Treatment of blood flow abnormality using mucosal delivery of nitric oxide.

abstract：:This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...

journal_title：Drug delivery and translational research

authors： Pereira LE,Singletary T,Martin A,Dinh CT,Deyounks F,Holder A,McNicholl J,Buckheit KW,Buckheit RW Jr,Ham A,Katz DF,Smith JM

更新日期：2018-10-01 00:00:00

abstract：:Nanoparticles, being small (<1,000 nm) in size, provide high surface area-to-volume ratio as compared with the bulk materials which increase the concern about their potential toxicities. The present investigation was undertaken to evaluate the genotoxic potential of asymmetric lipid polymer hybrid nanoparticles of dox...

journal_title：Drug delivery and translational research

authors： Soni MP,Mahajan MV,Dhumal RV,Bhagat S,Tiwari D,Gaikwad RV,Samad A,Devarajan PV,Vanage GR

更新日期：2013-10-01 00:00:00

abstract：:The objective of the present work was to develop polymeric nanoparticles of uricase and aceclofenac (NSAID) and to incorporate them into gel, for delivering drugs to synovial joints, for effective treatment of Gout. Nanoparticles containing uricase and aceclofenac were prepared by double emulsion solvent evaporation m...

journal_title：Drug delivery and translational research

authors： Tiwari S,Dwivedi H,Kymonil KM,Saraf SA

更新日期：2015-06-01 00:00:00

abstract：:RNAi-based nanomedicine platforms (RNPs) have progressed from tools to study gene expression in vitro into clinical trials. Numerous RNPs strategies have been documented with an efficient ability to condense RNAi payloads and induce potent gene silencing. Moreover, some of these RNPs have been explored in various anim...

journal_title：Drug delivery and translational research

authors： Landesman-Milo D,Peer D

更新日期：2014-02-01 00:00:00

abstract：:Access to medicines, including their availability and affordability, is a major public health challenge worldwide. This research aimed to characterise rectal formulations containing amoxicillin for the treatment of pneumonia in children under five, as an accessible alternative to existing formulations. Lipophilic Supp...

journal_title：Drug delivery and translational research

authors： Hanning SM,Matiz S,Krasser K,Orlu M,Dodoo C,Gaisford S,Tuleu C

更新日期：2020-06-25 00:00:00

abstract：:Hydrophilic matrix systems are currently some of the most widely used drug delivery systems for controlled-release oral dosage forms. Amongst a variety of polymers, polyethylene oxide (PEO) is considered an important material used in pharmaceutical formulations. As PEO is sensitive to thermal oxidation, it is suscepti...

journal_title：Drug delivery and translational research

authors： Shojaee S,Nokhodchi A,Maniruzzaman M

更新日期：2017-02-01 00:00:00

abstract：:Hydrogel-forming microneedle array patches (MAPs) have been proposed as viable clinical tools for patient monitoring purposes, providing an alternative to traditional methods of sample acquisition, such as venepuncture and intradermal sampling. They are also undergoing investigation in the management of non-melanoma s...

journal_title：Drug delivery and translational research

authors： Al-Kasasbeh R,Brady AJ,Courtenay AJ,Larrañeta E,McCrudden MTC,O'Kane D,Liggett S,Donnelly RF

更新日期：2020-06-01 00:00:00

abstract：:Quercetin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Qu-NP) were prepared by emulsion-diffusion-evaporation method and characterized as 179.9 ± 11.2 nm in size with 0.128 as polydispersity index, more than 86% drug entrapment efficiency, and zeta potential was -6.06 ± 1.51 mV. D-Trehalose (5% w/v) was ...

journal_title：Drug delivery and translational research

authors： Chitkara D,Nikalaje SK,Mittal A,Chand M,Kumar N

更新日期：2012-04-01 00:00:00

abstract：:The objective of the present work was to formulate a novel stable delivery system which would not only overcome the solubility issue of silymarin, but also help to increase the therapeutic value by better permeation, anticancer action and reduced toxicity. This was envisaged through the recent developments in nanotech...

journal_title：Drug delivery and translational research

authors： Singh P,Singh M,Kanoujia J,Arya M,Saraf SK,Saraf SA

更新日期：2016-10-01 00:00:00

abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...

journal_title：Drug delivery and translational research

authors： Turpin JA

更新日期：2011-06-01 00:00:00

abstract：:Lipid-based liquid crystalline (LC) systems have the potential to sustain the oral absorption of poorly water-soluble drugs in vivo, facilitating slow drug release from their complex internal structure. To further evaluate the dynamic relationship between gastric retention and sustained drug absorption for these syste...

journal_title：Drug delivery and translational research

authors： Pham AC,Nguyen TH,Nowell CJ,Graham B,Boyd BJ

更新日期：2015-12-01 00:00:00

abstract：:Nanoparticulate systems have emerged as prevalent drug delivery systems over the past few decades. These delivery systems (such as liposomes, emulsions, nanocrystals, and polymeric nanocarriers) have been extensively used to improve bioavailability, prolong pharmacological effects, achieve targeted drug delivery, as w...

journal_title：Drug delivery and translational research

authors： Shen J,Burgess DJ

更新日期：2013-10-01 00:00:00

abstract：:Bovine mastitis caused by bacterial infections of the mammary gland (udder) of dairy cows is a costly pathology for the dairy industry due to direct and indirect losses in production. Penethamate, a pro-drug of benzylpenicillin, is used by intramuscular injection (IM). The existing products are powders which must be r...

journal_title：Drug delivery and translational research

authors： Tucker IG,Jain R,Alawi F,Nanjan K,Bork O

更新日期：2018-04-01 00:00:00

abstract：:The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA ...

journal_title：Drug delivery and translational research

authors： Sheshala R,Hong GC,Yee WP,Meka VS,Thakur RRS

更新日期：2019-04-01 00:00:00

abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...

journal_title：Drug delivery and translational research

authors： Guionet A,Moosavi Nejad S,Teissié J,Sakugawa T,Katsuki S,Akiyama H,Hosseini H

更新日期：2018-10-01 00:00:00

abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...

journal_title：Drug delivery and translational research

authors： Fritz HF,Ortiz AC,Velaga SP,Morales JO

更新日期：2018-12-01 00:00:00

abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...

journal_title：Drug delivery and translational research

authors： Salama RO,Young PM,Traini D

更新日期：2014-06-01 00:00:00

abstract：:Combination therapy that uses multiple drugs against different molecular targets should be considered as interesting alternatives for treating complex diseases such as glioblastoma (GBM). Drugs like alpha-cyano-4-hydroxycinnamic acid (CHC) and the monoclonal antibody cetuximab (CTX) are already explored for their capa...

journal_title：Drug delivery and translational research

authors： Ferreira NN,Granja S,Boni FI,Ferreira LMB,Reis RM,Baltazar F,Gremião MPD

更新日期：2020-06-01 00:00:00

abstract：:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were e...

journal_title：Drug delivery and translational research

authors： Li Y,Lu M,Wu C

更新日期：2018-12-01 00:00:00

abstract：:The bioadhesive hollow microspheres of riboflavin were developed as a site-specific gastroretentive system to prolong the residence time of drug in the stomach and, consequently, to enhance the bioavailability. Hollow microspheres (M1-M9) prepared by the emulsion solvent diffusion method using ethyl cellulose and Eudr...

journal_title：Drug delivery and translational research

authors： Upadhyay MS,Pathak K

更新日期：2013-06-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF), a growth factor expressed in the central nervous system, promotes the survival of both dopaminergic and motor neurons, making it a promising candidate for neurodegenerative disease therapy. Although GDNF is currently being evaluated in clinical trials for the treatme...

journal_title：Drug delivery and translational research

authors： Agbay A,Mohtaram NK,Willerth SM

更新日期：2014-04-01 00:00:00

abstract：:Nanotechnology is expected to revolutionize existing drug delivery. Many nanostructured systems have been employed for drug delivery and yielded some promising results. Solid lipid nanoparticles (SLN) have been looked at as a potential drug carrier system since last two decades. SLN do not show biotoxicity as they are...

journal_title：Drug delivery and translational research

authors： Mishra DK,Dhote V,Bhatnagar P,Mishra PK

更新日期：2012-08-01 00:00:00

abstract：:Over the past two decades, polymersomes have been widely investigated for the delivery of diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric vesicles, which are prepared using amphiphilic block polymers of different molecular weights. The use of high molecular weight amphiphilic cop...

journal_title：Drug delivery and translational research

authors： Sharma AK,Prasher P,Aljabali AA,Mishra V,Gandhi H,Kumar S,Mutalik S,Chellappan DK,Tambuwala MM,Dua K,Kapoor DN

更新日期：2020-10-01 00:00:00

abstract：:Curcumin (CUR) is considered as one of the most bioactive molecules ever discovered from nature due to its proven anti-inflammatory and antioxidant in both preclinical and clinical studies. Despite its proven safety and efficacy, the clinical translation of CUR into a useful therapeutic agent is still limited due to i...

journal_title：Drug delivery and translational research

authors： Parikh A,Kathawala K,Song Y,Zhou XF,Garg S

更新日期：2018-10-01 00:00:00

abstract：:In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All c...

journal_title：Drug delivery and translational research

authors： Helal-Neto E,Rocha Pinto S,Portilho FL,da Costa MD,Pereira JX,Nigro F,Ricci-Junior E,Candéa ALP,das Graças Muller de Oliveira Henriques M,Santos-Oliveira R

更新日期：2019-02-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronically relapsing eczematous skin disease characterised by frequent episodes of rashes, severe flares, and inflammation. Till date, there is no absolute therapy for the treatment of AD; however, topical corticosteroids (TCs) are the majorly prescribed class of drugs for the management o...

journal_title：Drug delivery and translational research

authors： Pandey M,Choudhury H,Gunasegaran TAP,Nathan SS,Md S,Gorain B,Tripathy M,Hussain Z

更新日期：2019-04-01 00:00:00

abstract：:Intranasal administration of mucus-penetrating nanoparticles is an emerging trend to increase drug delivery to the brain. In order to overcome rapid nasal mucociliary clearance, low epithelial permeation, and local enzymatic degradation, we investigated the influence of PEGylation on nose-to-brain delivery of polycapr...

journal_title：Drug delivery and translational research

authors： de Oliveira Junior ER,Santos LCR,Salomão MA,Nascimento TL,de Almeida Ribeiro Oliveira G,Lião LM,Lima EM

更新日期：2020-12-01 00:00:00

abstract：:Drug nanocrystals have rapidly evolved into a mature drug delivery strategy in the last decade, with almost 16 products currently on the market. Several "top-down" technologies are available in the market for generation of nanocrystals. Despite several advantages, very few bottom-up technologies have been explored for...

journal_title：Drug delivery and translational research

authors： Shete G,Bansal AK

更新日期：2016-08-01 00:00:00

abstract：:The pretargeting approach using bispecific affibody-antibody complex (BAAC) and targeting of chemotherapeutic drug loaded polymers have been used in breast cancer cell cultures to demonstrate targeted chemotherapy and reduce toxicity to non-pretargeted cancer and cardiac cells. HER2/neu-positive BT-474 and -negative B...

journal_title：Drug delivery and translational research

authors： Gada KS,Patil V,Panwar R,Hatefi A,Khaw BA

更新日期：2012-02-01 00:00:00

abstract：:The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After per...

journal_title：Drug delivery and translational research

authors： Ma J,Gao Y,Sun Y,Ding D,Zhang Q,Sun B,Wang M,Sun J,He Z

更新日期：2017-10-01 00:00:00