Abstract：
:In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin sulfate (CS) was used as the surface exposed ligand to achieve CD44 receptor mediated targeting of brain tumor. The developed CS-TNPs were characterized for particle size, zeta potential, entrapment efficiency and drug loading and evaluated by FTIR, DSC, XRD and TEM analysis. BBB (blood brain barrier) passage study using in vitro BBB model indicated that CS-TNPs were able to efficiently cross the BBB. Cell viability assay data demonstrated higher cytotoxicity of CS-TNPs as compared with pure TMZ. The CD44 receptor blocking assay and receptor poisoning assay in U87 MG cells confirmed the CD44 receptor and endocytosis-mediated (caveolae pathway) uptake of CS-TNPs. CS-TNPs were able to generate ROS in U87 MG cells. In vivo pharmacokinetic and biodistribution studies were performed in Wistar rats. In vivo results revealed significant enhancement in pharmacokinetic profile of CS-TNPs as compared with TMZ alone. Biodistribution results demonstrated higher accumulation of TMZ in the brain by CS-TNPs as compared with the pure drug that confirmed the brain targeting ability of nanoparticles. From all obtained results, it may be concluded that CS-TNPs are promising carrier to deliver TMZ to the brain for targeted therapy of brain tumor. Graphical abstract.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Kudarha RR,Sawant KKdoi
10.1007/s13346-020-00861-xsubject
Has Abstractpub_date
2020-10-07 00:00:00eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-020-00861-xpub_type
杂志文章abstract：:This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0538-0
更新日期：2018-10-01 00:00:00
abstract：:The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on in vitro drug relea...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00787-4
更新日期：2021-02-01 00:00:00
abstract：:The protective effects of synthetic lung surfactant Exosurf® (containing cetyl alcohol) against endotoxin-induced inflammation have been demonstrated in the literature. Thus, it is envisioned that nanoparticles loaded with quercetin (Q-NPs) prepared with binary mixtures of cetyl alcohol (CA) and Gelucire 44/14® (geluc...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0130-6
更新日期：2013-08-01 00:00:00
abstract：:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00852-y
更新日期：2020-09-23 00:00:00
abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00804-6
更新日期：2020-06-25 00:00:00
abstract：:Supersaturated drug delivery systems are commonly used to address the problems of poor aqueous solubility posed by most of the active pharmaceutical ingredients (APIs). However, the supersaturated systems are highly unstable due to their high free energy levels and demonstrate a tendency to precipitate. Understanding ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-019-00663-w
更新日期：2020-02-01 00:00:00
abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0137-z
更新日期：2014-06-01 00:00:00
abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0154-y
更新日期：2015-04-01 00:00:00
abstract：:The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical de...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00862-w
更新日期：2020-11-06 00:00:00
abstract：:This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-011-0026-2
更新日期：2011-06-01 00:00:00
abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0521-9
更新日期：2018-12-01 00:00:00
abstract：:Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these syste...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-015-0253-z
更新日期：2015-12-01 00:00:00
abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0541-5
更新日期：2018-10-01 00:00:00
abstract：:We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-15...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0421-4
更新日期：2017-12-01 00:00:00
abstract：:Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma s...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00727-2
更新日期：2020-06-01 00:00:00
abstract：:The objective of the present work was to develop polymeric nanoparticles of uricase and aceclofenac (NSAID) and to incorporate them into gel, for delivering drugs to synovial joints, for effective treatment of Gout. Nanoparticles containing uricase and aceclofenac were prepared by double emulsion solvent evaporation m...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-015-0219-1
更新日期：2015-06-01 00:00:00
abstract：:Psoriasis and atopic dermatitis are widespread pathologies with a need to improve their treatment. Topical administration of cyclosporine A (CyA) could be used if targeted to the skin, thus avoiding systemic levels. Unfortunately, CyA molecular weight and lipophilicity prevent its diffusion through human skin. Four no...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-019-00693-4
更新日期：2020-04-01 00:00:00
abstract：:Dry powder inhalers (DPIs) have been proposed as an alternative administration route for protein and peptide drugs. However, DPI particles are easy to aggregate due to the strong interactions between the particles, leading to poor aerosolization performance. In this study, fragmented particles containing octreotide ac...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0515-7
更新日期：2018-06-01 00:00:00
abstract：:The present research work summarises the development of an in situ gelling ophthalmic nanoemulsion of brinzolamide providing sustained release and prolonged therapeutic effect for the treatment of glaucoma. Nanoemulsions were prepared using castor oil, polyoxyl 35 castor oil and polysorbate 80 and with gellan gum as t...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-019-00697-0
更新日期：2020-04-01 00:00:00
abstract：:In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All c...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0577-6
更新日期：2019-02-01 00:00:00
abstract：:Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00846-w
更新日期：2020-12-01 00:00:00
abstract：:Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) mon...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0375-6
更新日期：2017-08-01 00:00:00
abstract：:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0063-5
更新日期：2012-04-01 00:00:00
abstract：:In bovine estrus synchronization, intravaginal devices made of silicone are used to administer exogenous progesterone with the aim of maintain plasmatic levels above 2 ng ml-1 during the treatment. After their use, devices must be discarded. There is an important concern on the environmental impact of the disposal of ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00717-4
更新日期：2020-10-01 00:00:00
abstract：:Drug nanocrystals have rapidly evolved into a mature drug delivery strategy in the last decade, with almost 16 products currently on the market. Several "top-down" technologies are available in the market for generation of nanocrystals. Despite several advantages, very few bottom-up technologies have been explored for...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-016-0286-y
更新日期：2016-08-01 00:00:00
abstract：:The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanopar...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00894-2
更新日期：2021-01-11 00:00:00
abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0533-5
更新日期：2018-10-01 00:00:00
abstract：:Lipid carrier-mediated transdermal drug delivery offers several advantages because it is non-irritating and non-toxic, provides effective control of drug release, and forms an adhesive film that hydrates the outer skin layers. However, to penetrate the deeper skin layers, these formulations need to overcome several ba...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0415-2
更新日期：2017-10-01 00:00:00
abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-020-00789-2
更新日期：2020-10-01 00:00:00
abstract：:In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-014-0214-y
更新日期：2015-02-01 00:00:00
