Abstract:
:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work focuses on the design and optimization of nanoemulsion (NE) gel formulation for the concurrent delivery of these three drugs. The NE system is consisting of oleic acid as oil phase, Tween 20 as surfactant, and PEG 200 as co-surfactant. The optimized formulation exhibited the droplet size 76.20 ± 1.67 nm, PDI of 0.12 ± 0.05, RI of 1.403 ± 0.007, and viscosity of 137.9 ± 4.07 mp. Carbopol 940 (0.5% w/v) was used as the gelling agent to prepare the NE gel which exhibited a good texture profile. The optimized formulation exhibited a higher % of growth inhibition on A-431 cells and demonstrated good anti-angiogenic activity in the HET-CAM test. Finally, in vivo studies in Balb/c mice model showed improved anti-psoriatic conditions which indicated that the triple natural bio-actives combination in nanoemulgel formulation is effective in the management of psoriasis.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Khatoon K,Ali A,Ahmad FJ,Hafeez Z,Rizvi MMA,Akhter S,Beg Sdoi
10.1007/s13346-020-00852-ysubject
Has Abstractpub_date
2020-09-23 00:00:00eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-020-00852-ypub_type
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journal_title:Drug delivery and translational research
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journal_title:Drug delivery and translational research
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journal_title:Drug delivery and translational research
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pub_type: 杂志文章
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doi:10.1007/s13346-014-0214-y
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journal_title:Drug delivery and translational research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s13346-015-0253-z
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pub_type: 杂志文章
doi:10.1007/s13346-018-0491-y
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s13346-013-0130-6
更新日期:2013-08-01 00:00:00
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journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-017-0437-9
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journal_title:Drug delivery and translational research
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pub_type: 杂志文章,评审
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journal_title:Drug delivery and translational research
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abstract::The cutaneous penetration of acyclovir from the conventional topical formulations such as cream and ointments is poor due to low water solubility and low octanol buffer partition coefficient of the drug. The present investigation was aimed to prepare acyclovir-loaded microsponge-based emulgel to improve its topical de...
journal_title:Drug delivery and translational research
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journal_title:Drug delivery and translational research
pub_type: 杂志文章,评审
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abstract::Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...
journal_title:Drug delivery and translational research
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journal_title:Drug delivery and translational research
pub_type: 杂志文章
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journal_title:Drug delivery and translational research
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
abstract::Trans -resveratrol (t-RES) is a natural polyphenolic compound with extensive therapeutic activities; however, its clinical application is circumscribed due to its poor solubility and low bioavailability. The purpose of this study was to prepare stable t-RES nanocrystals (t-RES-NCs) with different stabilizers to improv...
journal_title:Drug delivery and translational research
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