased the growth of lung adenocarcinoma (LUAD) cancer cells in a xenograft tumor...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0323-5
更新日期:2018-02-13 00:00:00
abstract::Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhib...
journal_title:Cell death & disease
pub_type: 杂志文章
doi:10.1038/s41419-018-0534-9
更新日期:2018-05-01 00:00:00