Abstract：
:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was found to be a suitable cryoprotectant for lyophilization of Qu-NP, and antioxidant assays indicated that Qu-NP were able to retain the antioxidant property similar to that of free drug at equivalent concentration after formulation development. In vitro release study of Qu-NP showed a controlled release pattern of quercetin. An enhanced oral bioavailability (523% relative increase) was observed in pharmacokinetic study with a 6-day sustained release from Qu-NP as compared to quercetin suspension, which indicated the reduced dosing frequency. Efficacy in diabetic rats suggested that same dose of Qu-NP on every fifth day was sufficient to bring effect similar to daily dose of oral quercetin suspension, and the same effect was also observed for catalase and superoxide dismutase levels in pancreas and kidneys. Thus, the system offers an efficacious oral therapy with reduced dose and dosing frequency for treatment of diabetes and is hence patient compliant.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Chitkara D,Nikalaje SK,Mittal A,Chand M,Kumar Ndoi
10.1007/s13346-012-0063-5subject
Has Abstractpub_date
2012-04-01 00:00:00pages
112-23issue
2eissn
2190-393Xissn
2190-3948journal_volume
2pub_type
杂志文章abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...
journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2011-02-01 00:00:00
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journal_title：Drug delivery and translational research
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doi：10.1007/s13346-018-0521-9
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journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
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journal_title：Drug delivery and translational research
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更新日期：2013-10-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0088-9
更新日期：2012-08-01 00:00:00
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2020-02-01 00:00:00
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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abstract：:Dilauryl fluorescein (DLF) is a lipid soluble molecule that becomes fluorescent when lauric acid is removed by hydrolysis The purpose of these studies was to evaluate DLF as a potential probe for the function of reconstituted high-density lipoproteins (rHDL) as hydrophobic drug transport vehicles. The DLF containing r...
journal_title：Drug delivery and translational research
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更新日期：2011-04-01 00:00:00
abstract：:Trans -resveratrol (t-RES) is a natural polyphenolic compound with extensive therapeutic activities; however, its clinical application is circumscribed due to its poor solubility and low bioavailability. The purpose of this study was to prepare stable t-RES nanocrystals (t-RES-NCs) with different stabilizers to improv...
journal_title：Drug delivery and translational research
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