Abstract:
:Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the form of oils on wound healing. Linseed (LO), evening primrose (EPO), and olive oils (OO) rich in omega-3, omega-6, and omega-9 fatty acids were formulated into emulsions and were topically applied on rats with excision wounds. All omega-3-, omega-6-, and omega-9-rich oil formulations were found to accelerate wound closure compared to untreated, with significant improvement (p < 0.05) being observed at day 14. EPO induced early deposition of collagen as evaluated by Masson trichrome staining that correlated well with the hydroxyproline content assay, with the highest level at days 3 and 7. Vascular endothelial growth factor (VEGF) showed greater amount of new microvasculature formed in the EPO-treated group, while moderate improvement occurs in the LO and OO groups. EPO increased both the expression of proinflammatory cytokines and growth factors in the early stage of healing and declined at the later stage of healing. LO modulates the proinflammatory cytokines and chemokine but did not affect the growth factors. In contrast, OO induced the expression of growth factors rather than proinflammatory cytokines. These data suggest that LO, EPO, and OO emulsions promote wound healing but they accomplish this by different mechanisms.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Ishak WMW,Katas H,Yuen NP,Abdullah MA,Zulfakar MHdoi
10.1007/s13346-018-0522-8subject
Has Abstractpub_date
2019-04-01 00:00:00pages
418-433issue
2eissn
2190-393Xissn
2190-3948pii
10.1007/s13346-018-0522-8journal_volume
9pub_type
杂志文章abstract::Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0541-5
更新日期:2018-10-01 00:00:00
abstract::Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0543-3
更新日期:2018-10-01 00:00:00
abstract::Curcumin (CUR), a natural polyphenolic compound, is considered as one of the most potential candidates against Alzheimer disease (AD) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. Poor physicochemical profile and oral bioavailability (BA) are the major contributors ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0570-0
更新日期:2018-10-01 00:00:00
abstract::This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0538-0
更新日期:2018-10-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF), a growth factor expressed in the central nervous system, promotes the survival of both dopaminergic and motor neurons, making it a promising candidate for neurodegenerative disease therapy. Although GDNF is currently being evaluated in clinical trials for the treatme...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-013-0189-0
更新日期:2014-04-01 00:00:00
abstract::The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0491-y
更新日期:2019-04-01 00:00:00
abstract::The involvement of recent technologies, such as nanotechnology and three-dimensional printing (3DP), in drug delivery has become the utmost importance for effective and safe delivery of potent therapeutics, and thus, recent advancement for oral drug delivery through 3DP technology has been expanded. The use of compute...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00737-0
更新日期:2020-08-01 00:00:00
abstract::The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-013-0154-y
更新日期:2015-04-01 00:00:00
abstract::Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0480-1
更新日期:2019-04-01 00:00:00
abstract::Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00804-6
更新日期:2020-06-25 00:00:00
abstract::A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-013-0137-z
更新日期:2014-06-01 00:00:00
abstract::The objective of this research was to develop polymeric micellar formulations of inhibitors of signal transducer and activator of transcription 3 (STAT3) dimerization, i.e., S3I-1757 and S3I-201, and evaluate the activity of successful formulations in B16-F10 melanoma, a STAT3 hyperactive cancer model, in vitro and in...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-017-0369-4
更新日期:2017-08-01 00:00:00
abstract::The study focused on formulation of carmellose sodium hydrogels and nonionic microemulsions with 5% and 10% of levetiracetam and investigation of drug concentration influence on their physicochemical characteristics and in-use stability as well as influence of drug concentration and carrier type on in vitro drug relea...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00787-4
更新日期:2021-02-01 00:00:00
abstract::Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these syste...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-015-0253-z
更新日期:2015-12-01 00:00:00
abstract::This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-011-0026-2
更新日期:2011-06-01 00:00:00
abstract::The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanopar...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00894-2
更新日期:2021-01-11 00:00:00
abstract::Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical formulations. As PEO is sensitive to thermal oxidation, it is suscepti...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-016-0344-5
更新日期:2017-02-01 00:00:00
abstract::Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-012-0063-5
更新日期:2012-04-01 00:00:00
abstract::Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00846-w
更新日期:2020-12-01 00:00:00
abstract::In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章,评审
doi:10.1007/s13346-016-0330-y
更新日期:2016-12-01 00:00:00
abstract::The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-018-0514-8
更新日期:2018-06-01 00:00:00
abstract::Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-012-0118-7
更新日期:2013-10-01 00:00:00
abstract::Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...
journal_title:Drug delivery and translational research
pub_type: 杂志文章,评审
doi:10.1007/s13346-017-0391-6
更新日期:2017-12-01 00:00:00
abstract::Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-017-0372-9
更新日期:2017-06-01 00:00:00
abstract::Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00713-8
更新日期:2020-06-01 00:00:00
abstract::Osteoporosis, due to its prevalence worldwide, is a serious health problem. Topical administration of quercetin, a phytoestrogen, in the form of deformable transfersomes, could be used to treat osteoporosis to overcome its low oral solubility and bioavailability. Formulation process of transfersomes was screened by fr...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00708-5
更新日期:2020-10-01 00:00:00
abstract::In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin sulfate (CS) was used as the surface exposed ligand to achieve CD44 receptor mediated targeting of brain tumor. The developed CS-TNPs were charac...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00861-x
更新日期:2020-10-07 00:00:00
abstract::In this work, we studied the effect of gamma irradiation on nano-bioactive glass (NBG) structure, bioactivity, drug loading efficiency, and drug release kinetic. Gamma irradiation was mainly introduced as a safe and cheap method to tailor the drug loading and release efficiencies. NBG was investigated before and after...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-014-0214-y
更新日期:2015-02-01 00:00:00
abstract::Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-020-00852-y
更新日期:2020-09-23 00:00:00
abstract::Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precurs...
journal_title:Drug delivery and translational research
pub_type: 杂志文章
doi:10.1007/s13346-012-0070-6
更新日期:2012-10-01 00:00:00