Abstract：
:Bovine mastitis caused by bacterial infections of the mammary gland (udder) of dairy cows is a costly pathology for the dairy industry due to direct and indirect losses in production. Penethamate, a pro-drug of benzylpenicillin, is used by intramuscular injection (IM). The existing products are powders which must be reconstituted in water-for-injection and this presents difficulties in the field. Penethamate is too unstable to be formulated as an aqueous formulation but a chemically stable suspension formulation was possible in certain oils; however, some literature suggests that such formulations would have unacceptable prolonged release. The translational research proceeded iteratively from lab to the target species, rather than via laboratory animal trials. Pilot studies in cows suggested that some oily suspensions would give concentrations of benzylpenicillin, (in both blood and milk) comparable with those of the reconstituted product. A physicochemical screen and a low level in vitro-in vivo correlation (IVIVC) was cautiously used to guide selection of formulations for subsequent animal trials which have resulted in a lead formulation for good laboratory practices (GLP), good clinical practices (GCP) studies.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Tucker IG,Jain R,Alawi F,Nanjan K,Bork Odoi
10.1007/s13346-017-0388-1subject
Has Abstractpub_date
2018-04-01 00:00:00pages
317-328issue
2eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-017-0388-1journal_volume
8pub_type
杂志文章abstract：:The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
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journal_title：Drug delivery and translational research
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abstract：:In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...
journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2018-12-01 00:00:00
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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