Abstract：
:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were extruded with 30% drug loading. The physical state of QF in extruded mini-matrices was characterized using differential scanning calorimetry, X-ray powder diffraction, and confocal Raman microscopy. The release-controlled ability of PVP VA64 was investigated and compared with that of xanthan gum, crospovidone, and low-substituted hydroxypropylcellulose. The influences of PVP VA64 content and processing temperature on QF release behavior and mechanism were also studied. The results indicated QF dispersed as the crystalline state in all mini-matrices. The release of QF from EC was very slow as only 4% QF was released in 24 h. PVP VA64 exhibited the best ability to enhance the drug release as compared with other three release-modifiers. The drug release increased to 50-100% in 24 h with the addition of 20-40% PVP VA64. Increasing processing temperature slightly slowed down the drug release by decreasing free volume and pore size. The release kinetics showed good fit with the Ritger-Peppas model. The values of release exponent (n) increased as PVP VA64 is added (0.14 for pure EC, 0.41 for 20% PVP VA64, and 0.61 for 40% PVP VA64), revealing that the addition of PVP VA64 enhanced the erosion mechanism. This work presented a new polymer blend system of EC with PVP VA64 for sustained-release prepared via HME.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Li Y,Lu M,Wu Cdoi
10.1007/s13346-017-0437-9subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1670-1678issue
6eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-017-0437-9journal_volume
8pub_type
杂志文章abstract：:Dilauryl fluorescein (DLF) is a lipid soluble molecule that becomes fluorescent when lauric acid is removed by hydrolysis The purpose of these studies was to evaluate DLF as a potential probe for the function of reconstituted high-density lipoproteins (rHDL) as hydrophobic drug transport vehicles. The DLF containing r...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-010-0012-0
更新日期：2011-04-01 00:00:00
abstract：:The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-016-0352-5
更新日期：2017-04-01 00:00:00
abstract：:Bovine mastitis caused by bacterial infections of the mammary gland (udder) of dairy cows is a costly pathology for the dairy industry due to direct and indirect losses in production. Penethamate, a pro-drug of benzylpenicillin, is used by intramuscular injection (IM). The existing products are powders which must be r...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0388-1
更新日期：2018-04-01 00:00:00
abstract：:Dry powder inhalers (DPIs) have been proposed as an alternative administration route for protein and peptide drugs. However, DPI particles are easy to aggregate due to the strong interactions between the particles, leading to poor aerosolization performance. In this study, fragmented particles containing octreotide ac...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0515-7
更新日期：2018-06-01 00:00:00
abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-012-0118-7
更新日期：2013-10-01 00:00:00
abstract：:Osteoporosis, due to its prevalence worldwide, is a serious health problem. Topical administration of quercetin, a phytoestrogen, in the form of deformable transfersomes, could be used to treat osteoporosis to overcome its low oral solubility and bioavailability. Formulation process of transfersomes was screened by fr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00708-5
更新日期：2020-10-01 00:00:00
abstract：:Orthopedic tissue regeneration would benefit the aging population or patients with degenerative bone and cartilage diseases, especially osteoporosis and osteoarthritis. Despite progress in surgical and pharmacological interventions, new regenerative approaches are needed to meet the challenge of creating bone and arti...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-015-0266-7
更新日期：2016-04-01 00:00:00
abstract：:Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0522-8
更新日期：2019-04-01 00:00:00
abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0137-z
更新日期：2014-06-01 00:00:00
abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0541-5
更新日期：2018-10-01 00:00:00
abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-020-00789-2
更新日期：2020-10-01 00:00:00
abstract：:Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma s...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00727-2
更新日期：2020-06-01 00:00:00
abstract：:Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery of polycapr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00816-2
更新日期：2020-12-01 00:00:00
abstract：:The objective of the present work was to formulate a novel stable delivery system which would not only overcome the solubility issue of silymarin, but also help to increase the therapeutic value by better permeation, anticancer action and reduced toxicity. This was envisaged through the recent developments in nanotech...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-016-0317-8
更新日期：2016-10-01 00:00:00
abstract：:In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-014-0214-y
更新日期：2015-02-01 00:00:00
abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0521-9
更新日期：2018-12-01 00:00:00
abstract：:The protective effects of synthetic lung surfactant Exosurf® (containing cetyl alcohol) against endotoxin-induced inflammation have been demonstrated in the literature. Thus, it is envisioned that nanoparticles loaded with quercetin (Q-NPs) prepared with binary mixtures of cetyl alcohol (CA) and Gelucire 44/14® (geluc...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0130-6
更新日期：2013-08-01 00:00:00
abstract：:The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanopar...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00894-2
更新日期：2021-01-11 00:00:00
abstract：:Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0372-9
更新日期：2017-06-01 00:00:00
abstract：:Curcumin (CUR), a natural polyphenolic compound, is considered as one of the most potential candidates against Alzheimer disease (AD) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. Poor physicochemical profile and oral bioavailability (BA) are the major contributors ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0570-0
更新日期：2018-10-01 00:00:00
abstract：:The bioadhesive hollow microspheres of riboflavin were developed as a site-specific gastroretentive system to prolong the residence time of drug in the stomach and, consequently, to enhance the bioavailability. Hollow microspheres (M1-M9) prepared by the emulsion solvent diffusion method using ethyl cellulose and Eudr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0143-1
更新日期：2013-06-01 00:00:00
abstract：:Simvastatin (SIM) is a commonly used cholesterol-lowering drug that can reduce the risk of major cardiovascular events. However, due to its poor intrinsic water solubility, the drug is poorly absorbed from the gastrointestinal tract and exhibits a low oral bioavailability of approximately 5%. The aim of this study was...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00853-x
更新日期：2020-09-11 00:00:00
abstract：:RNAi-based nanomedicine platforms (RNPs) have progressed from tools to study gene expression in vitro into clinical trials. Numerous RNPs strategies have been documented with an efficient ability to condense RNAi payloads and induce potent gene silencing. Moreover, some of these RNPs have been explored in various anim...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0158-7
更新日期：2014-02-01 00:00:00
abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0543-3
更新日期：2018-10-01 00:00:00
abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0514-8
更新日期：2018-06-01 00:00:00
abstract：:The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on in vitro drug relea...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00787-4
更新日期：2021-02-01 00:00:00
abstract：:This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-011-0026-2
更新日期：2011-06-01 00:00:00
abstract：:We previously showed that the combination of the non-nucleoside reverse transcriptase inhibitor (NNRTI) MIV-150 with zinc acetate (ZA) formulated in a carrageenan (CG; MZC) gel provided macaques significant protection against vaginal simian-human immunodeficiency virus-RT (SHIV-RT) challenge, better than either MIV-15...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0421-4
更新日期：2017-12-01 00:00:00
abstract：:The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0491-y
更新日期：2019-04-01 00:00:00
abstract：:Drug nanocrystals have rapidly evolved into a mature drug delivery strategy in the last decade, with almost 16 products currently on the market. Several "top-down" technologies are available in the market for generation of nanocrystals. Despite several advantages, very few bottom-up technologies have been explored for...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-016-0286-y
更新日期：2016-08-01 00:00:00
