Abstract：
:In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All characterization tests were performed, as scanning electron microscopy and dynamic light scattering. The labeling process with 99mTc was performed using the direct labeling process. In vitro and in vivo assays were performed with animals and cells. The results showed that a spherical ethambutol nanoparticle with a size range of 280-300 nm was obtained. The stability test showed that the nanoparticles were well labeled with 99mTc (> 99.1%) and keep labeled over 24 h. The biodistribution assay showed that almost 18% of the nanoparticles were uptake by the lung in infected mice (male C57Bl/6) with Mycobacterium bovis BCG (4 × 105 CFU/cavity), corroborating its use as a nanodrug for tuberculosis imaging. The results for the cell assay corroborate its therapeutical effect. We developed and efficiently tested a new nanodrug that can be used for both imaging and therapy of tuberculosis, acting as a novel nanotheranostic.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Helal-Neto E,Rocha Pinto S,Portilho FL,da Costa MD,Pereira JX,Nigro F,Ricci-Junior E,Candéa ALP,das Graças Muller de Oliveira Henriques M,Santos-Oliveira Rdoi
10.1007/s13346-018-0577-6subject
Has Abstractpub_date
2019-02-01 00:00:00pages
97-105issue
1eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-018-0577-6journal_volume
9pub_type
杂志文章abstract：:Active targeted delivery of nanoparticle-encapsulated agents to tumor cells in vivo is expected to enhance therapeutic effect with significantly less non-specific toxicity. Active targeting is based on surface modification of nanoparticles with ligands that bind with extracellular targets and enhance payload delivery ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0178-3
更新日期：2013-12-01 00:00:00
abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0137-z
更新日期：2014-06-01 00:00:00
abstract：:Inhalation therapy of lipid-based carriers has great potential in direct target towards the root of respiratory diseases, which make them superior over other drug deliveries. With the successful entry of lipid carriers into the target cells, drugs can be absorbed in a sustained release manner and yield extended medici...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-018-0550-4
更新日期：2018-10-01 00:00:00
abstract：:The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on in vitro drug relea...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00787-4
更新日期：2021-02-01 00:00:00
abstract：:In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin sulfate (CS) was used as the surface exposed ligand to achieve CD44 receptor mediated targeting of brain tumor. The developed CS-TNPs were charac...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00861-x
更新日期：2020-10-07 00:00:00
abstract：:Lipid carrier-mediated transdermal drug delivery offers several advantages because it is non-irritating and non-toxic, provides effective control of drug release, and forms an adhesive film that hydrates the outer skin layers. However, to penetrate the deeper skin layers, these formulations need to overcome several ba...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0415-2
更新日期：2017-10-01 00:00:00
abstract：:Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery of polycapr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00816-2
更新日期：2020-12-01 00:00:00
abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-011-0034-2
更新日期：2011-06-01 00:00:00
abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0533-5
更新日期：2018-10-01 00:00:00
abstract：:A new PEGylated liposomal formulation containing both gemcitabine (GEM) and paclitaxel (PTX) was investigated in order to realize an innovative multidrug carrier (MDC) to test on human cancer cells. The MDC in question was realized by the liposome extrusion method. Photocorrelation spectroscopy was used for the physic...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-010-0007-x
更新日期：2011-02-01 00:00:00
abstract：:RNAi-based nanomedicine platforms (RNPs) have progressed from tools to study gene expression in vitro into clinical trials. Numerous RNPs strategies have been documented with an efficient ability to condense RNAi payloads and induce potent gene silencing. Moreover, some of these RNPs have been explored in various anim...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0158-7
更新日期：2014-02-01 00:00:00
abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-020-00789-2
更新日期：2020-10-01 00:00:00
abstract：:The objective of the present work was to formulate a novel stable delivery system which would not only overcome the solubility issue of silymarin, but also help to increase the therapeutic value by better permeation, anticancer action and reduced toxicity. This was envisaged through the recent developments in nanotech...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-016-0317-8
更新日期：2016-10-01 00:00:00
abstract：:The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical de...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00862-w
更新日期：2020-11-06 00:00:00
abstract：:In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-014-0214-y
更新日期：2015-02-01 00:00:00
abstract：:Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00713-8
更新日期：2020-06-01 00:00:00
abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0543-3
更新日期：2018-10-01 00:00:00
abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0521-9
更新日期：2018-12-01 00:00:00
abstract：:Supersaturated drug delivery systems are commonly used to address the problems of poor aqueous solubility posed by most of the active pharmaceutical ingredients (APIs). However, the supersaturated systems are highly unstable due to their high free energy levels and demonstrate a tendency to precipitate. Understanding ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-019-00663-w
更新日期：2020-02-01 00:00:00
abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0154-y
更新日期：2015-04-01 00:00:00
abstract：:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0063-5
更新日期：2012-04-01 00:00:00
abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0118-7
更新日期：2013-10-01 00:00:00
abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00853-x
更新日期：2020-09-11 00:00:00
abstract：:Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0372-9
更新日期：2017-06-01 00:00:00
abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-017-0391-6
更新日期：2017-12-01 00:00:00
abstract：:Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) mon...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0375-6
更新日期：2017-08-01 00:00:00
abstract：:Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00846-w
更新日期：2020-12-01 00:00:00
abstract：:Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precurs...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0070-6
更新日期：2012-10-01 00:00:00
abstract：:The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer model, in vitro and in...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0369-4
更新日期：2017-08-01 00:00:00
abstract：:Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0522-8
更新日期：2019-04-01 00:00:00
