Abstract：
:Nanotechnology is expected to revolutionize existing drug delivery. Many nanostructured systems have been employed for drug delivery and yielded some promising results. Solid lipid nanoparticles (SLN) have been looked at as a potential drug carrier system since last two decades. SLN do not show biotoxicity as they are prepared from physiological lipids. SLN are especially useful in drug delivery as they can enhance the absorption of drugs and improves the bioavailability of both hydrophilic and lipophilic drugs. This paper presents an overview about the various classes of SLN, comparison with available drug carrier systems, different ways of production, in vivo fate and biodistribution and various applications of SLN. Besides, aspects of stability, hurdles and strategies for SLN manufacturing with potential of clinical translation are also discussed.
journal_name
Drug Deliv Transl Resjournal_title
Drug delivery and translational researchauthors
Mishra DK,Dhote V,Bhatnagar P,Mishra PKdoi
10.1007/s13346-012-0088-9subject
Has Abstractpub_date
2012-08-01 00:00:00pages
238-53issue
4eissn
2190-393Xissn
2190-3948journal_volume
2pub_type
杂志文章abstract：:Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-017-0391-6
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abstract：:The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were e...
journal_title：Drug delivery and translational research
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journal_title：Drug delivery and translational research
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更新日期：2020-11-06 00:00:00
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journal_title：Drug delivery and translational research
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abstract：:Pulsed electric fields (PEFs) are applied as physical stimuli for DNA/drug delivery, cancer therapy, gene transformation, and microorganism eradication. Meanwhile, calcium electrotransfer offers an interesting approach to treat cancer, as it induces cell death easier in malignant cells than in normal cells. Here, we s...
journal_title：Drug delivery and translational research
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doi：10.1007/s13346-018-0533-5
更新日期：2018-10-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
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journal_title：Drug delivery and translational research
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更新日期：2015-12-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0480-1
更新日期：2019-04-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0158-7
更新日期：2014-02-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0415-2
更新日期：2017-10-01 00:00:00
abstract：:The efforts of the topical microbicide field to identify a safe and effective topical microbicide were realized in July of 2010 with the reporting of the results of the Centre for the AIDS Programme of Research in South Africa 004 trial. In this trial, a 1% tenofovir gel was found to reduce women's risk for HIV acquis...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-011-0034-2
更新日期：2011-06-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-019-00697-0
更新日期：2020-04-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0130-6
更新日期：2013-08-01 00:00:00
abstract：:This study evaluated effects of differing gel volumes on pharmacokinetics (PK). IQB4012, a gel containing the non-nucleoside reverse transcriptase inhibitor IQP-0528 and tenofovir (TFV), was applied to the pigtailed macaque vagina and rectum. Vaginal gel volumes (1% loading of both drugs) were 0.5 or 1.5 ml; following...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0538-0
更新日期：2018-10-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0178-3
更新日期：2013-12-01 00:00:00
abstract：:The bioadhesive hollow microspheres of riboflavin were developed as a site-specific gastroretentive system to prolong the residence time of drug in the stomach and, consequently, to enhance the bioavailability. Hollow microspheres (M1-M9) prepared by the emulsion solvent diffusion method using ethyl cellulose and Eudr...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0143-1
更新日期：2013-06-01 00:00:00
abstract：:In vivo toxicity and absorption studies of topical ocular drugs are problematic, because these studies involve invasive tissue sampling and toxic effects in animal models. Therefore, different human corneal models ranging from simple monolayer cultures to three-dimensional models have been developed for toxicological ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-016-0330-y
更新日期：2016-12-01 00:00:00
abstract：:The concept of guided bone regeneration facilitated by barrier membranes has been widely considered to achieve enhanced bone healing in maxillofacial surgery. However, the currently available membranes are limited in their active regulation of cellular activities. In this study, we fabricated polycaprolactone/gelatin ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0154-y
更新日期：2015-04-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0577-6
更新日期：2019-02-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00852-y
更新日期：2020-09-23 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00846-w
更新日期：2020-12-01 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章,评审
doi：10.1007/s13346-015-0266-7
更新日期：2016-04-01 00:00:00
abstract：:Gemcitabine is used as a first-line drug for treating many solid tumours. However, it suffers from a major drawback of strong side effects and short plasma half-life because of degradation by enzyme when administered intravenously. Polyesters and copolyesters are the most widely used and preferred class of biodegradab...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-017-0372-9
更新日期：2017-06-01 00:00:00
abstract：:The work describes systematic development of nanomicellar cationic supersaturable self-nanoemulsifying drug delivery systems (CS-SNEDDS) for augmenting oral biopharmaceutical performance of raloxifene hydrochloride. Plain SNEDDS formulation containing Capryol 90, Cremophor RH 40, and Transcutol HP was optimized using ...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0514-8
更新日期：2018-06-01 00:00:00
abstract：:The present work investigates the targeting efficacy of a novel thiolated polymer-based nanocomposite reinforced with glycyrrhetinic acid (GA) and loaded with 5-fluorouracil in hepatocellular carcinoma (HCC). The thiolated polymers were synthesized by EDAC-mediated conjugation reactions and lyophilization. The nanopar...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-020-00894-2
更新日期：2021-01-11 00:00:00
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journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0491-y
更新日期：2019-04-01 00:00:00
abstract：:High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsu...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-018-0521-9
更新日期：2018-12-01 00:00:00
abstract：:A novel approach to concurrently deliver oral and inhaled drugs as a single formulation is presented. A triple therapy containing theophylline (THEO; orally delivered) with budesonide (BUD) and terbutaline (TERB; as single and co-spray-dried inhaled powders) was prepared as an ordered mix, with THEO acting as a carrie...
journal_title：Drug delivery and translational research
pub_type： 杂志文章
doi：10.1007/s13346-013-0137-z
更新日期：2014-06-01 00:00:00
