Micellar nano-carriers for the delivery of STAT3 dimerization inhibitors to melanoma.

abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...

journal_title：Drug delivery and translational research

authors： Lykins WR,Luecke E,Johengen D,van der Straten A,Desai TA

更新日期：2017-12-01 00:00:00

abstract：:In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...

journal_title：Drug delivery and translational research

authors： Rönkkö S,Vellonen KS,Järvinen K,Toropainen E,Urtti A

更新日期：2016-12-01 00:00:00

abstract：:This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...

journal_title：Drug delivery and translational research

authors： Pereira LE,Singletary T,Martin A,Dinh CT,Deyounks F,Holder A,McNicholl J,Buckheit KW,Buckheit RW Jr,Ham A,Katz DF,Smith JM

更新日期：2018-10-01 00:00:00

abstract：:Inhalation therapy of lipid-based carriers has great potential in direct target towards the root of respiratory diseases, which make them superior over other drug deliveries. With the successful entry of lipid carriers into the target cells, drugs can be absorbed in a sustained release manner and yield extended medici...

journal_title：Drug delivery and translational research

authors： Ngan CL,Asmawi AA

更新日期：2018-10-01 00:00:00

abstract：:Nanoparticulate systems have emerged as prevalent drug delivery systems over the past few decades. These delivery systems (such as liposomes, emulsions, nanocrystals, and polymeric nanocarriers) have been extensively used to improve bioavailability, prolong pharmacological effects, achieve targeted drug delivery, as w...

journal_title：Drug delivery and translational research

authors： Shen J,Burgess DJ

更新日期：2013-10-01 00:00:00

abstract：:Osteoporosis, due to its prevalence worldwide, is a serious health problem. Topical administration of quercetin, a phytoestrogen, in the form of deformable transfersomes, could be used to treat osteoporosis to overcome its low oral solubility and bioavailability. Formulation process of transfersomes was screened by fr...

journal_title：Drug delivery and translational research

authors： Pandit AP,Omase SB,Mute VM

更新日期：2020-10-01 00:00:00

abstract：:Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...

journal_title：Drug delivery and translational research

authors： Ferreira NN,Granja S,Boni FI,Ferreira LMB,Reis RM,Baltazar F,Gremião MPD

更新日期：2020-06-01 00:00:00

abstract：:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were e...

journal_title：Drug delivery and translational research

authors： Li Y,Lu M,Wu C

更新日期：2018-12-01 00:00:00

abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...

journal_title：Drug delivery and translational research

authors： Lee JH,Lee YJ,Cho HJ,Kim DW,Shin H

更新日期：2015-04-01 00:00:00

abstract：:Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...

journal_title：Drug delivery and translational research

authors： Surwase SS,Munot NM,Idage BB,Idage SB

更新日期：2017-06-01 00:00:00

abstract：:Dry powder inhalers (DPIs) have been proposed as an alternative administration route for protein and peptide drugs. However, DPI particles are easy to aggregate due to the strong interactions between the particles, leading to poor aerosolization performance. In this study, fragmented particles containing octreotide ac...

journal_title：Drug delivery and translational research

authors： Hou A,Li L,Huang Y,Singh V,Zhu C,Pan X,Quan G,Wu C

更新日期：2018-06-01 00:00:00

abstract：:Dilauryl fluorescein (DLF) is a lipid soluble molecule that becomes fluorescent when lauric acid is removed by hydrolysis The purpose of these studies was to evaluate DLF as a potential probe for the function of reconstituted high-density lipoproteins (rHDL) as hydrophobic drug transport vehicles. The DLF containing r...

journal_title：Drug delivery and translational research

authors： McConathy WJ,Paranjape S,Mooberry L,Buttreddy S,Nair M,Lacko AG

更新日期：2011-04-01 00:00:00

abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...

journal_title：Drug delivery and translational research

authors： Sharma AK,Prasher P,Aljabali AA,Mishra V,Gandhi H,Kumar S,Mutalik S,Chellappan DK,Tambuwala MM,Dua K,Kapoor DN

更新日期：2020-10-01 00:00:00

abstract：:Psoriasis and atopic dermatitis are widespread pathologies with a need to improve their treatment. Topical administration of cyclosporine A (CyA) could be used if targeted to the skin, thus avoiding systemic levels. Unfortunately, CyA molecular weight and lipophilicity prevent its diffusion through human skin. Four no...

journal_title：Drug delivery and translational research

authors： Carreras JJ,Tapia-Ramirez WE,Sala A,Guillot AJ,Garrigues TM,Melero A

更新日期：2020-04-01 00:00:00

abstract：:Curcumin (CUR), a natural polyphenolic compound, is considered as one of the most potential candidates against Alzheimer disease (AD) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. Poor physicochemical profile and oral bioavailability (BA) are the major contributors ...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Li J,Chen C,Shan Z,Cao X,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00

abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...

journal_title：Drug delivery and translational research

authors： Salama RO,Young PM,Traini D

更新日期：2014-06-01 00:00:00

abstract：:Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained de...

journal_title：Drug delivery and translational research

authors： Dixon P,Ghosh T,Mondal K,Konar A,Chauhan A,Hazra S

更新日期：2018-10-01 00:00:00

abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...

journal_title：Drug delivery and translational research

authors： Jain A,Kaur R,Beg S,Kushwah V,Jain S,Singh B

更新日期：2018-06-01 00:00:00

abstract：:This review focuses on clinical application of intravaginal formulations containing nitric oxide (NO). Poly(D,L-lactic acid-co-glycolic acid)-based microparticles or nanoparticles encapsulated with nitric oxide prodrugs, such as diethylenetriamine diazeniumdiolate and S-nitrosoglutathione, have been developed for the ...

journal_title：Drug delivery and translational research

authors： Lee CH

更新日期：2011-06-01 00:00:00

abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...

journal_title：Drug delivery and translational research

authors： Turpin JA

更新日期：2011-06-01 00:00:00

abstract：:The bioadhesive hollow microspheres of riboflavin were developed as a site-specific gastroretentive system to prolong the residence time of drug in the stomach and, consequently, to enhance the bioavailability. Hollow microspheres (M1-M9) prepared by the emulsion solvent diffusion method using ethyl cellulose and Eudr...

journal_title：Drug delivery and translational research

authors： Upadhyay MS,Pathak K

更新日期：2013-06-01 00:00:00

abstract：:The objective of the present work was to develop polymeric nanoparticles of uricase and aceclofenac (NSAID) and to incorporate them into gel, for delivering drugs to synovial joints, for effective treatment of Gout. Nanoparticles containing uricase and aceclofenac were prepared by double emulsion solvent evaporation m...

journal_title：Drug delivery and translational research

authors： Tiwari S,Dwivedi H,Kymonil KM,Saraf SA

更新日期：2015-06-01 00:00:00

abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...

journal_title：Drug delivery and translational research

authors： Soni MP,Mahajan MV,Dhumal RV,Bhagat S,Tiwari D,Gaikwad RV,Samad A,Devarajan PV,Vanage GR

更新日期：2013-10-01 00:00:00

abstract：:Curcumin, resveratrol, and thymoquinone are the potential natural bio-actives reported with good anti-psoriatic activity. However, poor aqueous solubility and limited skin permeation of these natural bio-actives hinder their effective delivery and potential therapeutic outcome. In this regard, current research work fo...

journal_title：Drug delivery and translational research

authors： Khatoon K,Ali A,Ahmad FJ,Hafeez Z,Rizvi MMA,Akhter S,Beg S

更新日期：2020-09-23 00:00:00

abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...

journal_title：Drug delivery and translational research

authors： Hanning SM,Matiz S,Krasser K,Orlu M,Dodoo C,Gaisford S,Tuleu C

更新日期：2020-06-25 00:00:00

abstract：:The involvement of recent technologies, such as nanotechnology and three-dimensional printing (3DP), in drug delivery has become the utmost importance for effective and safe delivery of potent therapeutics, and thus, recent advancement for oral drug delivery through 3DP technology has been expanded. The use of compute...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Fern JLC,Kee ATK,Kou J,Jing JLJ,Her HC,Yong HS,Ming HC,Bhattamisra SK,Gorain B

更新日期：2020-08-01 00:00:00

abstract：:Orthopedic tissue regeneration would benefit the aging population or patients with degenerative bone and cartilage diseases, especially osteoporosis and osteoarthritis. Despite progress in surgical and pharmacological interventions, new regenerative approaches are needed to meet the challenge of creating bone and arti...

journal_title：Drug delivery and translational research

authors： Jeon OH,Elisseeff J

更新日期：2016-04-01 00:00:00

abstract：:Polyelectrolyte nanoparticle constructs (NPs) comprising salmon calcitonin (sCT), chitosan (CS), and hyaluronic acid (HA) were previously established as having anti-inflammatory potential when injected via the intra-articular (i.a.) route to a mouse model. We attempted to translate the formulation to a large animal mo...

journal_title：Drug delivery and translational research

authors： Sladek S,Kearney C,Crean D,Brama PAJ,Tajber L,Fawcett K,Labberte MC,Leggett B,Brayden DJ

更新日期：2018-10-01 00:00:00

abstract：:The promise of RNA interference (RNAi) technology in cancer therapeutics aims to deliver small interfering RNA (siRNA) for silencing of gene expression in cell type-specific pathway. However, the challenge for the delivery of stable siRNA is hindered by an immune-hostile tumor microenvironment and physiological barrie...

journal_title：Drug delivery and translational research

authors： Mishra DK,Balekar N,Mishra PK

更新日期：2017-04-01 00:00:00

abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Song Y,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00